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Protein
Submitted name:

MecA PBP2' (penicillin binding protein 2')

Gene

mecA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MecA PBP2' (penicillin binding protein 2')Imported
Submitted name:
PBP2AImported
Gene namesi
Name:mecAImported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2418HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2363021.
DrugBankiDB01332. Ceftizoxime.
DB01603. Meticillin.
DB00417. Phenoxymethylpenicillin.

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0033.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 140115MecA_NInterPro annotationAdd
BLAST
Domaini148 – 309162PBP_dimerInterPro annotationAdd
BLAST
Domaini346 – 657312TranspeptidaseInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4107RVG. Bacteria.
COG0768. LUCA.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR032710. NTF2-like_dom.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIKIVPLI LIVVVVGFGI YFYASKDKEI NNTIDAIEDK NFKQVYKDSS
60 70 80 90 100
YISKSDNGEV EMTERPIKIY NSLGVKDINI QDRKIKKVSK NKKRVDAQYK
110 120 130 140 150
IKTNYGNIDR NVQFNFVKED GMWKLDWDHS VIIPGMQKDQ SIHIENLKSE
160 170 180 190 200
RGKILDRNNV ELANTGTHMR LGIVPKNVSK KDYKAIAKEL SISEDYINNK
210 220 230 240 250
WIKIGYKMIP SFHFKTVKKM DEYLSDFAKK FHLTTNETES RNYPLEKATS
260 270 280 290 300
HLLGYVGPIN SEELKQKEYK GYKDDAVIGK KGLEKLYDKK LQHEDGYRVT
310 320 330 340 350
IVDDNSNTIA HTLIEKKKKD GKDIQLTIDA KVQKSIYNNM KNDYGSGTAI
360 370 380 390 400
HPQTGELLAL VSTPSYDVYP FMYGMSNEEY NKLTEDKKEP LLNKFQITTS
410 420 430 440 450
PGSTQKILTA MIGLNNKTLD DKTSYKIDGK GWQKDKSWGG YNVTRYEVVN
460 470 480 490 500
GNIDLKQAIE SSDNIFFARV ALELGSKKFE KGMKKLGVGE DIPSDYPFYN
510 520 530 540 550
AQISNKNLDN EILLADSGYG QGEILINPVQ ILSIYSALEN NGNINAPHLL
560 570 580 590 600
KDTKNKVWKK NIISKENINL LNDGMQQVVN KTHKEDIYRS YANLIGKSGT
610 620 630 640 650
AELKMKQGES GRQIGWFISY DKDNPNMMMA INVKDVQDKG MASYNAKISG
660
KVYDELYENG NKKYDIDE
Length:668
Mass (Da):76,266
Last modified:November 1, 1996 - v1
Checksum:i5E58F2572B359EEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52593 Genomic DNA. Translation: CAA36829.1.
Y14051 Genomic DNA. Translation: CAA74376.1.
PIRiJQ0773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52593 Genomic DNA. Translation: CAA36829.1.
Y14051 Genomic DNA. Translation: CAA74376.1.
PIRiJQ0773.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0033.

Chemistry

ChEMBLiCHEMBL2363021.
DrugBankiDB01332. Ceftizoxime.
DB01603. Meticillin.
DB00417. Phenoxymethylpenicillin.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107RVG. Bacteria.
COG0768. LUCA.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR032710. NTF2-like_dom.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence comparison of mecA genes isolated from methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis."
    Ryffel C., Tesch W., Birch-Machin I., Reynolds P.E., Barberis-Maino L., Kayser F.H., Berger-Bachi B.
    Gene 94:137-138(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NCTC8325Imported.
  2. "Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri."
    Wu S., de Lencastre H., Tomasz A.
    J. Bacteriol. 180:236-242(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BB270Imported and BMS-1Imported.

Entry informationi

Entry nameiQ53707_STAAU
AccessioniPrimary (citable) accession number: Q53707
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.