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Protein

Leucine zipper protein 6

Gene

LUZP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

Elicits IgG antibody response in a subset of polycythemia vera patients and as well in patients with chronic myelogenous leukemia and prostate cancer receiving IFNA1 or other therapy, suggesting that it is broadly immunogenic.
This protein is produced by a bicistronic gene which also produces the MTPN protein from a non-overlapping reading frame. LUZP6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN that is expressed following IRES-mediated alternative initiation of translation at a AUU start codon.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper protein 6
Alternative name(s):
Myeloproliferative disease-associated 6 kDa antigen
Gene namesi
Name:LUZP6
Synonyms:MPD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000267697.1.
HGNCiHGNC:33955. LUZP6.

Pathology & Biotechi

Organism-specific databases

DisGeNETi767558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185781 – 58Leucine zipper protein 6Add BLAST58

Proteomic databases

PaxDbiQ538Z0.
PRIDEiQ538Z0.

PTM databases

iPTMnetiQ538Z0.
PhosphoSitePlusiQ538Z0.

Expressioni

Tissue specificityi

Widely expressed, highest levels found in brain, placenta, spleen, testis, and ovary. Up-regulated in some tumor cells.1 Publication

Inductioni

By IFNA1.1 Publication

Gene expression databases

BgeeiENSG00000267697.
GenevisibleiQ538Z0. HS.

Organism-specific databases

HPAiHPA077907.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000468007.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 52Poly-Ser4

Phylogenomic databases

InParanoidiQ538Z0.
OrthoDBiEOG091G14T6.

Sequencei

Sequence statusi: Complete.

Q538Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVISYALY QVQTGSLPVY SSVLTKSPLQ LQTVIYRLIV QIQHLNIPSS

SSTHSSPF
Length:58
Mass (Da):6,437
Last modified:May 24, 2005 - v1
Checksum:i565F242B0695373C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611627 mRNA. Translation: AAU14892.1.
AC015987 Genomic DNA. No translation available.
CCDSiCCDS59509.1.
RefSeqiNP_001122091.2. NM_001128619.2.
UniGeneiHs.602015.

Genome annotation databases

EnsembliENST00000589735; ENSP00000468007; ENSG00000267697.
GeneIDi767558.
KEGGihsa:767558.
UCSCiuc064iig.1. human.

Entry informationi

Entry nameiLUZP6_HUMAN
AccessioniPrimary (citable) accession number: Q538Z0
Secondary accession number(s): K7EQW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot