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Protein

Ras-related protein Rab-43

Gene

Rab43

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTPBy similarity
Nucleotide bindingi71 – 755GTPBy similarity
Nucleotide bindingi129 – 1324GTPBy similarity
Nucleotide bindingi161 – 1622GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-43
Gene namesi
Name:Rab43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1565300. Rab43.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Ras-related protein Rab-43PRO_0000244617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471PhosphoserineBy similarity
Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity
Modified residuei210 – 2101Cysteine methyl esterBy similarity
Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ53B90.
PRIDEiQ53B90.

Expressioni

Gene expression databases

GenevisibleiQ53B90. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013299.

Structurei

3D structure databases

ProteinModelPortaliQ53B90.
SMRiQ53B90. Positions 13-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 539Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ53B90.
KOiK07930.
OMAiYRSANGI.
OrthoDBiEOG7NGQCK.
PhylomeDBiQ53B90.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53B90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPGPGDQD EHYDFLFKLV LVGDASVGKT CVVQRFKTGA FSARQGSTIG
60 70 80 90 100
VDFTMKTLEI QGKRVKLQIW DTAGQERFRT ITQSYYRSAN GAILAYDISK
110 120 130 140 150
RSTFLSVPHW IEDVRKYAGS NIVQLLIGNK SDLADLREVP LAEAQSLAEH
160 170 180 190 200
YDILCAIETS AKDSSNVEEA FTRVATELIM RHGGPMFSEK NTDHIQLDSK
210
DIAESWGCGC
Length:210
Mass (Da):23,229
Last modified:May 24, 2005 - v1
Checksum:i4D7DF08F84AE47A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY593256 mRNA. Translation: AAT86135.1.
RefSeqiNP_001019502.1. NM_001024331.1.
UniGeneiRn.141443.

Genome annotation databases

EnsembliENSRNOT00000013299; ENSRNOP00000013299; ENSRNOG00000037768.
GeneIDi500249.
KEGGirno:500249.
UCSCiRGD:1565300. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY593256 mRNA. Translation: AAT86135.1.
RefSeqiNP_001019502.1. NM_001024331.1.
UniGeneiRn.141443.

3D structure databases

ProteinModelPortaliQ53B90.
SMRiQ53B90. Positions 13-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013299.

Proteomic databases

PaxDbiQ53B90.
PRIDEiQ53B90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013299; ENSRNOP00000013299; ENSRNOG00000037768.
GeneIDi500249.
KEGGirno:500249.
UCSCiRGD:1565300. rat.

Organism-specific databases

CTDi339122.
RGDi1565300. Rab43.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ53B90.
KOiK07930.
OMAiYRSANGI.
OrthoDBiEOG7NGQCK.
PhylomeDBiQ53B90.
TreeFamiTF300097.

Miscellaneous databases

NextBioi705573.
PROiQ53B90.

Gene expression databases

GenevisibleiQ53B90. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression pattern and homology modeling of novel rat RAB genes."
    Zhong C., Zhou G., Ji G., Yu L.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiRAB43_RAT
AccessioniPrimary (citable) accession number: Q53B90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.