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Protein

Putative ascorbate peroxidase

Gene

APX1

Organism
Hydra viridissima (Green hydra) (Chlorohydra viridissima)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the protection of oocyte incorporated cells from rapid apoptotic degradation.

Miscellaneous

The gene for this protein may have been transferred horizontally following an endosymbiotic event early in evolution of the Hydra lineage as an RNA or cDNA intermediate.

Catalytic activityi

2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O.

Cofactori

heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei54Transition state stabilizerPROSITE-ProRule annotation1
Active sitei58Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2285. HviNAnPrx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ascorbate peroxidase (EC:1.11.1.11)
Alternative name(s):
HvAPX1
Gene namesi
Name:APX1
OrganismiHydra viridissima (Green hydra) (Chlorohydra viridissima)
Taxonomic identifieri6082 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002363717 – 367Putative ascorbate peroxidaseAdd BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 66PROSITE-ProRule annotation
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed exclusively during oogenesis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ539E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019793. Peroxidases_heam-ligand_BS.
PfamiView protein in Pfam
PF00141. peroxidase. 1 hit.
PRINTSiPR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiView protein in PROSITE
PS00435. PEROXIDASE_1. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q539E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVIWLTVL IVLVDSLQII PTFHDFQRAK TDLLGLIESV KRGDDLPMIA
60 70 80 90 100
GTVRLAFHDC IGKGKCDGCI DHSKPGNAGL KRVTDRLDAL YDASYKGKIS
110 120 130 140 150
RADFYALASV TALTRSTANL SDKYNGLRKF KVGRKDCSTS PVESIDSSDI
160 170 180 190 200
PRGSDGTSKT LQFFKSEFGM KTQEAVALLG AHTLGRCSLQ NSGFVGSWVD
210 220 230 240 250
QRFSTAPPGE ENLSPTSILD NAYYRMIIDI VPWTQVNING TRIQWQEPSN
260 270 280 290 300
SIPNDKLPES KRSPLLLNSD MAISWIIKPS DALGTVSCRP TSLKTPCRHS
310 320 330 340 350
NAHTFAKIYA KNNALWVKDF TKAFNKMIEM NENKLRKAPI FNGYFDEMNS
360
HDEPINESVD EISEDIF
Length:367
Mass (Da):40,790
Last modified:May 24, 2005 - v1
Checksum:i91E0A494F416A10D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY608909 mRNA. Translation: AAU07981.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPX1_HYDVD
AccessioniPrimary (citable) accession number: Q539E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 24, 2005
Last modified: May 10, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families