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Q53752

- Q53752_STRAU

UniProt

Q53752 - Q53752_STRAU

Protein
Submitted name:

Ribonuclease

Gene

ribonuclease

Organism
Streptomyces aureofaciens
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei122 – 1221Proton donor/acceptorImported
    Sitei133 – 1331Transition state stabilizerImported
    Active sitei152 – 1521Proton donor/acceptorImported

    GO - Molecular functioni

    1. endoribonuclease activity Source: InterPro
    2. RNA binding Source: InterPro

    Keywords - Molecular functioni

    HydrolaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RibonucleaseImported (EC:3.1.4.8Imported)
    Gene namesi
    Name:ribonucleaseImported
    OrganismiStreptomyces aureofaciensImported
    Taxonomic identifieri1894 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-7136090.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PY3X-ray1.80A/B/C67-163[»]
    1PYLX-ray1.51A/B67-163[»]
    3D4AX-ray2.20A/B/C67-163[»]
    3D5GX-ray1.80A/B/C67-163[»]
    3D5IX-ray2.20A/B/C67-163[»]
    3DGYX-ray1.80A/B/C67-163[»]
    3DH2X-ray2.25A/B/C/D67-163[»]
    ProteinModelPortaliQ53752.
    SMRiQ53752. Positions 69-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ53752.

    Family & Domainsi

    Family and domain databases

    Gene3Di3.10.450.30. 1 hit.
    InterProiIPR000026. Gua-sp_ribonuclease_N1/T1.
    IPR016191. Ribonuclease/ribotoxin.
    [Graphical view]
    PfamiPF00545. Ribonuclease. 1 hit.
    [Graphical view]
    SUPFAMiSSF53933. SSF53933. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q53752-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRSKSPLVV GAVLILAVLA GVGYLLAGRG GSTHPKAAAS SAAAGTSAPK    50
    SSAPKPSPPA GGAWTPADPA LADVCRTKLP SQAQDTLALI AKNGPYPYNR 100
    DGVVFENRES RLPKKGNGYY HEFTVVTPGS NDRGTRRVVT GGYGEQYWSP 150
    DHYATFQEID PRC 163
    Length:163
    Mass (Da):17,099
    Last modified:November 1, 1996 - v1
    Checksum:i22DFAB7FE8727F9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88615 Genomic DNA. Translation: AAA26806.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88615 Genomic DNA. Translation: AAA26806.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PY3 X-ray 1.80 A/B/C 67-163 [» ]
    1PYL X-ray 1.51 A/B 67-163 [» ]
    3D4A X-ray 2.20 A/B/C 67-163 [» ]
    3D5G X-ray 1.80 A/B/C 67-163 [» ]
    3D5I X-ray 2.20 A/B/C 67-163 [» ]
    3DGY X-ray 1.80 A/B/C 67-163 [» ]
    3DH2 X-ray 2.25 A/B/C/D 67-163 [» ]
    ProteinModelPortali Q53752.
    SMRi Q53752. Positions 69-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-7136090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q53752.

    Family and domain databases

    Gene3Di 3.10.450.30. 1 hit.
    InterProi IPR000026. Gua-sp_ribonuclease_N1/T1.
    IPR016191. Ribonuclease/ribotoxin.
    [Graphical view ]
    Pfami PF00545. Ribonuclease. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53933. SSF53933. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Nazarov V., Sevcik J., Durcova G., Stanssens P.
      Submitted (MAR-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: R8/26Imported.
    2. "Crystal structure reveals two alternative conformations in the active site of ribonuclease Sa2."
      Sevcik J., Dauter Z., Wilson K.S.
      Acta Crystallogr. D 60:1198-1204(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 67-163, ACTIVE SITE.
    3. "Structure of RNase Sa2 complexes with mononucleotides--new aspects of catalytic reaction and substrate recognition."
      Bauerova-Hlinkova V., Dvorsky R., Perecko D., Povazanec F., Sevcik J.
      FEBS J. 276:4156-4168(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 67-163.

    Entry informationi

    Entry nameiQ53752_STRAU
    AccessioniPrimary (citable) accession number: Q53752
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3