Q53EZ4 (CEP55_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Centrosomal protein of 55 kDa
Short name=Cep55

Alternative name(s):
Up-regulated in colon cancer 6

Gene names

Name:	CEP55
Synonyms:	C10orf3, URCC6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Ref.9 Ref.11
Subunit structure	Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28. Ref.1 Ref.9 Ref.11 Ref.12 Ref.17
Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole. Cytoplasm › cytoskeleton › centrosome. Cleavage furrow. Midbody. Note: Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. Ref.1 Ref.9 Ref.11 Ref.12
Tissue specificity	Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain. Ref.1 Ref.9
Post-translational modification	There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully. Ref.9
Sequence caution	The sequence BAA91670.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokinesis Inferred from genetic interaction PubMed 19638580. Source: MGI mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	centriole Inferred from electronic annotation. Source: UniProtKB-SubCell centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB cleavage furrow Inferred from electronic annotation. Source: UniProtKB-SubCell intercellular bridge Inferred from electronic annotation. Source: Compara midbody Inferred from direct assay PubMed 20186884. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53EZ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53EZ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     389-400: NQITQLESLKQL → KNNTVGILETAS
     401-464: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 464

464

Centrosomal protein of 55 kDa

PRO_0000089777

Regions

Region

157 – 236

80

Interaction with TSG101

Region

160 – 214

55

Interaction with PDCD6IP

Region

355 – 464

110

Required for localization to the interphase centrosome and to the midbody during cytokinesis

Coiled coil

22 – 186

165

Potential

Coiled coil

238 – 337

100

Potential

Coiled coil

374 – 403

30

Potential

Amino acid modifications

Modified residue

425

1

Phosphoserine; by CDK1 and MAPK1 Ref.9 Ref.10 Ref.13 Ref.14

Modified residue

428

1

Phosphoserine; by CDK1 and MAPK1 Ref.9 Ref.14

Modified residue

430

1

Phosphothreonine Ref.14

Modified residue

436

1

Phosphoserine; by PLK1 Ref.9 Ref.14

Natural variations

Alternative sequence

389 – 400

12

NQITQ…SLKQL → KNNTVGILETAS in isoform 2.

VSP_014750

Alternative sequence

401 – 464

64

Missing in isoform 2.

VSP_014751

Natural variant

57

1

H → Q. Ref.1 Ref.3
Corresponds to variant rs3740370 [ dbSNP | Ensembl ].

VAR_026559

Natural variant

99

1

T → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.7 Ref.8 Ref.18 Ref.19
Corresponds to variant rs7080916 [ dbSNP | Ensembl ].

VAR_022996

Natural variant

236

1

C → R.
Corresponds to variant rs7072484 [ dbSNP | Ensembl ].

VAR_056791

Natural variant

378

1

H → L. Ref.3 Ref.4 Ref.7 Ref.8
Corresponds to variant rs2293277 [ dbSNP | Ensembl ].

VAR_022997

Experimental info

Mutagenesis

184

1

W → A: Abolishes interaction with PDCD6IP. Ref.17

Mutagenesis

187

1

Y → A: Abolishes interaction with PDCD6IP. Ref.17

Mutagenesis

188

1

D → A: Diminishes interaction with PDCD6IP. Ref.17

Mutagenesis

191

1

R → A: Abolishes interaction with PDCD6IP. Ref.17

Mutagenesis

192

1

E → A: Abolishes interaction with PDCD6IP. Ref.17

Mutagenesis

396

1

S → A: No effect on phosphorylation in mitotic cells. Ref.9

Mutagenesis

425

1

S → A: Partial loss of phosphorylation in mitotic cells. Complete loss of phosphorylation in mitotic cells; when associated with A-428. Remains associated with the centrosome throughout mitosis; when associated with A-428. Arrests mitotic cells at the midbody stage; when associated with A-428 and A-436. Ref.9

Mutagenesis

428

1

S → A: Partial loss of phosphorylation in mitotic cells. Complete loss of phosphorylation in mitotic cells; when associated with A-425. Remains associated with the centrosome throughout mitosis; when associated with A-425. Arrests mitotic cells at the midbody stage; when associated with A-425 and A-436. Ref.9

Mutagenesis

436

1

S → A: No effect on phosphorylation in mitotic cells. Arrests mitotic cells at the midbody stage; when associated with A-425 and A-428. Ref.9

Sequence conflict

155

1

V → A in BAD97215. Ref.4

Sequence conflict

204

1

E → G in BAD97215. Ref.4

Sequence conflict

298

1

R → G in CAE45837. Ref.5

Sequence conflict

334

1

F → S in AAX14687. Ref.1

Sequence conflict

334

1

F → S in BAA91670. Ref.3

Sequence conflict

435

1

E → G in AAX14687. Ref.1

Secondary structure

1

.

.

.

464

Helix Strand Turn

Details...

Helix

166 – 209

44

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: A652F86EBCE46A51	FASTA	464	54,178
	10 20 30 40 50 60 MSSRSTKDLI KSKWGSKPSN SKSETTLEKL KGEIAHLKTS VDEITSGKGK LTDKERHRLL 70 80 90 100 110 120 EKIRVLEAEK EKNAYQLTEK DKEIQRLRDQ LKARYSTTTL LEQLEETTRE GERREQVLKA 130 140 150 160 170 180 LSEEKDVLKQ QLSAATSRIA ELESKTNTLR LSQTVAPNCF NSSINNIHEM EIQLKDALEK 190 200 210 220 230 240 NQQWLVYDQQ REVYVKGLLA KIFELEKKTE TAAHSLPQQT KKPESEGYLQ EEKQKCYNDL 250 260 270 280 290 300 LASAKKDLEV ERQTITQLSF ELSEFRRKYE ETQKEVHNLN QLLYSQRRAD VQHLEDDRHK 310 320 330 340 350 360 TEKIQKLREE NDIARGKLEE EKKRSEELLS QVQFLYTSLL KQQEEQTRVA LLEQQMQACT 370 380 390 400 410 420 LDFENEKLDR QHVQHQLHVI LKELRKARNQ ITQLESLKQL HEFAITEPLV TFQGETENRE 430 440 450 460 KVAASPKSPT AALNESLVEC PKCNIQYPAT EHRDLLVHVE YCSK
	Isoform 2 [UniParc]. Checksum: 61FCFE0A0965559F	FASTA	400	46,857
	10 20 30 40 50 60 MSSRSTKDLI KSKWGSKPSN SKSETTLEKL KGEIAHLKTS VDEITSGKGK LTDKERHRLL 70 80 90 100 110 120 EKIRVLEAEK EKNAYQLTEK DKEIQRLRDQ LKARYSTTTL LEQLEETTRE GERREQVLKA 130 140 150 160 170 180 LSEEKDVLKQ QLSAATSRIA ELESKTNTLR LSQTVAPNCF NSSINNIHEM EIQLKDALEK 190 200 210 220 230 240 NQQWLVYDQQ REVYVKGLLA KIFELEKKTE TAAHSLPQQT KKPESEGYLQ EEKQKCYNDL 250 260 270 280 290 300 LASAKKDLEV ERQTITQLSF ELSEFRRKYE ETQKEVHNLN QLLYSQRRAD VQHLEDDRHK 310 320 330 340 350 360 TEKIQKLREE NDIARGKLEE EKKRSEELLS QVQFLYTSLL KQQEEQTRVA LLEQQMQACT 370 380 390 400 LDFENEKLDR QHVQHQLHVI LKELRKARKN NTVGILETAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody." Martinez-Garay I., Rustom A., Gerdes H.-H., Kutsche K. Genomics 87:243-253(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, HOMODIMERIZATION, VARIANTS GLN-57 AND ALA-99.
[2]	"Cloning and characterization of URCC6, a novel gene up-regulated in colon cancer." Shimokawa T., Furukawa Y., Sakai M., Nakamura Y. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-99.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-464 (ISOFORM 2), VARIANTS GLN-57; ALA-99 AND LEU-378.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-99 AND LEU-378.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-99. Tissue: Esophageal carcinoma.
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ALA-99 AND LEU-378.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-99 AND LEU-378. Tissue: Muscle.
[9]	"Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis." Fabbro M., Zhou B.-B., Takahashi M., Sarcevic B., Lal P., Graham M.E., Gabrielli B.G., Robinson P.J., Nigg E.A., Ono Y., Khanna K.K. Dev. Cell 9:477-488(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH PLK1; AKAP9 AND PCNT, PHOSPHORYLATION AT SER-425; SER-428 AND SER-436, MUTAGENESIS OF SER-396; SER-425; SER-428 AND SER-436, MASS SPECTROMETRY.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis." Morita E., Sandrin V., Chung H.Y., Morham S.G., Gygi S.P., Rodesch C.K., Sundquist W.I. EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, SELF-ASSOCIATION, INTERACTION WITH PDCD6IP; TSG101; MVB12A; VPS37B; VPS37C AND VPS28.
[12]	"Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery." Carlton J.G., Martin-Serrano J. Science 316:1908-1912(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SELF-ASSOCIATION, INTERACTION WITH PDCD6IP AND TSG101, SUBCELLULAR LOCATION.
[13]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-428; THR-430 AND SER-436, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55." Lee H.H., Elia N., Ghirlando R., Lippincott-Schwartz J., Hurley J.H. Science 322:576-580(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 160-217 IN COMPLEX WITH PDCD6IP, INTERACTION WITH TSG101, MUTAGENESIS OF TRP-184; TYR-187; ASP-188; ARG-191 AND GLU-192.
[18]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-99, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[19]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-99, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY788918 mRNA. Translation: AAX14687.1.
AB091343 mRNA. Translation: BAE45243.1.
AK001402 mRNA. Translation: BAA91670.1. Different initiation.
AK315536 mRNA. Translation: BAG37915.1.
AK223495 mRNA. Translation: BAD97215.1.
BX640718 mRNA. Translation: CAE45837.1.
AL356214 Genomic DNA. Translation: CAH72324.1.
CH471066 Genomic DNA. Translation: EAW50071.1.
BC008947 mRNA. Translation: AAH08947.1.

IPI

IPI00101532.
IPI00478943.

RefSeq

NP_001120654.1. NM_001127182.1.
NP_060601.3. NM_018131.4.

UniGene

Hs.14559.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3E1R	X-ray	2.00	A/B	160-217	[»]

ProteinModelPortal

Q53EZ4.

SMR

Q53EZ4. Positions 165-210.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-44581N.

IntAct

Q53EZ4. 7 interactions.

MINT

MINT-4994059.

STRING

9606.ENSP00000360540.

PTM databases

PhosphoSite

Q53EZ4.

Polymorphism databases

DMDM

296439403.

Proteomic databases

PaxDb

Q53EZ4.

PRIDE

Q53EZ4.

Protocols and materials databases

DNASU

55165.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000371485; ENSP00000360540; ENSG00000138180.

GeneID

55165.

KEGG

hsa:55165.

UCSC

uc001kiq.4. human.

Organism-specific databases

CTD

55165.

GeneCards

GC10P095247.

HGNC

HGNC:1161. CEP55.

HPA

HPA023430.

MIM

610000. gene.

neXtProt

NX_Q53EZ4.

PharmGKB

PA25475.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG135886.

HOVERGEN

HBG081092.

InParanoid

Q53EZ4.

KO

K16456.

OMA

KQLHEFA.

OrthoDB

EOG4FN4JB.

PhylomeDB

Q53EZ4.

Gene expression databases

ArrayExpress

Q53EZ4.

Bgee

Q53EZ4.

CleanEx

HS_CEP55.

Genevestigator

Q53EZ4.

GermOnline

ENSG00000138180. Homo sapiens.

Family and domain databases

InterPro

IPR022008. EABR.
[Graphical view]

Pfam

PF12180. EABR. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q53EZ4.

GenomeRNAi

55165.

NextBio

58933.

SOURCE

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Entry information

Entry name

CEP55_HUMAN

Accession

Primary (citable) accession number: Q53EZ4
Secondary accession number(s): B2RDG8 , Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.