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Q53B90

- RAB43_RAT

UniProt

Q53B90 - RAB43_RAT

Protein

Ras-related protein Rab-43

Gene

Rab43

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 308GTPBy similarity
    Nucleotide bindingi71 – 755GTPBy similarity
    Nucleotide bindingi129 – 1324GTPBy similarity
    Nucleotide bindingi161 – 1622GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. Golgi organization Source: UniProtKB
    2. phagosome maturation Source: UniProtKB
    3. protein transport Source: InterPro
    4. retrograde transport, plasma membrane to Golgi Source: UniProtKB
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-43
    Gene namesi
    Name:Rab43
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1565300. Rab43.

    Subcellular locationi

    Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Golgi apparatus By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Lipid-anchor By similarity. Golgi apparatustrans-Golgi network By similarity
    Note: Recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. phagocytic vesicle Source: UniProtKB
    3. phagocytic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Ras-related protein Rab-43PRO_0000244617Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471PhosphoserineBy similarity
    Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity
    Modified residuei210 – 2101Cysteine methyl esterBy similarity
    Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ53B90.
    PRIDEiQ53B90.

    Expressioni

    Gene expression databases

    GenevestigatoriQ53B90.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013299.

    Structurei

    3D structure databases

    ProteinModelPortaliQ53B90.
    SMRiQ53B90. Positions 13-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 539Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00710000106357.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ53B90.
    KOiK07930.
    OMAiKTCIVQR.
    OrthoDBiEOG7NGQCK.
    PhylomeDBiQ53B90.
    TreeFamiTF300097.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q53B90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPGPGDQD EHYDFLFKLV LVGDASVGKT CVVQRFKTGA FSARQGSTIG    50
    VDFTMKTLEI QGKRVKLQIW DTAGQERFRT ITQSYYRSAN GAILAYDISK 100
    RSTFLSVPHW IEDVRKYAGS NIVQLLIGNK SDLADLREVP LAEAQSLAEH 150
    YDILCAIETS AKDSSNVEEA FTRVATELIM RHGGPMFSEK NTDHIQLDSK 200
    DIAESWGCGC 210
    Length:210
    Mass (Da):23,229
    Last modified:May 24, 2005 - v1
    Checksum:i4D7DF08F84AE47A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY593256 mRNA. Translation: AAT86135.1.
    RefSeqiNP_001019502.1. NM_001024331.1.
    UniGeneiRn.141443.

    Genome annotation databases

    EnsembliENSRNOT00000013299; ENSRNOP00000013299; ENSRNOG00000037768.
    GeneIDi500249.
    KEGGirno:500249.
    UCSCiRGD:1565300. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY593256 mRNA. Translation: AAT86135.1 .
    RefSeqi NP_001019502.1. NM_001024331.1.
    UniGenei Rn.141443.

    3D structure databases

    ProteinModelPortali Q53B90.
    SMRi Q53B90. Positions 13-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013299.

    Proteomic databases

    PaxDbi Q53B90.
    PRIDEi Q53B90.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013299 ; ENSRNOP00000013299 ; ENSRNOG00000037768 .
    GeneIDi 500249.
    KEGGi rno:500249.
    UCSCi RGD:1565300. rat.

    Organism-specific databases

    CTDi 339122.
    RGDi 1565300. Rab43.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00710000106357.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q53B90.
    KOi K07930.
    OMAi KTCIVQR.
    OrthoDBi EOG7NGQCK.
    PhylomeDBi Q53B90.
    TreeFami TF300097.

    Miscellaneous databases

    NextBioi 705573.
    PROi Q53B90.

    Gene expression databases

    Genevestigatori Q53B90.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression pattern and homology modeling of novel rat RAB genes."
      Zhong C., Zhou G., Ji G., Yu L.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiRAB43_RAT
    AccessioniPrimary (citable) accession number: Q53B90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3