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Protein

Uncharacterized protein C4orf17

Gene

C4orf17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf17
Gene namesi
Name:C4orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25274. C4orf17.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913125.

Polymorphism and mutation databases

BioMutaiC4orf17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Uncharacterized protein C4orf17PRO_0000089433Add
BLAST

Proteomic databases

EPDiQ53FE4.
PaxDbiQ53FE4.
PRIDEiQ53FE4.

PTM databases

PhosphoSiteiQ53FE4.

Expressioni

Gene expression databases

BgeeiQ53FE4.
CleanExiHS_C4orf17.
ExpressionAtlasiQ53FE4. baseline and differential.
GenevisibleiQ53FE4. HS.

Organism-specific databases

HPAiHPA060374.
HPA060564.

Interactioni

Protein-protein interaction databases

BioGridi123892. 8 interactions.
IntActiQ53FE4. 8 interactions.
MINTiMINT-8417633.
STRINGi9606.ENSP00000322582.

Structurei

3D structure databases

ProteinModelPortaliQ53FE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IM1W. Eukaryota.
ENOG41118NS. LUCA.
GeneTreeiENSGT00510000048844.
HOGENOMiHOG000111463.
HOVERGENiHBG081061.
InParanoidiQ53FE4.
OMAiNNIPICT.
OrthoDBiEOG7FR7GV.
PhylomeDBiQ53FE4.
TreeFamiTF330946.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53FE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLNPPTSAL QIEGKGSHIM ARNVSCFLVR HTPHPRRVCH IKGLNNIPIC
60 70 80 90 100
TVNDDENAFG TLWGVGQSNY LEKNRIPFAN CSYPSSTAVQ ESPVRGMSPA
110 120 130 140 150
PNGAKVPPRP HSEPSRKIKE CFKTSSENPL VIKKEEIKAK RPPSPPKACS
160 170 180 190 200
TPGSCSSGMT STKNDVKANT ICIPNYLDQE IKILAKLCSI LHTDSLAEVL
210 220 230 240 250
QWLLHATSKE KEWVSALIHS ELAEINLLTH HRRNTSMEPA AETGKPPTVK
260 270 280 290 300
SPPTVKLPPN FTAKSKVLTR DTEGDQPTRV SSQGSEENKE VPKEAEHKPP
310 320 330 340 350
LLIRRNNMKI PVAEYFSKPN SPPRPNTQES GSAKPVSARS IQEYNLCPQR

ACYPSTHRR
Length:359
Mass (Da):39,644
Last modified:October 17, 2006 - v3
Checksum:iCA29C013A6D13273
GO
Isoform 2 (identifier: Q53FE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-186: ILAK → ATLL
     187-359: Missing.

Note: No experimental confirmation available.
Show »
Length:186
Mass (Da):20,261
Checksum:i77EDDBF8310CB2DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891K → R in CAG38573 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641G → E.3 Publications
Corresponds to variant rs13143848 [ dbSNP | Ensembl ].
VAR_028110
Natural varianti85 – 851S → P.3 Publications
Corresponds to variant rs13119384 [ dbSNP | Ensembl ].
VAR_028111
Natural varianti91 – 911E → K.3 Publications
Corresponds to variant rs17029087 [ dbSNP | Ensembl ].
VAR_028112

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei183 – 1864ILAK → ATLL in isoform 2. 1 PublicationVSP_056907
Alternative sequencei187 – 359173Missing in isoform 2. 1 PublicationVSP_056908Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136838 mRNA. Translation: CAB66772.1.
CR533542 mRNA. Translation: CAG38573.1.
AK093085 mRNA. Translation: BAC04048.1.
AK223345 mRNA. Translation: BAD97065.1.
AC083902 Genomic DNA. No translation available.
AP001960 Genomic DNA. No translation available.
BC069805 mRNA. Translation: AAH69805.1.
BC074759 mRNA. Translation: AAH74759.1.
CCDSiCCDS3649.1. [Q53FE4-1]
RefSeqiNP_115525.2. NM_032149.2. [Q53FE4-1]
UniGeneiHs.97501.

Genome annotation databases

EnsembliENST00000326581; ENSP00000322582; ENSG00000138813. [Q53FE4-1]
ENST00000477187; ENSP00000423411; ENSG00000138813. [Q53FE4-2]
GeneIDi84103.
KEGGihsa:84103.
UCSCiuc003huw.3. human. [Q53FE4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136838 mRNA. Translation: CAB66772.1.
CR533542 mRNA. Translation: CAG38573.1.
AK093085 mRNA. Translation: BAC04048.1.
AK223345 mRNA. Translation: BAD97065.1.
AC083902 Genomic DNA. No translation available.
AP001960 Genomic DNA. No translation available.
BC069805 mRNA. Translation: AAH69805.1.
BC074759 mRNA. Translation: AAH74759.1.
CCDSiCCDS3649.1. [Q53FE4-1]
RefSeqiNP_115525.2. NM_032149.2. [Q53FE4-1]
UniGeneiHs.97501.

3D structure databases

ProteinModelPortaliQ53FE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123892. 8 interactions.
IntActiQ53FE4. 8 interactions.
MINTiMINT-8417633.
STRINGi9606.ENSP00000322582.

PTM databases

PhosphoSiteiQ53FE4.

Polymorphism and mutation databases

BioMutaiC4orf17.

Proteomic databases

EPDiQ53FE4.
PaxDbiQ53FE4.
PRIDEiQ53FE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326581; ENSP00000322582; ENSG00000138813. [Q53FE4-1]
ENST00000477187; ENSP00000423411; ENSG00000138813. [Q53FE4-2]
GeneIDi84103.
KEGGihsa:84103.
UCSCiuc003huw.3. human. [Q53FE4-1]

Organism-specific databases

CTDi84103.
GeneCardsiC4orf17.
HGNCiHGNC:25274. C4orf17.
HPAiHPA060374.
HPA060564.
neXtProtiNX_Q53FE4.
PharmGKBiPA134913125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM1W. Eukaryota.
ENOG41118NS. LUCA.
GeneTreeiENSGT00510000048844.
HOGENOMiHOG000111463.
HOVERGENiHBG081061.
InParanoidiQ53FE4.
OMAiNNIPICT.
OrthoDBiEOG7FR7GV.
PhylomeDBiQ53FE4.
TreeFamiTF330946.

Miscellaneous databases

GenomeRNAii84103.
NextBioi73359.
PROiQ53FE4.

Gene expression databases

BgeeiQ53FE4.
CleanExiHS_C4orf17.
ExpressionAtlasiQ53FE4. baseline and differential.
GenevisibleiQ53FE4. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-64; PRO-85 AND LYS-91.
    Tissue: Testis.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-64; PRO-85 AND LYS-91.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-64; PRO-85 AND LYS-91.
    Tissue: Testis.

Entry informationi

Entry nameiCD017_HUMAN
AccessioniPrimary (citable) accession number: Q53FE4
Secondary accession number(s): Q6FI84
, Q6IS77, Q8NA78, Q9H0D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: March 16, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.