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Q539E5

- APX1_HYDVD

UniProt

Q539E5 - APX1_HYDVD

Protein

Putative ascorbate peroxidase

Gene

APX1

Organism
Hydra viridissima (Green hydra) (Chlorohydra viridissima)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    May play a role in the protection of oocyte incorporated cells from rapid apoptotic degradation.

    Catalytic activityi

    2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O.

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei54 – 541Transition state stabilizerPROSITE-ProRule annotation
    Active sitei58 – 581Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. L-ascorbate peroxidase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Protein family/group databases

    PeroxiBasei2285. HviNAnPrx01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ascorbate peroxidase (EC:1.11.1.11)
    Alternative name(s):
    HvAPX1
    Gene namesi
    Name:APX1
    OrganismiHydra viridissima (Green hydra) (Chlorohydra viridissima)
    Taxonomic identifieri6082 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 367351Putative ascorbate peroxidasePRO_0000023637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi60 ↔ 66PROSITE-ProRule annotation
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Developmental stagei

    Expressed exclusively during oogenesis.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ539E5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxidase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR010255. Haem_peroxidase.
    IPR002016. Haem_peroxidase_pln/fun/bac.
    IPR019793. Peroxidases_heam-ligand_BS.
    [Graphical view]
    PfamiPF00141. peroxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00458. PEROXIDASE.
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS00435. PEROXIDASE_1. 1 hit.
    PS50873. PEROXIDASE_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q539E5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPVIWLTVL IVLVDSLQII PTFHDFQRAK TDLLGLIESV KRGDDLPMIA    50
    GTVRLAFHDC IGKGKCDGCI DHSKPGNAGL KRVTDRLDAL YDASYKGKIS 100
    RADFYALASV TALTRSTANL SDKYNGLRKF KVGRKDCSTS PVESIDSSDI 150
    PRGSDGTSKT LQFFKSEFGM KTQEAVALLG AHTLGRCSLQ NSGFVGSWVD 200
    QRFSTAPPGE ENLSPTSILD NAYYRMIIDI VPWTQVNING TRIQWQEPSN 250
    SIPNDKLPES KRSPLLLNSD MAISWIIKPS DALGTVSCRP TSLKTPCRHS 300
    NAHTFAKIYA KNNALWVKDF TKAFNKMIEM NENKLRKAPI FNGYFDEMNS 350
    HDEPINESVD EISEDIF 367
    Length:367
    Mass (Da):40,790
    Last modified:May 24, 2005 - v1
    Checksum:i91E0A494F416A10D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY608909 mRNA. Translation: AAU07981.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY608909 mRNA. Translation: AAU07981.1 .

    3D structure databases

    ProteinModelPortali Q539E5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    PeroxiBasei 2285. HviNAnPrx01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR010255. Haem_peroxidase.
    IPR002016. Haem_peroxidase_pln/fun/bac.
    IPR019793. Peroxidases_heam-ligand_BS.
    [Graphical view ]
    Pfami PF00141. peroxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00458. PEROXIDASE.
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS00435. PEROXIDASE_1. 1 hit.
    PS50873. PEROXIDASE_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Symbiotic Hydra express a plant-like peroxidase gene during oogenesis."
      Habetha M., Bosch T.C.G.
      J. Exp. Biol. 208:2157-2165(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Strain: A99.

    Entry informationi

    Entry nameiAPX1_HYDVD
    AccessioniPrimary (citable) accession number: Q539E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The gene for this protein may have been transferred horizontally following an endosymbiotic event early in evolution of the Hydra lineage as an RNA or cDNA intermediate.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3