UniProtKB - Q53F39 (MPPE1_HUMAN)
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Protein
Metallophosphoesterase 1
Gene
MPPE1
Organism
Homo sapiens (Human)
Status
Functioni
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.1 Publication
Cofactori
Mn2+1 PublicationNote: Binds 2 manganese ions per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 77 | Divalent metal cation 2Curated | 1 | |
Metal bindingi | 119 | Divalent metal cation 1Curated | 1 | |
Metal bindingi | 119 | Divalent metal cation 2Curated | 1 | |
Metal bindingi | 157 | Divalent metal cation 1Curated | 1 | |
Metal bindingi | 249 | Divalent metal cation 1Curated | 1 | |
Metal bindingi | 303 | Divalent metal cation 1Curated | 1 | |
Metal bindingi | 305 | Divalent metal cation 2Curated | 1 |
GO - Molecular functioni
- GPI anchor binding Source: UniProtKB
- manganese ion binding Source: UniProtKB
- phosphoric diester hydrolase activity Source: UniProtKB
GO - Biological processi
- ER to Golgi vesicle-mediated transport Source: UniProtKB
- GPI anchor biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | ER-Golgi transport, GPI-anchor biosynthesis, Transport |
Ligand | Manganese, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Metallophosphoesterase 1 (EC:3.1.-.-)Alternative name(s): Post-GPI attachment to proteins factor 5 |
Gene namesi | Name:MPPE1 Synonyms:PGAP5 ORF Names:PP579 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000154889.16. |
HGNCi | HGNC:15988. MPPE1. |
MIMi | 611900. gene. |
neXtProti | NX_Q53F39. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 27 – 47 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 77 | D → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 79 | H → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 119 | D → A or N: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 157 | N → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 158 | H → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 249 | H → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 303 | H → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 305 | H → A: Affects transport of GPI-anchor proteins. 1 Publication | 1 | |
Mutagenesisi | 392 – 394 | KRK → ARA: Affects subcellular localization. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 65258. |
OpenTargetsi | ENSG00000154889. |
PharmGKBi | PA134913534. |
Polymorphism and mutation databases
BioMutai | MPPE1. |
DMDMi | 215274110. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315727 | 1 – 396 | Metallophosphoesterase 1Add BLAST | 396 |
Proteomic databases
MaxQBi | Q53F39. |
PaxDbi | Q53F39. |
PeptideAtlasi | Q53F39. |
PRIDEi | Q53F39. |
PTM databases
iPTMneti | Q53F39. |
PhosphoSitePlusi | Q53F39. |
Expressioni
Tissue specificityi
Expressed in brain.1 Publication
Gene expression databases
Bgeei | ENSG00000154889. |
ExpressionAtlasi | Q53F39. baseline and differential. |
Genevisiblei | Q53F39. HS. |
Organism-specific databases
HPAi | HPA012639. |
Interactioni
Subunit structurei
Interacts with GPI-anchor proteins. Interacts with TMED10.1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 122415. 79 interactors. |
IntActi | Q53F39. 2 interactors. |
STRINGi | 9606.ENSP00000465894. |
Structurei
3D structure databases
ProteinModelPortali | Q53F39. |
SMRi | Q53F39. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 392 – 396 | Di-lysine motif | 5 |
Domaini
The di-lysine motif (KxKxx) acts as an endoplasmic reticulum retrieval signal.1 Publication
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3662. Eukaryota. ENOG410ZM57. LUCA. |
GeneTreei | ENSGT00390000013236. |
HOVERGENi | HBG101555. |
InParanoidi | Q53F39. |
OMAi | QKLLWWL. |
OrthoDBi | EOG091G0LJF. |
PhylomeDBi | Q53F39. |
Family and domain databases
Gene3Di | 3.60.21.10. 1 hit. |
InterProi | View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR033308. PGAP5/Cdc1/Ted1. |
PANTHERi | PTHR13315. PTHR13315. 1 hit. |
Pfami | View protein in Pfam PF00149. Metallophos. 1 hit. |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q53F39-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAMIELGFGR QNFHPLKRKS SLLLKLIAVV FAVLLFCEFL IYYLAIFQCN
60 70 80 90 100
WPEVKTTASD GEQTTREPVL KAMFLADTHL LGEFLGHWLD KLRREWQMER
110 120 130 140 150
AFQTALWLLQ PEVVFILGDI FDEGKWSTPE AWADDVERFQ KMFRHPSHVQ
160 170 180 190 200
LKVVAGNHDI GFHYEMNTYK VERFEKVFSS ERLFSWKGIN FVMVNSVALN
210 220 230 240 250
GDGCGICSET EAELIEVSHR LNCSREARGS SRCGPGPLLP TSAPVLLQHY
260 270 280 290 300
PLYRRSDANC SGEDAAPAEE RDIPFKENYD VLSREASQKL LWWLQPRLVL
310 320 330 340 350
SGHTHSACEV HHGGRVPELS VPSFSWRNRN NPSFIMGSIT PTDYTLSKCY
360 370 380 390
LPREDVVLII YCGVVGFLVV LTLTHFGLLA SPFLSGLNLL GKRKTR
Sequence cautioni
The sequence BAB13863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | L → S in BAB14378 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 32 | A → T in BAB14378 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 97 | Q → R in AAL55744 (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 301 | S → I in AAH73994 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 364 | V → E in AAM00279 (PubMed:11978971).Curated | 1 | |
Sequence conflicti | 364 | V → E in AAM00277 (PubMed:11978971).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038294 | 138 | R → Q. Corresponds to variant dbSNP:rs11872520Ensembl. | 1 | |
Natural variantiVAR_038295 | 197 | V → M. Corresponds to variant dbSNP:rs35611363Ensembl. | 1 | |
Natural variantiVAR_038296 | 268 | A → P4 PublicationsCorresponds to variant dbSNP:rs662515Ensembl. | 1 | |
Natural variantiVAR_038297 | 336 | M → L. Corresponds to variant dbSNP:rs16976814Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030679 | 226 | E → EQ in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_030680 | 227 – 289 | Missing in isoform 4. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_030681 | 227 – 256 | ARGSS…LYRRS → VGEHLNATGAFCPVLLRFGC SLSPLALLAL in isoform 5. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_030682 | 257 – 396 | Missing in isoform 5. 1 PublicationAdd BLAST | 140 | |
Alternative sequenceiVSP_030683 | 338 – 396 | SITPT…KRKTR → TDA in isoform 2 and isoform 3. 4 PublicationsAdd BLAST | 59 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000309976; ENSP00000311200; ENSG00000154889. [Q53F39-4] ENST00000317235; ENSP00000327257; ENSG00000154889. [Q53F39-4] ENST00000496196; ENSP00000433950; ENSG00000154889. [Q53F39-2] ENST00000588072; ENSP00000465894; ENSG00000154889. [Q53F39-1] |
GeneIDi | 65258. |
KEGGi | hsa:65258. |
UCSCi | uc002kqf.5. human. [Q53F39-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MPPE1_HUMAN | |
Accessioni | Q53F39Primary (citable) accession number: Q53F39 Secondary accession number(s): B0YJ39 Q9HAI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | November 25, 2008 | |
Last modified: | March 28, 2018 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |