Q53EL9 (SEZ6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Seizure protein 6 homolog
Short name=SEZ-6
Short name=hSEZ-6

Gene names

Name:

SEZ6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	994 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Note: Localized on dendrites and in the synaptic and postsynaptic fraction By similarity.
Post-translational modification	Glycosylated By similarity. Ref.6
Sequence similarities	Belongs to the SEZ6 family. Contains 2 CUB domains. Contains 5 Sushi (CCP/SCR) domains.
Sequence caution	The sequence AAK71497.1 differs from that shown. Reason: Frameshift at positions 902 and 911. The sequence AAM22213.1 differs from that shown. Reason: Frameshift at positions 902 and 911. The sequence BAB70826.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB70912.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Sushi Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of dendrite development Inferred from electronic annotation. Source: Compara positive regulation of dendrite development Inferred from electronic annotation. Source: Compara regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara
Cellular_component	dendritic shaft Inferred from electronic annotation. Source: Compara dendritic spine Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q53EL9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q53EL9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q53EL9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     985-994: SLSFAGDERI → ETREYEVSI

Note: No experimental confirmation available.

Isoform 4 (identifier: Q53EL9-4)

Also known as: SEZ6b;

The sequence of this isoform differs from the canonical sequence as follows:
     493-508: LPIEGLLSSGKHFFVE → PPPPPPLQPHYHRVSV
     509-994: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 994	975	Seizure protein 6 homolog		PRO_0000341346
Regions
	Topological domain	20 – 925	906	Extracellular Potential
	Transmembrane	926 – 946	21	Helical; Potential
	Topological domain	947 – 994	48	Cytoplasmic Potential
	Domain	355 – 414	60	Sushi 1
	Domain	416 – 527	112	CUB 1
	Domain	530 – 591	62	Sushi 2
	Domain	593 – 704	112	CUB 2
	Domain	708 – 767	60	Sushi 3
	Domain	769 – 832	64	Sushi 4
	Domain	836 – 897	62	Sushi 5
	Region	38 – 47	10	O-glycosylated at two sites
	Region	59 – 63	5	O-glycosylated at two sites
	Compositional bias	90 – 188	99	Pro-rich
	Compositional bias	211 – 240	30	Thr-rich
Amino acid modifications
	Glycosylation	289	1	N-linked (GlcNAc...) Potential
	Glycosylation	399	1	N-linked (GlcNAc...) Potential
	Glycosylation	436	1	N-linked (GlcNAc...) Potential
	Glycosylation	541	1	N-linked (GlcNAc...) Potential
	Disulfide bond	357 ↔ 397		By similarity
	Disulfide bond	383 ↔ 412		By similarity
	Disulfide bond	416 ↔ 443		By similarity
	Disulfide bond	532 ↔ 574		By similarity
	Disulfide bond	559 ↔ 589		By similarity
	Disulfide bond	593 ↔ 619		By similarity
	Disulfide bond	710 ↔ 752		By similarity
	Disulfide bond	738 ↔ 765		By similarity
	Disulfide bond	771 ↔ 813		By similarity
	Disulfide bond	799 ↔ 830		By similarity
	Disulfide bond	838 ↔ 880		By similarity
	Disulfide bond	866 ↔ 895		By similarity
Natural variations
	Alternative sequence	1 – 125	125	Missing in isoform 2.		VSP_034250
	Alternative sequence	493 – 508	16	LPIEG…HFFVE → PPPPPPLQPHYHRVSV in isoform 4.		VSP_034251
	Alternative sequence	509 – 994	486	Missing in isoform 4.		VSP_034252
	Alternative sequence	985 – 994	10	SLSFAGDERI → ETREYEVSI in isoform 3.		VSP_034253
	Natural variant	300	1	V → M. Ref.7		VAR_044048
	Natural variant	330	1	A → V. Ref.7		VAR_044049
	Natural variant	546	1	T → A. Corresponds to variant rs1976165 [ dbSNP | Ensembl ].		VAR_044050
	Natural variant	592	1	V → A. Ref.7		VAR_044051
	Natural variant	736	1	Y → N. Ref.7		VAR_044052
	Natural variant	756	1	L → V. Ref.7		VAR_044053
	Natural variant	806	1	M → T. Ref.2 Corresponds to variant rs12941884 [ dbSNP | Ensembl ].		VAR_044054
Experimental info
	Sequence conflict	78	1	Q → H in AAM22213. Ref.1
	Sequence conflict	78	1	Q → H in AAM22214. Ref.1
	Sequence conflict	78	1	Q → H in AAK71497. Ref.1
	Sequence conflict	93	1	P → S in AAM22213. Ref.1
	Sequence conflict	93	1	P → S in AAM22214. Ref.1
	Sequence conflict	93	1	P → S in AAK71497. Ref.1
	Sequence conflict	141	1	S → SPD in AAM22213. Ref.1
	Sequence conflict	141	1	S → SPD in AAM22214. Ref.1
	Sequence conflict	141	1	S → SPD in AAK71497. Ref.1
	Sequence conflict	288	1	Q → K in AAM22213. Ref.1
	Sequence conflict	288	1	Q → K in AAK71497. Ref.1
	Sequence conflict	359	1	F → L in BAD97340. Ref.3
	Sequence conflict	414 – 417	4	AACG → GECP in AAM22213. Ref.1
	Sequence conflict	414 – 417	4	AACG → GECP in AAK71497. Ref.1
	Sequence conflict	417	1	G → P in AAM22213. Ref.1
	Sequence conflict	417	1	G → P in AAK71497. Ref.1
	Sequence conflict	815	1	D → G in BAB70912. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: BF715A8EEA4101C6	FASTA	994	107,425
	10 20 30 40 50 60 MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ PERGVHFVTT 70 80 90 100 110 120 APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA PFTPSPLPRL ANQDSRPVFT 130 140 150 160 170 180 SPTPAMAAVP TQPQSKEGPW SPESESPMLR ITAPLPPGPS MAVPTLGPGE IASTTPPSRA 190 200 210 220 230 240 WTPTQEGPGD MGRPWVAEVV SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT 250 260 270 280 290 300 PGPCSWNFSG PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV 310 320 330 340 350 360 EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP 370 380 390 400 410 420 RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA TQPFWDSKEP VCIAACGGVI 430 440 450 460 470 480 RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE 490 500 510 520 530 540 APPVYDSYEV EYLPIEGLLS SGKHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG 550 560 570 580 590 600 NFSSSTPTYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS 610 620 630 640 650 660 AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDIRVLRI GPGDVLTFYD GDDLTARVLG 670 680 690 700 710 720 QYSGPRSHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW 730 740 750 760 770 780 KSPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLTWSE DLPSCQRVTS CHDPGDVEHS 790 800 810 820 830 840 RRLISSPKFP VGATVQYICD QGFVLMGSSI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG 850 860 870 880 890 900 LSAPENGARS PEKQLHPAGA TIHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAASL 910 920 930 940 950 960 DGFYNSRSLD VAKAPAASST LDAAHIAAAI FLPLVAMVLL VGGVYFYFSR LQGKSSLQLP 970 980 990 RPRPRPYNRI TIESAFDNPT YETGSLSFAG DERI
	Isoform 2 [UniParc]. Checksum: DECE12B2D89E9AEA	FASTA	869	94,072
	10 20 30 40 50 60 MAAVPTQPQS KEGPWSPESE SPMLRITAPL PPGPSMAVPT LGPGEIASTT PPSRAWTPTQ 70 80 90 100 110 120 EGPGDMGRPW VAEVVSQGAG IGIQGTITSS TASGDDEETT TTTTIITTTI TTVQTPGPCS 130 140 150 160 170 180 WNFSGPEGSL DSPTDLSSPT DVGLDCFFYI SVYPGYGVEI KVQNISLREG ETVTVEGLGG 190 200 210 220 230 240 PDPLPLANQS FLLRGQVIRS PTHQAALRFQ SLPPPAGPGT FHFHYQAYLL SCHFPRRPAY 250 260 270 280 290 300 GDVTVTSLHP GGSARFHCAT GYQLKGARHL TCLNATQPFW DSKEPVCIAA CGGVIRNATT 310 320 330 340 350 360 GRIVSPGFPG NYSNNLTCHW LLEAPEGQRL HLHFEKVSLA EDDDRLIIRN GDNVEAPPVY 370 380 390 400 410 420 DSYEVEYLPI EGLLSSGKHF FVELSTDSSG AAAGMALRYE AFQQGHCYEP FVKYGNFSSS 430 440 450 460 470 480 TPTYPVGTTV EFSCDPGYTL EQGSIIIECV DPHDPQWNET EPACRAVCSG EITDSAGVVL 490 500 510 520 530 540 SPNWPEPYGR GQDCIWGVHV EEDKRIMLDI RVLRIGPGDV LTFYDGDDLT ARVLGQYSGP 550 560 570 580 590 600 RSHFKLFTSM ADVTIQFQSD PGTSVLGYQQ GFVIHFFEVP RNDTCPELPE IPNGWKSPSQ 610 620 630 640 650 660 PELVHGTVVT YQCYPGYQVV GSSVLMCQWD LTWSEDLPSC QRVTSCHDPG DVEHSRRLIS 670 680 690 700 710 720 SPKFPVGATV QYICDQGFVL MGSSILTCHD RQAGSPKWSD RAPKCLLEQL KPCHGLSAPE 730 740 750 760 770 780 NGARSPEKQL HPAGATIHFS CAPGYVLKGQ ASIKCVPGHP SHWSDPPPIC RAASLDGFYN 790 800 810 820 830 840 SRSLDVAKAP AASSTLDAAH IAAAIFLPLV AMVLLVGGVY FYFSRLQGKS SLQLPRPRPR 850 860 PYNRITIESA FDNPTYETGS LSFAGDERI
	Isoform 3 [UniParc]. Checksum: EEDA368937831723	FASTA	993	107,456
	10 20 30 40 50 60 MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ PERGVHFVTT 70 80 90 100 110 120 APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA PFTPSPLPRL ANQDSRPVFT 130 140 150 160 170 180 SPTPAMAAVP TQPQSKEGPW SPESESPMLR ITAPLPPGPS MAVPTLGPGE IASTTPPSRA 190 200 210 220 230 240 WTPTQEGPGD MGRPWVAEVV SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT 250 260 270 280 290 300 PGPCSWNFSG PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV 310 320 330 340 350 360 EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP 370 380 390 400 410 420 RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA TQPFWDSKEP VCIAACGGVI 430 440 450 460 470 480 RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE 490 500 510 520 530 540 APPVYDSYEV EYLPIEGLLS SGKHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG 550 560 570 580 590 600 NFSSSTPTYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS 610 620 630 640 650 660 AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDIRVLRI GPGDVLTFYD GDDLTARVLG 670 680 690 700 710 720 QYSGPRSHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW 730 740 750 760 770 780 KSPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLTWSE DLPSCQRVTS CHDPGDVEHS 790 800 810 820 830 840 RRLISSPKFP VGATVQYICD QGFVLMGSSI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG 850 860 870 880 890 900 LSAPENGARS PEKQLHPAGA TIHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAASL 910 920 930 940 950 960 DGFYNSRSLD VAKAPAASST LDAAHIAAAI FLPLVAMVLL VGGVYFYFSR LQGKSSLQLP 970 980 990 RPRPRPYNRI TIESAFDNPT YETGETREYE VSI
	Isoform 4 (SEZ6b) [UniParc]. Checksum: C409C72F89CC7073	FASTA	508	54,396
	10 20 30 40 50 60 MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ PERGVHFVTT 70 80 90 100 110 120 APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA PFTPSPLPRL ANQDSRPVFT 130 140 150 160 170 180 SPTPAMAAVP TQPQSKEGPW SPESESPMLR ITAPLPPGPS MAVPTLGPGE IASTTPPSRA 190 200 210 220 230 240 WTPTQEGPGD MGRPWVAEVV SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT 250 260 270 280 290 300 PGPCSWNFSG PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV 310 320 330 340 350 360 EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCHFP 370 380 390 400 410 420 RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA TQPFWDSKEP VCIAACGGVI 430 440 450 460 470 480 RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE 490 500 APPVYDSYEV EYPPPPPPLQ PHYHRVSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Huang X.H., Guo J.H., Yu L. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain and Oligodendroglioma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-806. Tissue: Brain and Cerebellum.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-994 (ISOFORM 3). Tissue: Brain.
[6]	"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins." Halim A., Ruetschi U., Larson G., Nilsson J. J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION, MASS SPECTROMETRY.
[7]	"Febrile seizures are associated with mutation of seizure-related (SEZ) 6, a brain-specific gene." Yu Z.-L., Jiang J.-M., Wu D.-H., Xie H.-J., Jiang J.-J., Zhou L., Peng L., Bao G.-S. J. Neurosci. Res. 85:166-172(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MET-300; VAL-330; ALA-592; ASN-736 AND VAL-756.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY038048 mRNA. Translation: AAK71497.1. Frameshift. AF502129 mRNA. Translation: AAM22213.1. Frameshift. AF502130 mRNA. Translation: AAM22214.1. AK054913 mRNA. Translation: BAB70826.1. Different initiation. AK055383 mRNA. Translation: BAB70912.1. Different initiation. AK091522 mRNA. Translation: BAC03684.1. AK223620 mRNA. Translation: BAD97340.1. AC024267 Genomic DNA. No translation available. AC024619 Genomic DNA. No translation available. AL834405 mRNA. Translation: CAD39067.1.
IPI	IPI00154734. IPI00748395. IPI00895805. IPI00895924.
RefSeq	NP_001092105.1. NM_001098635.1. NP_849191.3. NM_178860.4.
UniGene	Hs.21837.
3D structure databases
HSSP	HSSP built from PDB template 1NT0 based on UniProtKB Q9QX89.
ProteinModelPortal	Q53EL9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q53EL9. 1 interaction.
MINT	MINT-1424044.
PTM databases
PhosphoSite	Q53EL9.
Polymorphism databases
DMDM	190410975.
Proteomic databases
PaxDb	Q53EL9.
PRIDE	Q53EL9.
Protocols and materials databases
DNASU	124925.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317338; ENSP00000312942; ENSG00000063015. ENST00000360295; ENSP00000353440; ENSG00000063015.
GeneID	124925.
KEGG	hsa:124925.
UCSC	uc002hdp.2. human. uc010cry.1. human.
Organism-specific databases
CTD	124925.
GeneCards	GC17M027281.
H-InvDB	HIX0013668.
HGNC	HGNC:15955. SEZ6.
HPA	HPA007703. HPA011777.
neXtProt	NX_Q53EL9.
PharmGKB	PA38065.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271485.
HOVERGEN	HBG057885.
InParanoid	Q53EL9.
OMA	SHFKLFT.
Gene expression databases
ArrayExpress	Q53EL9.
Bgee	Q53EL9.
CleanEx	HS_SEZ6.
Genevestigator	Q53EL9.
Family and domain databases
Gene3D	2.60.120.290. 3 hits.
InterPro	IPR000859. CUB_dom. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00431. CUB. 2 hits. PF00084. Sushi. 5 hits. [Graphical view]
SMART	SM00032. CCP. 5 hits. SM00042. CUB. 2 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 5 hits. SSF49854. CUB. 3 hits.
PROSITE	PS01180. CUB. 2 hits. PS50923. SUSHI. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	124925.
NextBio	81423.

Entry information

Entry name

SEZ6_HUMAN

Accession

Primary (citable) accession number: Q53EL9
Secondary accession number(s): B6ZDN1 , Q8N701, Q8NB57, Q8ND50, Q8TD25, Q96NI5, Q96NQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.