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Protein

Phospholipase D

Gene
N/A
Organism
Streptomyces antibioticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.4.4. 5974.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D (EC:3.1.4.4)
Alternative name(s):
Choline phosphatase
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4747Add
BLAST
Chaini48 – 556509Phospholipase DPRO_0000024657Add
BLAST

Proteomic databases

PRIDEiQ53728.

Structurei

Secondary structure

1
556
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi54 – 6613Combined sources
Helixi68 – 703Combined sources
Turni72 – 743Combined sources
Beta strandi75 – 839Combined sources
Turni90 – 934Combined sources
Beta strandi94 – 985Combined sources
Helixi110 – 12415Combined sources
Beta strandi127 – 13711Combined sources
Helixi141 – 15616Combined sources
Beta strandi162 – 1687Combined sources
Helixi179 – 19012Combined sources
Helixi191 – 1966Combined sources
Beta strandi198 – 2047Combined sources
Turni208 – 2114Combined sources
Beta strandi212 – 2143Combined sources
Beta strandi218 – 2214Combined sources
Turni222 – 2243Combined sources
Beta strandi225 – 2306Combined sources
Helixi235 – 2384Combined sources
Beta strandi240 – 2434Combined sources
Beta strandi246 – 2549Combined sources
Helixi255 – 27319Combined sources
Helixi274 – 2763Combined sources
Turni278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Helixi295 – 3006Combined sources
Beta strandi309 – 3179Combined sources
Beta strandi321 – 3233Combined sources
Turni351 – 3533Combined sources
Helixi356 – 3616Combined sources
Helixi363 – 37311Combined sources
Beta strandi376 – 3849Combined sources
Turni390 – 3923Combined sources
Helixi398 – 40912Combined sources
Beta strandi413 – 4186Combined sources
Helixi421 – 4233Combined sources
Beta strandi426 – 4294Combined sources
Helixi439 – 45315Combined sources
Helixi456 – 46611Combined sources
Beta strandi467 – 4715Combined sources
Beta strandi474 – 4796Combined sources
Beta strandi491 – 4955Combined sources
Turni496 – 4983Combined sources
Beta strandi499 – 5046Combined sources
Beta strandi515 – 5206Combined sources
Helixi522 – 53110Combined sources
Helixi533 – 5408Combined sources
Helixi541 – 5433Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZE4X-ray2.50A48-556[»]
2ZE9X-ray2.30A48-556[»]
ProteinModelPortaliQ53728.
SMRiQ53728. Positions 51-551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53728.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 23728PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 51128PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDQRPARL PTHKGKLLAP HRLHRLIPVS VALTTVCAAL PSSTAYAADT
60 70 80 90 100
PPTPHLDAIE RSLRDTSPGL EGSVWQRTDG NRLDAPDGDP AGWLLQTPGC
110 120 130 140 150
WGDAGCKDRA GTRRLLDKMT RNIADARHTV DISSLAPFPN GGFEDAVVDG
160 170 180 190 200
LKAVVAAGHS PRVRILVGAA PIYHLNVVPS RYRDELIGKL GAAAGKVTLN
210 220 230 240 250
VASMTTSKTS LSWNHSKLLV VDGKTAITGG INGWKDDYLD TAHPVSDVDM
260 270 280 290 300
ALSGPAAASA GKYLDTLWDW TCRNASDPAK VWLATSNGAS CMPSMEQDEA
310 320 330 340 350
GSAPAEPTGD VPVIAVGGLG VGIKESDPSS GYHPDLPTAP DTKCTVGLHD
360 370 380 390 400
NTNADRDYDT VNPEENALRS LIASARSHVE ISQQDLNATC PPLPRYDIRT
410 420 430 440 450
YDTLAGKLAA GVKVRIVVSD PANRGAVGSG GYSQIKSLDE ISDTLRTRLV
460 470 480 490 500
ALTGDNEKAS RALCGNLQLA SFRSSDAAKW ADGKPYALHH KLVSVDDSAF
510 520 530 540 550
YIGSKNLYPA WLQDFGYIVE SPAAAQQLKT ELLDPEWKYS QQAAATPAGC

PARQAG
Length:556
Mass (Da):58,932
Last modified:November 1, 1996 - v1
Checksum:iB388F0BDC8C0A596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16444 Genomic DNA. Translation: BAA03913.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16444 Genomic DNA. Translation: BAA03913.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZE4X-ray2.50A48-556[»]
2ZE9X-ray2.30A48-556[»]
ProteinModelPortaliQ53728.
SMRiQ53728. Positions 51-551.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ53728.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.1.4.4. 5974.

Miscellaneous databases

EvolutionaryTraceiQ53728.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLD_STRAT
AccessioniPrimary (citable) accession number: Q53728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 14, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.