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Protein

Transmembrane and ubiquitin-like domain-containing protein 1

Gene

Tmub1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (PubMed:18665261). Acts as negative regulator of hepatocyte growth during regeneration (PubMed:22426572).By similarity2 Publications
iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and ubiquitin-like domain-containing protein 1
Alternative name(s):
Hepatocyte odd protein shuttling protein
Cleaved into the following chain:
iHOPS1 Publication
Gene namesi
Name:Tmub1
Synonyms:Hops
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi735120 Tmub1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000435490? – 245iHOPS
ChainiPRO_00003702511 – 245Transmembrane and ubiquitin-like domain-containing protein 1Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1

Post-translational modificationi

iHOPS: Processed by regulated intramembrane proteolysis (RIP) in the N-terminus to release iHOPS from membranes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ53AQ4

PTM databases

iPTMnetiQ53AQ4
PhosphoSitePlusiQ53AQ4

Expressioni

Inductioni

Up-regulated in regenerating liver.1 Publication

Gene expression databases

BgeeiENSRNOG00000013383
GenevisibleiQ53AQ4 RN

Interactioni

Subunit structurei

Interacts with EEF1A1, GRIA2, GRIP1 (By similarity). Interacts with CAMLG, TUBG1. Interacts with NPM1 and CDKN2A; TMUB1 can enhance interaction between NPM1 and CDKN2A and is proposed to bridge the proteins; proposed to be mediated by iHOPS (PubMed:18418082, PubMed:22426572, PubMed:22890319). Interacts with ERLIN2 and AMFR; TMUB1 promotes the interaction of ERLIN2 with AMFR (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi263349, 2 interactors
IntActiQ53AQ4, 2 interactors
STRINGi10116.ENSRNOP00000058703

Structurei

3D structure databases

ProteinModelPortaliQ53AQ4
SMRiQ53AQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 175Ubiquitin-likePROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 30Required to release iHOPS from membranesBy similarityAdd BLAST29

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG1T Eukaryota
ENOG4111WH7 LUCA
GeneTreeiENSGT00390000014069
HOGENOMiHOG000232067
InParanoidiQ53AQ4
OMAiCVLHCHI
OrthoDBiEOG091G0NYR
PhylomeDBiQ53AQ4
TreeFamiTF329265

Family and domain databases

InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53AQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIEGVGDE VTVLFSVLAC LLVLALAWVS THTTESTDPL PQSSGTTTPA
60 70 80 90 100
QPSEAMTAID SIREEAPGAE SPSLRHRGPS AQPEPEAGVT ASTPPDSPQE
110 120 130 140 150
PLLLRLKFLN DSEQVARAWP QDTIGSLKRT QFPGREQQVR LIYQGQLLGD
160 170 180 190 200
DTQTLGSLHL PPNCVLHCHV STRVGPPHPP CPPGSEPGPS GLEIGSLLLP
210 220 230 240
LLLLLLLLLW YCQIQYRPFF PLTATLGLAG FTLLLSLLAF AMYRP
Length:245
Mass (Da):26,349
Last modified:May 24, 2005 - v1
Checksum:iA83B3C4AB6C992A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603378 mRNA Translation: AAU00154.1
CH474020 Genomic DNA Translation: EDL99355.1
RefSeqiNP_001073622.1, NM_001080153.2
NP_942076.2, NM_198781.3
XP_006236007.1, XM_006235945.3
UniGeneiRn.105624

Genome annotation databases

EnsembliENSRNOT00000061992; ENSRNOP00000058703; ENSRNOG00000013383
ENSRNOT00000088357; ENSRNOP00000074242; ENSRNOG00000013383
GeneIDi362301
KEGGirno:362301

Similar proteinsi

Entry informationi

Entry nameiTMUB1_RAT
AccessioniPrimary (citable) accession number: Q53AQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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