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Protein

Tigger transposable element-derived protein 5

Gene

TIGD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi74 – 94H-T-H motifBy similarityAdd BLAST21
DNA bindingi145 – 178H-T-H motifBy similarityAdd BLAST34

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 5
Gene namesi
Name:TIGD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18336. TIGD5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179886.
ENSG00000278016.

Polymorphism and mutation databases

BioMutaiTIGD5.
DMDMi384872678.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002726181 – 642Tigger transposable element-derived protein 5Add BLAST642

Proteomic databases

MaxQBiQ53EQ6.
PaxDbiQ53EQ6.
PeptideAtlasiQ53EQ6.
PRIDEiQ53EQ6.

PTM databases

iPTMnetiQ53EQ6.
PhosphoSitePlusiQ53EQ6.

Expressioni

Gene expression databases

BgeeiENSG00000179886.
CleanExiHS_TIGD5.
GenevisibleiQ53EQ6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA4Q1RN333EBI-10242213,EBI-10194128

Protein-protein interaction databases

BioGridi124381. 41 interactors.
IntActiQ53EQ6. 2 interactors.
STRINGi9606.ENSP00000421489.

Structurei

3D structure databases

ProteinModelPortaliQ53EQ6.
SMRiQ53EQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 98HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini112 – 185HTH CENPB-typePROSITE-ProRule annotationAdd BLAST74
Domaini233 – 357DDE-1 1Sequence analysisAdd BLAST125
Domaini410 – 477DDE-1 2Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 44Pro-richAdd BLAST42
Compositional biasi192 – 226Pro-richAdd BLAST35

Sequence similaritiesi

Contains 2 DDE-1 domains.Sequence analysis
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMJI. Eukaryota.
ENOG4111PP6. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000172539.
HOVERGENiHBG069618.
InParanoidiQ53EQ6.
OMAiWLENQDP.
OrthoDBiEOG091G05QK.
PhylomeDBiQ53EQ6.
TreeFamiTF338616.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 2 hits.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q53EQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYPAGPPAGP VPRRGRRPLP GPPAPAPAPV PAARPPPPAP GPRPRVAVKM
60 70 80 90 100
AFRKAYSIKD KLQAIERVKG GERQASVCRD FGVPGGTLRG WLKDEPKLRW
110 120 130 140 150
FLEQLGGEVG TQRKKMRLAN EEEIDRAVYA WFLALRQHGV PLSGPLIQAQ
160 170 180 190 200
AEAFARQIYG PECTFKASHG WFWRWQKRHG ISSQRFYGEA GPPAPSPAPG
210 220 230 240 250
PPVKEEPALP SGAGPLPDRA PAPPPPAEGG YGDEQIYSAS VTGLYWKLLP
260 270 280 290 300
EQAAPPGAGD PGAGGCGRRW RGDRVTVLLA ANLTGSHKLK PLVIGRLPDP
310 320 330 340 350
PSLRHHNQDK FPASYRYSPD AWLSRPLLRG WFFEEFVPGV KRYLRRSCLQ
360 370 380 390 400
QKAVLLVAHP PCPSPAASMP ALDSEDAPVR CRPEPLGPPE ELQTPDGAVR
410 420 430 440 450
VLFLSKGSSR AHIPAPLEQG VVAAFKQLYK RELLRLAVSC ASGSPLDFMR
460 470 480 490 500
SFMLKDMLYL AGLSWDLVQA GSIERCWLLG LRAAFEPRPG EDSAGQPAQA
510 520 530 540 550
EEAAEHSRVL SDLTHLAALA YKCLAPEEVA EWLHLDDDGG PPEGCREEVG
560 570 580 590 600
PALPPAAPPA PASLPSAMGG GEDEEEATDY GGTSVPTAGE AVRGLETALR
610 620 630 640
WLENQDPREV GPLRLVQLRS LISMARRLGG IGHTPAGPYD GV
Length:642
Mass (Da):69,222
Last modified:April 18, 2012 - v3
Checksum:iF805B9BA95C15CE3
GO
Isoform 2 (identifier: Q53EQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:593
Mass (Da):64,329
Checksum:i07DAF1E2471300CB
GO

Sequence cautioni

The sequence AAH32632 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55398 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD97303 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91W → C in BAD97303 (Ref. 3) Curated1
Sequence conflicti262G → R in AAH69229 (PubMed:15489334).Curated1
Sequence conflicti447D → G in BAB55398 (PubMed:14702039).Curated1
Sequence conflicti632G → W in AAH32632 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030043568M → I.3 PublicationsCorresponds to variant rs10282929dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427961 – 49Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
BC032632 mRNA. Translation: AAH32632.1. Different initiation.
BC069229 mRNA. Translation: AAH69229.1.
AK223583 mRNA. Translation: BAD97303.1. Different initiation.
AK027832 mRNA. Translation: BAB55398.1. Different initiation.
CCDSiCCDS6406.2. [Q53EQ6-1]
RefSeqiNP_116251.4. NM_032862.4. [Q53EQ6-1]
UniGeneiHs.71574.

Genome annotation databases

EnsembliENST00000321385; ENSP00000315906; ENSG00000278016. [Q53EQ6-1]
ENST00000504548; ENSP00000421489; ENSG00000179886. [Q53EQ6-1]
GeneIDi84948.
KEGGihsa:84948.
UCSCiuc003yyx.3. human. [Q53EQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
BC032632 mRNA. Translation: AAH32632.1. Different initiation.
BC069229 mRNA. Translation: AAH69229.1.
AK223583 mRNA. Translation: BAD97303.1. Different initiation.
AK027832 mRNA. Translation: BAB55398.1. Different initiation.
CCDSiCCDS6406.2. [Q53EQ6-1]
RefSeqiNP_116251.4. NM_032862.4. [Q53EQ6-1]
UniGeneiHs.71574.

3D structure databases

ProteinModelPortaliQ53EQ6.
SMRiQ53EQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124381. 41 interactors.
IntActiQ53EQ6. 2 interactors.
STRINGi9606.ENSP00000421489.

PTM databases

iPTMnetiQ53EQ6.
PhosphoSitePlusiQ53EQ6.

Polymorphism and mutation databases

BioMutaiTIGD5.
DMDMi384872678.

Proteomic databases

MaxQBiQ53EQ6.
PaxDbiQ53EQ6.
PeptideAtlasiQ53EQ6.
PRIDEiQ53EQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321385; ENSP00000315906; ENSG00000278016. [Q53EQ6-1]
ENST00000504548; ENSP00000421489; ENSG00000179886. [Q53EQ6-1]
GeneIDi84948.
KEGGihsa:84948.
UCSCiuc003yyx.3. human. [Q53EQ6-1]

Organism-specific databases

CTDi84948.
GeneCardsiTIGD5.
HGNCiHGNC:18336. TIGD5.
neXtProtiNX_Q53EQ6.
OpenTargetsiENSG00000179886.
ENSG00000278016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMJI. Eukaryota.
ENOG4111PP6. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000172539.
HOVERGENiHBG069618.
InParanoidiQ53EQ6.
OMAiWLENQDP.
OrthoDBiEOG091G05QK.
PhylomeDBiQ53EQ6.
TreeFamiTF338616.

Miscellaneous databases

ChiTaRSiTIGD5. human.
GenomeRNAii84948.
PROiQ53EQ6.

Gene expression databases

BgeeiENSG00000179886.
CleanExiHS_TIGD5.
GenevisibleiQ53EQ6. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 2 hits.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIGD5_HUMAN
AccessioniPrimary (citable) accession number: Q53EQ6
Secondary accession number(s): E7EWS2
, Q6NT83, Q8N5A1, Q96JW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: April 18, 2012
Last modified: November 30, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.