ID   Q53839_STRCH            Unreviewed;       565 AA.
AC   Q53839;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=pk3 {ECO:0000313|EMBL:AAA61400.1};
OS   Streptomyces coelicolor.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1902 {ECO:0000313|EMBL:AAA61400.1};
RN   [1] {ECO:0000313|EMBL:AAA61400.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A3 {ECO:0000313|EMBL:AAA61400.1};
RA   Petricek M., Tichy P.;
RT   "Cloning and characterisation of a protein kinase-like gene (pks3) from
RT   Streptomyces coelicolor A3(2).";
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   EMBL; U19250; AAA61400.1; -; Genomic_DNA.
DR   RefSeq; NP_630931.1; NC_003888.3.
DR   RefSeq; WP_011031246.1; NZ_VNIH01000002.1.
DR   AlphaFoldDB; Q53839; -.
DR   MEROPS; C14.A07; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000313|EMBL:AAA61400.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000313|EMBL:AAA61400.1}.
FT   DOMAIN          298..561
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   565 AA;  60370 MW;  7FFB28A79055CD5A CRC64;
     MPLPSPDSSR VVLVGVADYD HLPPLPGIRN NLAALAEFFT SPQGWGLPPE HCTVVTNPCQ
     SSEFIDPVQR AAAEATDTLL VYYSGHGHLD DELRYSVSVT GSRQDQPWTC LPYSWLKSVL
     IQTRAQRRVV ILDSCFSGQA HGLMTDAADA LRVQVATSGA VVISSARHDL PALAPVGETY
     TAFTGELLDV LTHGIPGGSP EISVDAAYAH VKAALAARGR PTPDRTGTDT SGALIIARNP
     GFRPHTPAAT LRPVPGTHLR ALAERLYPLS ADARSSRRHT KPAEAGQRTE PDSAGERYEI
     LSPLGRGGMG TVSVAYDRLL DRRVALKSIE IYGGDEPFAR QVFWSEVRIA AALNHPNVAA
     IYDVVEGKTG RFFVMELVPG TDLSTAIKEG PLSPDQAAEV VHDVLSGLEA AHQRGVVHCD
     VKPGNIMLTP NGRIKILDFG VSHVIAEGEH GPLHRGDGTM VGTPLYMAPE TLLGQLPTVA
     ADIYGTGVVF YQLCTGRPPF PVSHFAEIAS LKHAGPPTPP SEIHPAVPAT YQTIIMRALE
     RDPKDRYSSA AEMRAAIAAA LYGAN
//