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Protein

Transmembrane protein 35A

Gene

TMEM35A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35A
Gene namesi
Name:TMEM35AImported
Synonyms:TMEM35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25864. TMEM35A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126950.
PharmGKBiPA134905238.

Polymorphism and mutation databases

BioMutaiTMEM35.
DMDMi121957117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716071 – 167Transmembrane protein 35AAdd BLAST167

Proteomic databases

EPDiQ53FP2.
PaxDbiQ53FP2.
PeptideAtlasiQ53FP2.
PRIDEiQ53FP2.
TopDownProteomicsiQ53FP2.

PTM databases

iPTMnetiQ53FP2.
PhosphoSitePlusiQ53FP2.

Expressioni

Gene expression databases

BgeeiENSG00000126950.
CleanExiHS_TMEM35.
GenevisibleiQ53FP2. HS.

Organism-specific databases

HPAiHPA048583.

Interactioni

Subunit structurei

May interact with NGFR.By similarity

Protein-protein interaction databases

BioGridi121894. 1 interactor.
IntActiQ53FP2. 2 interactors.
STRINGi9606.ENSP00000362021.

Structurei

3D structure databases

ProteinModelPortaliQ53FP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 54Interaction with NGFRBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ53FP2.
OMAiVVWYQTS.
OrthoDBiEOG091G0TZU.
PhylomeDBiQ53FP2.
TreeFamiTF300206.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53FP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE
160
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,440
Last modified:January 9, 2007 - v2
Checksum:i062A6E7700DB33B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50A → T in BAD96960 (Ref. 2) Curated1
Sequence conflicti60N → S in BAD96960 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024146 mRNA. Translation: BAB14840.1.
AK223240 mRNA. Translation: BAD96960.1.
AL109952 Genomic DNA. Translation: CAI43000.1.
BC050273 mRNA. Translation: AAH50273.1.
BC078658 mRNA. Translation: AAH78658.1.
CCDSiCCDS14478.1.
RefSeqiNP_067650.1. NM_021637.2.
UniGeneiHs.45140.
Hs.714277.

Genome annotation databases

EnsembliENST00000372930; ENSP00000362021; ENSG00000126950.
GeneIDi59353.
KEGGihsa:59353.
UCSCiuc004egw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024146 mRNA. Translation: BAB14840.1.
AK223240 mRNA. Translation: BAD96960.1.
AL109952 Genomic DNA. Translation: CAI43000.1.
BC050273 mRNA. Translation: AAH50273.1.
BC078658 mRNA. Translation: AAH78658.1.
CCDSiCCDS14478.1.
RefSeqiNP_067650.1. NM_021637.2.
UniGeneiHs.45140.
Hs.714277.

3D structure databases

ProteinModelPortaliQ53FP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121894. 1 interactor.
IntActiQ53FP2. 2 interactors.
STRINGi9606.ENSP00000362021.

PTM databases

iPTMnetiQ53FP2.
PhosphoSitePlusiQ53FP2.

Polymorphism and mutation databases

BioMutaiTMEM35.
DMDMi121957117.

Proteomic databases

EPDiQ53FP2.
PaxDbiQ53FP2.
PeptideAtlasiQ53FP2.
PRIDEiQ53FP2.
TopDownProteomicsiQ53FP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372930; ENSP00000362021; ENSG00000126950.
GeneIDi59353.
KEGGihsa:59353.
UCSCiuc004egw.4. human.

Organism-specific databases

CTDi59353.
GeneCardsiTMEM35.
HGNCiHGNC:25864. TMEM35A.
HPAiHPA048583.
neXtProtiNX_Q53FP2.
OpenTargetsiENSG00000126950.
PharmGKBiPA134905238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ53FP2.
OMAiVVWYQTS.
OrthoDBiEOG091G0TZU.
PhylomeDBiQ53FP2.
TreeFamiTF300206.

Miscellaneous databases

GenomeRNAii59353.
PROiQ53FP2.

Gene expression databases

BgeeiENSG00000126950.
CleanExiHS_TMEM35.
GenevisibleiQ53FP2. HS.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM35A_HUMAN
AccessioniPrimary (citable) accession number: Q53FP2
Secondary accession number(s): Q9H7Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.