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Protein

V-type proton ATPase subunit a

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei401 – 42525HelicalUniRule annotationAdd
BLAST
Transmembranei445 – 46420HelicalUniRule annotationAdd
BLAST
Transmembranei541 – 56222HelicalUniRule annotationAdd
BLAST
Transmembranei568 – 59225HelicalUniRule annotationAdd
BLAST
Transmembranei633 – 65725HelicalUniRule annotationAdd
BLAST
Transmembranei735 – 75824HelicalUniRule annotationAdd
BLAST
Transmembranei764 – 78724HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25146.

PTM / Processingi

Proteomic databases

PaxDbiQ53ET5.
PeptideAtlasiQ53ET5.

Expressioni

Gene expression databases

GenevisibleiQ53ET5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000264649.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 12835Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
HOGENOMiHOG000037059.
HOVERGENiHBG014606.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q53ET5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPYVNVFQRK
60 70 80 90 100
FVNEVRRCEE MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN
110 120 130 140 150
FEKIENELKE INTNQEALKR NFLELTELKF ILRKTQQFFD EMADPDLLEE
160 170 180 190 200
SSSLLEPSEM GRGTPLRLGF VAGVINRERI PTFERMLWRV CRGNVFLRQA
210 220 230 240 250
EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF RASLYPCPET
260 270 280 290 300
PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
310 320 330 340 350
KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS
360 370 380 390 400
ILNRMQTNQT PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP
410 420 430 440 450
FLFAVMFGDF GHGILMTLFA VWMVLRESRI LSQKNENEMF STVFSGRYII
460 470 480 490 500
LLMGVFSMYT GLIYNDCFSK SLNIFGSSWS VRPMFTYNWT EETLRGNPVL
510 520 530 540 550
QLNPALPGVF GGPYPFGIDP IWNIATNKLT FLNSFKMKMS VILGIIHMLF
560 570 580 590 600
GVSLSLFNHI YFKKPLNIYF GFIPEIIFMT SLFGYLVILI FYKWTAYDAH
610 620 630 640 650
TSENAPSLLI HFINMFLFSY PESGYSMLYS GQKGIQCFLV VVALLCVPWM
660 670 680 690 700
LLFKPLVLRR QYLRRKHLGT LNFGGIRVGN GPTEEDAEII QHDQLSTHSE
710 720 730 740 750
DADEFDFGDT MVHQAIHTIE YCLGCISNTA SYLRLWALSL AHAQLSEVLW
760 770 780 790 800
TMVIHIGLSV KSLAGGLVLF FFFTAFATLT VAILLIMEGL SAFLHALRLH
810 820 830
WVEFQNKFYS GTGFKFLPFS FEHIREGKFE E
Length:831
Mass (Da):95,804
Last modified:May 24, 2005 - v1
Checksum:i0C84BE64B8CC0D03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223554 mRNA. Translation: BAD97274.1.
RefSeqiNP_001123492.1. NM_001130020.1.
UniGeneiHs.463074.

Genome annotation databases

GeneIDi535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223554 mRNA. Translation: BAD97274.1.
RefSeqiNP_001123492.1. NM_001130020.1.
UniGeneiHs.463074.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264649.

Proteomic databases

PaxDbiQ53ET5.
PeptideAtlasiQ53ET5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi535.

Organism-specific databases

CTDi535.
PharmGKBiPA25146.

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
HOGENOMiHOG000037059.
HOVERGENiHBG014606.

Miscellaneous databases

GenomeRNAii535.

Gene expression databases

GenevisibleiQ53ET5. HS.

Family and domain databases

InterProiIPR002490. V-ATPase_116kDa_su.
IPR026028. V-type_ATPase_116kDa_su_euka.
[Graphical view]
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiPF01496. V_ATPase_I. 1 hit.
[Graphical view]
PIRSFiPIRSF001293. ATP6V0A1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ53ET5_HUMAN
AccessioniPrimary (citable) accession number: Q53ET5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.