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Q53752

- Q53752_STRAU

UniProt

Q53752 - Q53752_STRAU

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Protein
Submitted name:

Ribonuclease

Gene
ribonuclease
Organism
Streptomyces aureofaciens
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221Proton donor/acceptorImported
Sitei133 – 1331Transition state stabilizerImported
Active sitei152 – 1521Proton donor/acceptorImported

GO - Molecular functioni

  1. endoribonuclease activity Source: InterPro
  2. RNA binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
RibonucleaseImported (EC:3.1.4.8Imported)
Gene namesi
Name:ribonucleaseImported
OrganismiStreptomyces aureofaciensImported
Taxonomic identifieri1894 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Interactioni

Protein-protein interaction databases

MINTiMINT-7136090.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PY3X-ray1.80A/B/C67-163[»]
1PYLX-ray1.51A/B67-163[»]
3D4AX-ray2.20A/B/C67-163[»]
3D5GX-ray1.80A/B/C67-163[»]
3D5IX-ray2.20A/B/C67-163[»]
3DGYX-ray1.80A/B/C67-163[»]
3DH2X-ray2.25A/B/C/D67-163[»]
ProteinModelPortaliQ53752.
SMRiQ53752. Positions 69-163.

Miscellaneous databases

EvolutionaryTraceiQ53752.

Family & Domainsi

Family and domain databases

Gene3Di3.10.450.30. 1 hit.
InterProiIPR000026. Gua-sp_ribonuclease_N1/T1.
IPR016191. Ribonuclease/ribotoxin.
[Graphical view]
PfamiPF00545. Ribonuclease. 1 hit.
[Graphical view]
SUPFAMiSSF53933. SSF53933. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53752-1 [UniParc]FASTAAdd to Basket

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MTRSKSPLVV GAVLILAVLA GVGYLLAGRG GSTHPKAAAS SAAAGTSAPK    50
SSAPKPSPPA GGAWTPADPA LADVCRTKLP SQAQDTLALI AKNGPYPYNR 100
DGVVFENRES RLPKKGNGYY HEFTVVTPGS NDRGTRRVVT GGYGEQYWSP 150
DHYATFQEID PRC 163
Length:163
Mass (Da):17,099
Last modified:November 1, 1996 - v1
Checksum:i22DFAB7FE8727F9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88615 Genomic DNA. Translation: AAA26806.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88615 Genomic DNA. Translation: AAA26806.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PY3 X-ray 1.80 A/B/C 67-163 [» ]
1PYL X-ray 1.51 A/B 67-163 [» ]
3D4A X-ray 2.20 A/B/C 67-163 [» ]
3D5G X-ray 1.80 A/B/C 67-163 [» ]
3D5I X-ray 2.20 A/B/C 67-163 [» ]
3DGY X-ray 1.80 A/B/C 67-163 [» ]
3DH2 X-ray 2.25 A/B/C/D 67-163 [» ]
ProteinModelPortali Q53752.
SMRi Q53752. Positions 69-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-7136090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q53752.

Family and domain databases

Gene3Di 3.10.450.30. 1 hit.
InterProi IPR000026. Gua-sp_ribonuclease_N1/T1.
IPR016191. Ribonuclease/ribotoxin.
[Graphical view ]
Pfami PF00545. Ribonuclease. 1 hit.
[Graphical view ]
SUPFAMi SSF53933. SSF53933. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Nazarov V., Sevcik J., Durcova G., Stanssens P.
    Submitted (MAR-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: R8/26Imported.
  2. "Crystal structure reveals two alternative conformations in the active site of ribonuclease Sa2."
    Sevcik J., Dauter Z., Wilson K.S.
    Acta Crystallogr. D 60:1198-1204(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 67-163, ACTIVE SITE.
  3. "Structure of RNase Sa2 complexes with mononucleotides--new aspects of catalytic reaction and substrate recognition."
    Bauerova-Hlinkova V., Dvorsky R., Perecko D., Povazanec F., Sevcik J.
    FEBS J. 276:4156-4168(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 67-163.

Entry informationi

Entry nameiQ53752_STRAU
AccessioniPrimary (citable) accession number: Q53752
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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