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Protein

Zinc finger C2HC domain-containing protein 1C

Gene

ZC2HC1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 411C2HC-typeAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C2HC domain-containing protein 1C
Gene namesi
Name:ZC2HC1C
Synonyms:C14orf140, FAM164C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20354. ZC2HC1C.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119703.
PharmGKBiPA162386996.

Polymorphism and mutation databases

BioMutaiZC2HC1C.
DMDMi387912891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899401 – 456Zinc finger C2HC domain-containing protein 1CAdd BLAST456

Proteomic databases

PaxDbiQ53FD0.
PeptideAtlasiQ53FD0.
PRIDEiQ53FD0.

PTM databases

iPTMnetiQ53FD0.
PhosphoSitePlusiQ53FD0.

Expressioni

Gene expression databases

BgeeiENSG00000119703.
CleanExiHS_FAM164C.
ExpressionAtlasiQ53FD0. baseline and differential.
GenevisibleiQ53FD0. HS.

Organism-specific databases

HPAiHPA050928.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-740767,EBI-744695
CCDC136Q96JN2-23EBI-740767,EBI-10171416
EMILIN1Q9Y6C23EBI-740767,EBI-744586
FSD2A1L4K13EBI-740767,EBI-5661036
GFAPP141363EBI-740767,EBI-744302
HOOK2Q96ED93EBI-740767,EBI-743290
KRT15P190124EBI-740767,EBI-739566
KRT40Q6A1623EBI-740767,EBI-10171697
MID2Q9UJV3-23EBI-740767,EBI-10172526
MTUS2Q5JR594EBI-740767,EBI-742948
PNMA1Q8ND904EBI-740767,EBI-302345
RABGEF1Q9UJ413EBI-740767,EBI-913954
SFNP319473EBI-740767,EBI-476295
SPAG5Q96R063EBI-740767,EBI-413317
SPERTQ8NA613EBI-740767,EBI-741724
TFIP11Q9UBB93EBI-740767,EBI-1105213
TRAF1Q130773EBI-740767,EBI-359224
TRAF2Q129333EBI-740767,EBI-355744
TRIM23P364063EBI-740767,EBI-740098
TRIM27P143733EBI-740767,EBI-719493

Protein-protein interaction databases

BioGridi122817. 23 interactors.
IntActiQ53FD0. 24 interactors.
STRINGi9606.ENSP00000435550.

Structurei

3D structure databases

ProteinModelPortaliQ53FD0.
SMRiQ53FD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili211 – 265Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the ZC2HC1 family.Curated
Contains 1 C2HC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 411C2HC-typeAdd BLAST25

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3940. Eukaryota.
ENOG4111J7C. LUCA.
GeneTreeiENSGT00390000003459.
HOVERGENiHBG056970.
InParanoidiQ53FD0.
OMAiFIPFTKK.
OrthoDBiEOG091G0Y8K.
PhylomeDBiQ53FD0.
TreeFamiTF319585.

Family and domain databases

InterProiIPR026104. ZNF_C2HC_dom_1C.
[Graphical view]
PANTHERiPTHR14649. PTHR14649. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53FD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLQRLASH LPVGVMLPHN TTEAPGPHSA KQDSYEQGDS SQQSLKGHLR
60 70 80 90 100
NNFQKQLLSN KELILDKVYT HPKWNTQTKA RSYSYPHCTG ISQQDPESDS
110 120 130 140 150
QGQGNGLFYS SGPQSWYPKA NNQDFIPFTK KRVGVDRAFP LKPMVHRKSC
160 170 180 190 200
STGEAGTDGD HNVYPRPPEP REFSSRNFGV RNQGNFSVVG TVLAATQAEK
210 220 230 240 250
AVANFDRTEW VQIRRLEAAG ESLEEEIRRK QILLRGKLKK TEEELRRIQT
260 270 280 290 300
QKEQAKENEN GELQKIILPR SRVKGNKSNT MYKPIFSPEF EFEEEFSRDR
310 320 330 340 350
REDETWGRSQ QNSGPFQFSD YRIQRLKRER LVASNNKIRD PVSEPSVEKF
360 370 380 390 400
SPPSETPVGA LQGSARNSSL SMAPDSSGSS GSIEEPQLGE CSHCGRKFLS
410 420 430 440 450
FRLERHSNIC SRMRGSKRKV FDSSRARAKG TELEQYLNWK GPASAKAEPP

QKSNWR
Length:456
Mass (Da):51,658
Last modified:May 16, 2012 - v3
Checksum:iF7BD49C093D2AC2B
GO
Isoform 2 (identifier: Q53FD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-456: Missing.

Show »
Length:275
Mass (Da):31,049
Checksum:iCCE2437D8E08F9DB
GO

Sequence cautioni

The sequence BAB15541 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72P → L in BAD97079 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043105276 – 456Missing in isoform 2. 3 PublicationsAdd BLAST181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026746 mRNA. Translation: BAB15541.1. Frameshift.
AK223359 mRNA. Translation: BAD97079.1.
AL049780 Genomic DNA. No translation available.
BC004259 mRNA. Translation: AAH04259.1.
CCDSiCCDS41972.1. [Q53FD0-1]
CCDS45138.1. [Q53FD0-2]
RefSeqiNP_001035895.1. NM_001042430.2. [Q53FD0-2]
NP_078919.2. NM_024643.3. [Q53FD0-1]
XP_005268119.1. XM_005268062.3. [Q53FD0-1]
XP_011535457.1. XM_011537155.2. [Q53FD0-1]
XP_011535458.1. XM_011537156.2. [Q53FD0-1]
XP_016877133.1. XM_017021644.1. [Q53FD0-2]
XP_016877134.1. XM_017021645.1. [Q53FD0-2]
UniGeneiHs.48642.

Genome annotation databases

EnsembliENST00000439583; ENSP00000390606; ENSG00000119703. [Q53FD0-2]
ENST00000524913; ENSP00000435550; ENSG00000119703. [Q53FD0-1]
GeneIDi79696.
KEGGihsa:79696.
UCSCiuc001xrh.5. human. [Q53FD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026746 mRNA. Translation: BAB15541.1. Frameshift.
AK223359 mRNA. Translation: BAD97079.1.
AL049780 Genomic DNA. No translation available.
BC004259 mRNA. Translation: AAH04259.1.
CCDSiCCDS41972.1. [Q53FD0-1]
CCDS45138.1. [Q53FD0-2]
RefSeqiNP_001035895.1. NM_001042430.2. [Q53FD0-2]
NP_078919.2. NM_024643.3. [Q53FD0-1]
XP_005268119.1. XM_005268062.3. [Q53FD0-1]
XP_011535457.1. XM_011537155.2. [Q53FD0-1]
XP_011535458.1. XM_011537156.2. [Q53FD0-1]
XP_016877133.1. XM_017021644.1. [Q53FD0-2]
XP_016877134.1. XM_017021645.1. [Q53FD0-2]
UniGeneiHs.48642.

3D structure databases

ProteinModelPortaliQ53FD0.
SMRiQ53FD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122817. 23 interactors.
IntActiQ53FD0. 24 interactors.
STRINGi9606.ENSP00000435550.

PTM databases

iPTMnetiQ53FD0.
PhosphoSitePlusiQ53FD0.

Polymorphism and mutation databases

BioMutaiZC2HC1C.
DMDMi387912891.

Proteomic databases

PaxDbiQ53FD0.
PeptideAtlasiQ53FD0.
PRIDEiQ53FD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439583; ENSP00000390606; ENSG00000119703. [Q53FD0-2]
ENST00000524913; ENSP00000435550; ENSG00000119703. [Q53FD0-1]
GeneIDi79696.
KEGGihsa:79696.
UCSCiuc001xrh.5. human. [Q53FD0-1]

Organism-specific databases

CTDi79696.
GeneCardsiZC2HC1C.
HGNCiHGNC:20354. ZC2HC1C.
HPAiHPA050928.
neXtProtiNX_Q53FD0.
OpenTargetsiENSG00000119703.
PharmGKBiPA162386996.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3940. Eukaryota.
ENOG4111J7C. LUCA.
GeneTreeiENSGT00390000003459.
HOVERGENiHBG056970.
InParanoidiQ53FD0.
OMAiFIPFTKK.
OrthoDBiEOG091G0Y8K.
PhylomeDBiQ53FD0.
TreeFamiTF319585.

Miscellaneous databases

GenomeRNAii79696.
PROiQ53FD0.

Gene expression databases

BgeeiENSG00000119703.
CleanExiHS_FAM164C.
ExpressionAtlasiQ53FD0. baseline and differential.
GenevisibleiQ53FD0. HS.

Family and domain databases

InterProiIPR026104. ZNF_C2HC_dom_1C.
[Graphical view]
PANTHERiPTHR14649. PTHR14649. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZC21C_HUMAN
AccessioniPrimary (citable) accession number: Q53FD0
Secondary accession number(s): E9PJQ0, Q9BTA8, Q9H5S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 16, 2012
Last modified: November 2, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.