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Protein

Cytochrome c oxidase subunit 6B1

Gene

COX6B1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
Gene namesi
Name:COX6B1
Synonyms:COX6B
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Cytochrome c oxidase subunit 6B1PRO_0000194914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 66By similarity
Disulfide bondi41 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ53CG4.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000022035.

Structurei

3D structure databases

ProteinModelPortaliQ53CG4.
SMRiQ53CG4. Positions 9-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ53CG4.
KOiK02267.
OMAiLDFHRCQ.
OrthoDBiEOG7WDN54.
TreeFamiTF105065.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53CG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEDIETKI KNYKTAPFDS RFPNQNQTRN CWQNYLDFHR CQKAMTTKGG
60 70 80
NVSVCEWYQR VYQSLCPTSW VTDWDEQRAE GTFPGKI
Length:87
Mass (Da):10,318
Last modified:January 23, 2007 - v3
Checksum:iE9D30F7CA2230396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY585854 mRNA. Translation: AAW03183.1.
RefSeqiNP_001035371.1. NM_001040281.1.
XP_014979051.1. XM_015123565.1.
UniGeneiMmu.1407.

Genome annotation databases

EnsembliENSMMUT00000023552; ENSMMUP00000022035; ENSMMUG00000016765.
GeneIDi692062.
KEGGimcc:692062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY585854 mRNA. Translation: AAW03183.1.
RefSeqiNP_001035371.1. NM_001040281.1.
XP_014979051.1. XM_015123565.1.
UniGeneiMmu.1407.

3D structure databases

ProteinModelPortaliQ53CG4.
SMRiQ53CG4. Positions 9-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000022035.

Proteomic databases

PRIDEiQ53CG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000023552; ENSMMUP00000022035; ENSMMUG00000016765.
GeneIDi692062.
KEGGimcc:692062.

Organism-specific databases

CTDi1340.

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiQ53CG4.
KOiK02267.
OMAiLDFHRCQ.
OrthoDBiEOG7WDN54.
TreeFamiTF105065.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Rapid electrostatic evolution at the binding site for cytochrome c on cytochrome c oxidase in anthropoid primates."
    Schmidt T.R., Wildman D.E., Uddin M., Opazo J.C., Goodman M., Grossman L.I.
    Proc. Natl. Acad. Sci. U.S.A. 102:6379-6384(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCX6B1_MACMU
AccessioniPrimary (citable) accession number: Q53CG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.