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Q53B90

- RAB43_RAT

UniProt

Q53B90 - RAB43_RAT

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Protein

Ras-related protein Rab-43

Gene
Rab43
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTP By similarity
Nucleotide bindingi71 – 755GTP By similarity
Nucleotide bindingi129 – 1324GTP By similarity
Nucleotide bindingi161 – 1622GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. Golgi organization Source: UniProtKB
  2. phagosome maturation Source: UniProtKB
  3. protein transport Source: InterPro
  4. retrograde transport, plasma membrane to Golgi Source: UniProtKB
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-43
Gene namesi
Name:Rab43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1565300. Rab43.

Subcellular locationi

Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Golgi apparatus By similarity. Golgi apparatustrans-Golgi network membrane; Lipid-anchor By similarity. Golgi apparatustrans-Golgi network By similarity
Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. phagocytic vesicle Source: UniProtKB
  3. phagocytic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Ras-related protein Rab-43PRO_0000244617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471Phosphoserine By similarity
Lipidationi208 – 2081S-geranylgeranyl cysteine By similarity
Modified residuei210 – 2101Cysteine methyl ester By similarity
Lipidationi210 – 2101S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ53B90.
PRIDEiQ53B90.

Expressioni

Gene expression databases

GenevestigatoriQ53B90.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013299.

Structurei

3D structure databases

ProteinModelPortaliQ53B90.
SMRiQ53B90. Positions 13-184.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 539Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00710000106357.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ53B90.
KOiK07930.
OMAiKTCIVQR.
OrthoDBiEOG7NGQCK.
PhylomeDBiQ53B90.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53B90-1 [UniParc]FASTAAdd to Basket

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MAGPGPGDQD EHYDFLFKLV LVGDASVGKT CVVQRFKTGA FSARQGSTIG    50
VDFTMKTLEI QGKRVKLQIW DTAGQERFRT ITQSYYRSAN GAILAYDISK 100
RSTFLSVPHW IEDVRKYAGS NIVQLLIGNK SDLADLREVP LAEAQSLAEH 150
YDILCAIETS AKDSSNVEEA FTRVATELIM RHGGPMFSEK NTDHIQLDSK 200
DIAESWGCGC 210
Length:210
Mass (Da):23,229
Last modified:May 24, 2005 - v1
Checksum:i4D7DF08F84AE47A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY593256 mRNA. Translation: AAT86135.1.
RefSeqiNP_001019502.1. NM_001024331.1.
UniGeneiRn.141443.

Genome annotation databases

EnsembliENSRNOT00000013299; ENSRNOP00000013299; ENSRNOG00000037768.
GeneIDi500249.
KEGGirno:500249.
UCSCiRGD:1565300. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY593256 mRNA. Translation: AAT86135.1 .
RefSeqi NP_001019502.1. NM_001024331.1.
UniGenei Rn.141443.

3D structure databases

ProteinModelPortali Q53B90.
SMRi Q53B90. Positions 13-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013299.

Proteomic databases

PaxDbi Q53B90.
PRIDEi Q53B90.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013299 ; ENSRNOP00000013299 ; ENSRNOG00000037768 .
GeneIDi 500249.
KEGGi rno:500249.
UCSCi RGD:1565300. rat.

Organism-specific databases

CTDi 339122.
RGDi 1565300. Rab43.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00710000106357.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q53B90.
KOi K07930.
OMAi KTCIVQR.
OrthoDBi EOG7NGQCK.
PhylomeDBi Q53B90.
TreeFami TF300097.

Miscellaneous databases

NextBioi 705573.
PROi Q53B90.

Gene expression databases

Genevestigatori Q53B90.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression pattern and homology modeling of novel rat RAB genes."
    Zhong C., Zhou G., Ji G., Yu L.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiRAB43_RAT
AccessioniPrimary (citable) accession number: Q53B90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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