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Q539E5

- APX1_HYDVD

UniProt

Q539E5 - APX1_HYDVD

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Protein
Putative ascorbate peroxidase
Gene
APX1
Organism
Hydra viridissima (Green hydra) (Chlorohydra viridissima)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the protection of oocyte incorporated cells from rapid apoptotic degradation.

Catalytic activityi

2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei54 – 541Transition state stabilizer By similarity
Active sitei58 – 581Proton acceptor By similarity

GO - Molecular functioni

  1. L-ascorbate peroxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2285. HviNAnPrx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ascorbate peroxidase (EC:1.11.1.11)
Alternative name(s):
HvAPX1
Gene namesi
Name:APX1
OrganismiHydra viridissima (Green hydra) (Chlorohydra viridissima)
Taxonomic identifieri6082 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 367351Putative ascorbate peroxidase
PRO_0000023637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 66 By similarity
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed exclusively during oogenesis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ539E5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q539E5-1 [UniParc]FASTAAdd to Basket

« Hide

MVPVIWLTVL IVLVDSLQII PTFHDFQRAK TDLLGLIESV KRGDDLPMIA    50
GTVRLAFHDC IGKGKCDGCI DHSKPGNAGL KRVTDRLDAL YDASYKGKIS 100
RADFYALASV TALTRSTANL SDKYNGLRKF KVGRKDCSTS PVESIDSSDI 150
PRGSDGTSKT LQFFKSEFGM KTQEAVALLG AHTLGRCSLQ NSGFVGSWVD 200
QRFSTAPPGE ENLSPTSILD NAYYRMIIDI VPWTQVNING TRIQWQEPSN 250
SIPNDKLPES KRSPLLLNSD MAISWIIKPS DALGTVSCRP TSLKTPCRHS 300
NAHTFAKIYA KNNALWVKDF TKAFNKMIEM NENKLRKAPI FNGYFDEMNS 350
HDEPINESVD EISEDIF 367
Length:367
Mass (Da):40,790
Last modified:May 24, 2005 - v1
Checksum:i91E0A494F416A10D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY608909 mRNA. Translation: AAU07981.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY608909 mRNA. Translation: AAU07981.1 .

3D structure databases

ProteinModelPortali Q539E5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

PeroxiBasei 2285. HviNAnPrx01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view ]
Pfami PF00141. peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00458. PEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS00435. PEROXIDASE_1. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Symbiotic Hydra express a plant-like peroxidase gene during oogenesis."
    Habetha M., Bosch T.C.G.
    J. Exp. Biol. 208:2157-2165(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: A99.

Entry informationi

Entry nameiAPX1_HYDVD
AccessioniPrimary (citable) accession number: Q539E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 24, 2005
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The gene for this protein may have been transferred horizontally following an endosymbiotic event early in evolution of the Hydra lineage as an RNA or cDNA intermediate.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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