Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine protease SplC

Gene

splC

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemBy similarity
Active sitei113 – 1131Charge relay systemBy similarity
Active sitei193 – 1931Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.283.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease SplC (EC:3.4.21.-)
Gene namesi
Name:splC
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636By similarityAdd
BLAST
Chaini37 – 239203Serine protease SplCPRO_0000359551Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL1867.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AS9X-ray1.70A/B37-239[»]
ProteinModelPortaliQ53782.
SMRiQ53782. Positions 37-239.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53782.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108FN4. Bacteria.
COG3591. LUCA.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR001254. Trypsin_dom.
IPR028301. V8_his_AS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00672. V8_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKNIVIKSM AALAILTSVT GINAAVVEET QQIANAEKNV TQVKDTNNFP
60 70 80 90 100
YNGVVSFKDA TGFVIGKNTI ITNKHVSKDY KVGDRITAHP NGDKGNGGIY
110 120 130 140 150
KIKSISDYPG DEDISVMNIE EQAVERGPKG FNFNENVQAF NFAKDAKVDD
160 170 180 190 200
KIKVIGYPLP AQNSFKQFES TGTIKRIKDN ILNFDAYIEP GNSGSPVLNS
210 220 230
NNEVIGVVYG GIGKIGSEYN GAVYFTPQIK DFIQKHIEQ
Length:239
Mass (Da):26,099
Last modified:November 1, 1996 - v1
Checksum:iA56BB3CDB77B29A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63529 Genomic DNA. Translation: AAC12901.1.
RefSeqiWP_001038872.1. NZ_LIGW01000010.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63529 Genomic DNA. Translation: AAC12901.1.
RefSeqiWP_001038872.1. NZ_LIGW01000010.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AS9X-ray1.70A/B37-239[»]
ProteinModelPortaliQ53782.
SMRiQ53782. Positions 37-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL1867.

Protein family/group databases

MEROPSiS01.283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108FN4. Bacteria.
COG3591. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ53782.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR008256. Peptidase_S1B.
IPR008353. Peptidase_S1B_tx.
IPR001254. Trypsin_dom.
IPR028301. V8_his_AS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR01774. EXFOLTOXIN.
PR00839. V8PROTEASE.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00672. V8_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of a novel Staphylococcus aureus antigen."
    Rieneck K., Renneberg J., Diamant M., Gutschik E., Bendtzen K.
    Biochim. Biophys. Acta 1350:128-132(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FDA 485.

Entry informationi

Entry nameiSPLC_STAAU
AccessioniPrimary (citable) accession number: Q53782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.