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Protein

Oleandomycin glycosyltransferase

Gene

oleD

Organism
Streptomyces antibioticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Specifically inactivates oleandomycin via 2'-O-glycosylation using UDP-glucose.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17058.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Oleandomycin glycosyltransferase (EC:2.4.1.-)
Gene namesi
Name:oleD
Synonyms:UGT102A2
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Oleandomycin glycosyltransferasePRO_0000074165Add
BLAST

Structurei

Secondary structure

1
430
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 135Combined sources
Helixi18 – 203Combined sources
Helixi22 – 243Combined sources
Helixi25 – 3410Combined sources
Beta strandi37 – 426Combined sources
Helixi44 – 463Combined sources
Helixi47 – 515Combined sources
Turni52 – 543Combined sources
Beta strandi56 – 594Combined sources
Beta strandi67 – 693Combined sources
Helixi71 – 744Combined sources
Helixi78 – 10124Combined sources
Beta strandi106 – 1116Combined sources
Helixi115 – 12410Combined sources
Beta strandi128 – 1347Combined sources
Helixi141 – 1444Combined sources
Helixi146 – 1549Combined sources
Helixi157 – 17216Combined sources
Helixi179 – 1846Combined sources
Beta strandi187 – 1915Combined sources
Helixi195 – 1973Combined sources
Helixi201 – 2033Combined sources
Turni206 – 2083Combined sources
Beta strandi209 – 2113Combined sources
Beta strandi232 – 2376Combined sources
Turni240 – 2423Combined sources
Helixi247 – 25711Combined sources
Beta strandi263 – 2686Combined sources
Beta strandi271 – 2733Combined sources
Helixi275 – 2784Combined sources
Beta strandi285 – 2895Combined sources
Helixi293 – 2975Combined sources
Beta strandi301 – 3055Combined sources
Helixi309 – 3179Combined sources
Beta strandi322 – 3243Combined sources
Helixi329 – 3313Combined sources
Helixi332 – 3409Combined sources
Beta strandi343 – 3464Combined sources
Turni349 – 3513Combined sources
Helixi354 – 36512Combined sources
Helixi368 – 38417Combined sources
Helixi387 – 39711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IYFX-ray1.70A/B1-413[»]
4M60X-ray1.77A1-413[»]
4M7PX-ray1.77A1-413[»]
4M83X-ray1.70A/B1-413[»]
ProteinModelPortaliQ53685.
SMRiQ53685. Positions 6-399.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53685.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
IPR006326. UDPGT_MGT.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 2 hits.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01426. MGT. 1 hit.
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQTTPAHI AMFSIAAHGH VNPSLEVIRE LVARGHRVTY AIPPVFADKV
60 70 80 90 100
AATGPRPVLY HSTLPGPDAD PEAWGSTLLD NRRTFLNDAI QALPQLADAY
110 120 130 140 150
ADDIPDLVLH DITSYPARVL ARRWGVPAVS LSPNLVAWKG YEEEVAEPMW
160 170 180 190 200
REPRQTERGR AYYARFEAWL KENGITEHPD TFASHPPRSL VLIPKALQPH
210 220 230 240 250
ADRVDEDVYT FVGACQGDRA EEGGWQRPAG AEKVVLVSLG SAFTKQPAFY
260 270 280 290 300
RECVRAFGNL PGWHLVLQIG RKVTPAELGE LPDNVEVHDW VPQLAILRQA
310 320 330 340 350
DLFVTHAGAG GSQEGLATAT PMIAVPQAVD QFGNADMLQG LGVARKLATE
360 370 380 390 400
EATADLLRET ALALVDDPEV ARRLRRIQAE MAQEGGTRRA ADLIEAELPA
410 420 430
RHERQEPVGD RPNVGDRPAG VRSDRQRSAL
Length:430
Mass (Da):47,136
Last modified:November 1, 1997 - v1
Checksum:i320512217B42A0B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22577 Genomic DNA. Translation: CAA80301.1.
PIRiS33184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22577 Genomic DNA. Translation: CAA80301.1.
PIRiS33184.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IYFX-ray1.70A/B1-413[»]
4M60X-ray1.77A1-413[»]
4M7PX-ray1.77A1-413[»]
4M83X-ray1.70A/B1-413[»]
ProteinModelPortaliQ53685.
SMRiQ53685. Positions 6-399.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17058.

Miscellaneous databases

EvolutionaryTraceiQ53685.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
IPR006326. UDPGT_MGT.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 2 hits.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01426. MGT. 1 hit.
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOLED_STRAT
AccessioniPrimary (citable) accession number: Q53685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.