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Protein

Valine dehydrogenase

Gene

vdh

Organism
Streptomyces cinnamonensis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Oxidative deamination of branched-chain amino acids. The catabolism of valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors (By similarity).By similarity

Catalytic activityi

L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH.

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 194NADSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processBranched-chain amino acid catabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00362.

Names & Taxonomyi

Protein namesi
Recommended name:
Valine dehydrogenase (EC:1.4.1.-)
Short name:
ValDH
Gene namesi
Name:vdh
OrganismiStreptomyces cinnamonensis
Taxonomic identifieri1900 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001828121 – 358Valine dehydrogenaseAdd BLAST358

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ53872.
SMRiQ53872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR42722:SF1. PTHR42722:SF1. 1 hit.
PfamiView protein in Pfam
PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiView protein in SMART
SM00839. ELFV_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00074. GLFV_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEADNGVLH TLFHSDQGGH EQVVLCQDRA SGLKAVIAIH STALGPALGG
60 70 80 90 100
TRFYPYATEE EAVADVLNLS RGMSYKNAMA GLDHGGGKAV IIGDPEQIKS
110 120 130 140 150
EDLLLAFGRF VASLGGRYVT ACDVGTYVAD MDVVARECRW TTGRSPENGG
160 170 180 190 200
AGDSSVLTAF GVFQGMRASA EHLWGDPSLR GRKVGVAGVG KVGHHLVEHL
210 220 230 240 250
LEDGADVVIT DVREESVNRS THKHPSVTAV ADTEALIRTE GLDIYAPCAL
260 270 280 290 300
GGALDDDSVP VLTAKVVCGA ANNQLAHPGV EKDLADRSIL YAPDYVVNAG
310 320 330 340 350
GVIQVADELR GFDFDRCKAK ASKIFDTTLA IFARAKEDGI PPAAAADRIA

EQRMSDAR
Length:358
Mass (Da):37,750
Last modified:November 1, 1996 - v1
Checksum:iD629AB9518B0A74D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42212 Genomic DNA. Translation: AAC44587.1.
PIRiJC5176.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVDH_STRCM
AccessioniPrimary (citable) accession number: Q53872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families