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Protein

Leucine zipper protein 6

Gene

LUZP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper protein 6
Alternative name(s):
Myeloproliferative disease-associated 6 kDa antigen
Gene namesi
Name:LUZP6
Synonyms:MPD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33955. LUZP6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Leucine zipper protein 6PRO_0000318578Add
BLAST

Proteomic databases

PaxDbiQ538Z0.

PTM databases

iPTMnetiQ538Z0.
PhosphoSiteiQ538Z0.

Expressioni

Tissue specificityi

Widely expressed, highest levels found in brain, placenta, spleen, testis, and ovary. Up-regulated in some tumor cells.1 Publication

Inductioni

By IFNA1.1 Publication

Gene expression databases

GenevisibleiQ538Z0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000468007.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 524Poly-Ser

Phylogenomic databases

InParanoidiQ538Z0.
OrthoDBiEOG7D860T.

Sequencei

Sequence statusi: Complete.

Q538Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVISYALY QVQTGSLPVY SSVLTKSPLQ LQTVIYRLIV QIQHLNIPSS

SSTHSSPF
Length:58
Mass (Da):6,437
Last modified:May 24, 2005 - v1
Checksum:i565F242B0695373C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611627 mRNA. Translation: AAU14892.1.
AC015987 Genomic DNA. No translation available.
CCDSiCCDS59509.1.
RefSeqiNP_001122091.2. NM_001128619.2.
UniGeneiHs.602015.

Genome annotation databases

EnsembliENST00000589735; ENSP00000468007; ENSG00000267697.
GeneIDi767558.
KEGGihsa:767558.
UCSCiuc064iig.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611627 mRNA. Translation: AAU14892.1.
AC015987 Genomic DNA. No translation available.
CCDSiCCDS59509.1.
RefSeqiNP_001122091.2. NM_001128619.2.
UniGeneiHs.602015.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000468007.

PTM databases

iPTMnetiQ538Z0.
PhosphoSiteiQ538Z0.

Proteomic databases

PaxDbiQ538Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000589735; ENSP00000468007; ENSG00000267697.
GeneIDi767558.
KEGGihsa:767558.
UCSCiuc064iig.1. human.

Organism-specific databases

CTDi767558.
GeneCardsiLUZP6.
H-InvDBHIX0033575.
HGNCiHGNC:33955. LUZP6.
MIMi611050. gene.
neXtProtiNX_Q538Z0.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ538Z0.
OrthoDBiEOG7D860T.

Miscellaneous databases

GenomeRNAii767558.
PROiQ538Z0.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ538Z0. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions."
    Xiong Z., Liu E., Yan Y., Silver R.T., Yang F., Chen I.H., Chen Y., Verstovsek S., Wang H., Prchal J., Yang X.-F.
    J. Immunol. 177:4907-4916(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 39-58, TISSUE SPECIFICITY, INDUCTION, IDENTIFICATION AS A CANCER ANTIGEN.
    Tissue: Testis.

Entry informationi

Entry nameiLUZP6_HUMAN
AccessioniPrimary (citable) accession number: Q538Z0
Secondary accession number(s): K7EQW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 24, 2005
Last modified: June 8, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Elicits IgG antibody response in a subset of polycythemia vera patients and as well in patients with chronic myelogenous leukemia and prostate cancer receiving IFNA1 or other therapy, suggesting that it is broadly immunogenic.
This protein is produced by a bicistronic gene which also produces the MTPN protein from a non-overlapping reading frame. LUZP6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN that is expressed following IRES-mediated alternative initiation of translation at a AUU start codon.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.