Q53FJ5 (Q53FJ5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Prosaposin (Variant Gaucher disease and variant metachromatic leukodystrophy) variant EMBL BAD97010.1
Organism	Homo sapiens (Human) EMBL BAD97010.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	524 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	sphingolipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD97010.1

Sequences

	Sequence		Length	Mass (Da)
	Q53FJ5 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 7034F0C71C2226BC	FASTA	524	58,141
	10 20 30 40 50 60 MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS 70 80 90 100 110 120 LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI 130 140 150 160 170 180 IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY 190 200 210 220 230 240 PQDGPRSKPQ PKDNGDVCQD CIRMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI 250 260 270 280 290 300 CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE 310 320 330 340 350 360 PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV 370 380 390 400 410 420 VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD 430 440 450 460 470 480 RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG 490 500 510 520 ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWN

References

[1]	"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides." Maruyama K., Sugano S. Gene 138:171-174(1994) [PubMed: 8125298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Synovial membrane EMBL BAD97010.1.
[2]	"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library." Suzuki Y., Yoshitomo K., Maruyama K., Suyama A., Sugano S. Gene 200:149-156(1997) [PubMed: 9373149] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Synovial membrane EMBL BAD97010.1.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Synovial membrane EMBL BAD97010.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK223290 mRNA. Translation: BAD97010.1.
IPI	IPI00219825.
UniGene	Hs.523004.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q53FJ5.
Proteomic databases
PRIDE	Q53FJ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002617.
Gene expression databases
ArrayExpress	Q53FJ5.
Family and domain databases
InterPro	IPR003119. SapA. IPR007856. SapB_1. IPR008138. SapB_2. IPR008373. Saposin. IPR011001. Saposin-like. IPR021165. Saposin_chordata. IPR008139. SaposinB. [Graphical view]
Gene3D	G3DSA:1.10.225.10. Saposin_like. 4 hits.
Pfam	PF02199. SapA. 2 hits. PF05184. SapB_1. 4 hits. PF03489. SapB_2. 4 hits. [Graphical view]
PIRSF	PIRSF002431. Saposin. 1 hit.
PRINTS	PR01797. SAPOSIN.
SMART	SM00162. SAPA. 2 hits. SM00741. SapB. 4 hits. [Graphical view]
SUPFAM	SSF47862. Saposin_like. 4 hits.
PROSITE	PS51110. SAP_A. 2 hits. PS50015. SAP_B. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q53FJ5_HUMAN

Accession

Primary (citable) accession number: Q53FJ5

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.