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Protein

Zinc finger C2HC domain-containing protein 1C

Gene

ZC2HC1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 411C2HC-typeAdd BLAST25

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C2HC domain-containing protein 1C
Gene namesi
Name:ZC2HC1C
Synonyms:C14orf140, FAM164C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119703.13.
HGNCiHGNC:20354. ZC2HC1C.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119703.
PharmGKBiPA162386996.

Polymorphism and mutation databases

BioMutaiZC2HC1C.
DMDMi387912891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899401 – 456Zinc finger C2HC domain-containing protein 1CAdd BLAST456

Proteomic databases

PaxDbiQ53FD0.
PeptideAtlasiQ53FD0.
PRIDEiQ53FD0.

PTM databases

iPTMnetiQ53FD0.
PhosphoSitePlusiQ53FD0.

Expressioni

Gene expression databases

BgeeiENSG00000119703.
CleanExiHS_FAM164C.
ExpressionAtlasiQ53FD0. baseline and differential.
GenevisibleiQ53FD0. HS.

Organism-specific databases

HPAiHPA050928.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122817. 23 interactors.
IntActiQ53FD0. 49 interactors.
STRINGi9606.ENSP00000435550.

Structurei

3D structure databases

ProteinModelPortaliQ53FD0.
SMRiQ53FD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili211 – 265Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the ZC2HC1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 411C2HC-typeAdd BLAST25

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3940. Eukaryota.
ENOG4111J7C. LUCA.
GeneTreeiENSGT00390000003459.
HOVERGENiHBG056970.
InParanoidiQ53FD0.
OMAiKRVGVDR.
OrthoDBiEOG091G0Y8K.
PhylomeDBiQ53FD0.
TreeFamiTF319585.

Family and domain databases

InterProiView protein in InterPro
IPR026104. ZNF_C2HC_dom_1C.
PANTHERiPTHR14649. PTHR14649. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53FD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLQRLASH LPVGVMLPHN TTEAPGPHSA KQDSYEQGDS SQQSLKGHLR
60 70 80 90 100
NNFQKQLLSN KELILDKVYT HPKWNTQTKA RSYSYPHCTG ISQQDPESDS
110 120 130 140 150
QGQGNGLFYS SGPQSWYPKA NNQDFIPFTK KRVGVDRAFP LKPMVHRKSC
160 170 180 190 200
STGEAGTDGD HNVYPRPPEP REFSSRNFGV RNQGNFSVVG TVLAATQAEK
210 220 230 240 250
AVANFDRTEW VQIRRLEAAG ESLEEEIRRK QILLRGKLKK TEEELRRIQT
260 270 280 290 300
QKEQAKENEN GELQKIILPR SRVKGNKSNT MYKPIFSPEF EFEEEFSRDR
310 320 330 340 350
REDETWGRSQ QNSGPFQFSD YRIQRLKRER LVASNNKIRD PVSEPSVEKF
360 370 380 390 400
SPPSETPVGA LQGSARNSSL SMAPDSSGSS GSIEEPQLGE CSHCGRKFLS
410 420 430 440 450
FRLERHSNIC SRMRGSKRKV FDSSRARAKG TELEQYLNWK GPASAKAEPP

QKSNWR
Length:456
Mass (Da):51,658
Last modified:May 16, 2012 - v3
Checksum:iF7BD49C093D2AC2B
GO
Isoform 2 (identifier: Q53FD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-456: Missing.

Show »
Length:275
Mass (Da):31,049
Checksum:iCCE2437D8E08F9DB
GO

Sequence cautioni

The sequence BAB15541 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72P → L in BAD97079 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043105276 – 456Missing in isoform 2. 3 PublicationsAdd BLAST181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026746 mRNA. Translation: BAB15541.1. Frameshift.
AK223359 mRNA. Translation: BAD97079.1.
AL049780 Genomic DNA. No translation available.
BC004259 mRNA. Translation: AAH04259.1.
CCDSiCCDS41972.1. [Q53FD0-1]
CCDS45138.1. [Q53FD0-2]
RefSeqiNP_001035895.1. NM_001042430.2. [Q53FD0-2]
NP_078919.2. NM_024643.3. [Q53FD0-1]
XP_005268119.1. XM_005268062.3. [Q53FD0-1]
XP_011535457.1. XM_011537155.2. [Q53FD0-1]
XP_011535458.1. XM_011537156.2. [Q53FD0-1]
XP_016877133.1. XM_017021644.1. [Q53FD0-2]
XP_016877134.1. XM_017021645.1. [Q53FD0-2]
UniGeneiHs.48642.

Genome annotation databases

EnsembliENST00000439583; ENSP00000390606; ENSG00000119703. [Q53FD0-2]
ENST00000524913; ENSP00000435550; ENSG00000119703. [Q53FD0-1]
GeneIDi79696.
KEGGihsa:79696.
UCSCiuc001xrh.5. human. [Q53FD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZC21C_HUMAN
AccessioniPrimary (citable) accession number: Q53FD0
Secondary accession number(s): E9PJQ0, Q9BTA8, Q9H5S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 16, 2012
Last modified: September 27, 2017
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families