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Q53B90 (RAB43_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ras-related protein Rab-43
Gene names
Name:Rab43
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium.

Subcellular location

Cytoplasmic vesicle › phagosome By similarity. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Golgi apparatus By similarity. Golgi apparatus › trans-Golgi network membrane; Lipid-anchor By similarity. Golgi apparatus › trans-Golgi network By similarity. Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Ras-related protein Rab-43
PRO_0000244617

Regions

Nucleotide binding23 – 308GTP By similarity
Nucleotide binding71 – 755GTP By similarity
Nucleotide binding129 – 1324GTP By similarity
Nucleotide binding161 – 1622GTP By similarity
Motif45 – 539Effector region By similarity

Amino acid modifications

Modified residue801Phosphothreonine By similarity
Modified residue2101Cysteine methyl ester By similarity
Lipidation2081S-geranylgeranyl cysteine By similarity
Lipidation2101S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q53B90 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 4D7DF08F84AE47A0

FASTA21023,229
        10         20         30         40         50         60 
MAGPGPGDQD EHYDFLFKLV LVGDASVGKT CVVQRFKTGA FSARQGSTIG VDFTMKTLEI 

        70         80         90        100        110        120 
QGKRVKLQIW DTAGQERFRT ITQSYYRSAN GAILAYDISK RSTFLSVPHW IEDVRKYAGS 

       130        140        150        160        170        180 
NIVQLLIGNK SDLADLREVP LAEAQSLAEH YDILCAIETS AKDSSNVEEA FTRVATELIM 

       190        200        210 
RHGGPMFSEK NTDHIQLDSK DIAESWGCGC

« Hide

References

[1]"Cloning, expression pattern and homology modeling of novel rat RAB genes."
Zhong C., Zhou G., Ji G., Yu L.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY593256 mRNA. Translation: AAT86135.1.
IPIIPI00204737.
RefSeqNP_001019502.1. NM_001024331.1.
UniGeneRn.141443.

3D structure databases

ProteinModelPortalQ53B90.
SMRQ53B90. Positions 13-184.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013299.

Proteomic databases

PaxDbQ53B90.
PRIDEQ53B90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013299; ENSRNOP00000013299; ENSRNOG00000037768.
GeneID500249.
KEGGrno:500249.
UCSCRGD:1565300. rat.

Organism-specific databases

CTD339122.
RGD1565300. Rab43.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00700000104044.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ53B90.
KOK07930.
OMALIGDCGT.
OrthoDBEOG4WQ13N.

Gene expression databases

GenevestigatorQ53B90.
GermOnlineENSRNOG00000037768. Rattus norvegicus.

Family and domain databases

InterProIPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio705573.

Entry information

Entry nameRAB43_RAT
AccessionPrimary (citable) accession number: Q53B90
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 24, 2005
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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