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Protein

Transmembrane protein 35

Gene

TMEM35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35
Gene namesi
Name:TMEM35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25864. TMEM35.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13218HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905238.

Polymorphism and mutation databases

BioMutaiTMEM35.
DMDMi121957117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Transmembrane protein 35PRO_0000271607Add
BLAST

Proteomic databases

EPDiQ53FP2.
PaxDbiQ53FP2.
PeptideAtlasiQ53FP2.
PRIDEiQ53FP2.
TopDownProteomicsiQ53FP2.

PTM databases

iPTMnetiQ53FP2.
PhosphoSiteiQ53FP2.

Expressioni

Gene expression databases

BgeeiQ53FP2.
CleanExiHS_TMEM35.
GenevisibleiQ53FP2. HS.

Organism-specific databases

HPAiHPA048583.

Interactioni

Subunit structurei

May interact with NGFR.By similarity

Protein-protein interaction databases

BioGridi121894. 1 interaction.
STRINGi9606.ENSP00000362021.

Structurei

3D structure databases

ProteinModelPortaliQ53FP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 5412Interaction with NGFRBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM35 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ53FP2.
OMAiVVWYQTS.
OrthoDBiEOG7V768Z.
PhylomeDBiQ53FP2.
TreeFamiTF300206.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53FP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE
160
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,440
Last modified:January 9, 2007 - v2
Checksum:i062A6E7700DB33B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501A → T in BAD96960 (Ref. 2) Curated
Sequence conflicti60 – 601N → S in BAD96960 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024146 mRNA. Translation: BAB14840.1.
AK223240 mRNA. Translation: BAD96960.1.
AL109952 Genomic DNA. Translation: CAI43000.1.
BC050273 mRNA. Translation: AAH50273.1.
BC078658 mRNA. Translation: AAH78658.1.
CCDSiCCDS14478.1.
RefSeqiNP_067650.1. NM_021637.2.
UniGeneiHs.45140.
Hs.714277.

Genome annotation databases

EnsembliENST00000372930; ENSP00000362021; ENSG00000126950.
GeneIDi59353.
KEGGihsa:59353.
UCSCiuc004egw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024146 mRNA. Translation: BAB14840.1.
AK223240 mRNA. Translation: BAD96960.1.
AL109952 Genomic DNA. Translation: CAI43000.1.
BC050273 mRNA. Translation: AAH50273.1.
BC078658 mRNA. Translation: AAH78658.1.
CCDSiCCDS14478.1.
RefSeqiNP_067650.1. NM_021637.2.
UniGeneiHs.45140.
Hs.714277.

3D structure databases

ProteinModelPortaliQ53FP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121894. 1 interaction.
STRINGi9606.ENSP00000362021.

PTM databases

iPTMnetiQ53FP2.
PhosphoSiteiQ53FP2.

Polymorphism and mutation databases

BioMutaiTMEM35.
DMDMi121957117.

Proteomic databases

EPDiQ53FP2.
PaxDbiQ53FP2.
PeptideAtlasiQ53FP2.
PRIDEiQ53FP2.
TopDownProteomicsiQ53FP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372930; ENSP00000362021; ENSG00000126950.
GeneIDi59353.
KEGGihsa:59353.
UCSCiuc004egw.4. human.

Organism-specific databases

CTDi59353.
GeneCardsiTMEM35.
HGNCiHGNC:25864. TMEM35.
HPAiHPA048583.
neXtProtiNX_Q53FP2.
PharmGKBiPA134905238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ53FP2.
OMAiVVWYQTS.
OrthoDBiEOG7V768Z.
PhylomeDBiQ53FP2.
TreeFamiTF300206.

Miscellaneous databases

GenomeRNAii59353.
PROiQ53FP2.

Gene expression databases

BgeeiQ53FP2.
CleanExiHS_TMEM35.
GenevisibleiQ53FP2. HS.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastric mucosa.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTMM35_HUMAN
AccessioniPrimary (citable) accession number: Q53FP2
Secondary accession number(s): Q9H7Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 6, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.