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Protein

Oleandomycin glycosyltransferase

Gene

oleD

Organism
Streptomyces antibioticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Specifically inactivates oleandomycin via 2'-O-glycosylation using UDP-glucose.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17058.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Oleandomycin glycosyltransferase (EC:2.4.1.-)
Gene namesi
Name:oleD
Synonyms:UGT102A2
OrganismiStreptomyces antibioticus
Taxonomic identifieri1890 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741651 – 430Oleandomycin glycosyltransferaseAdd BLAST430

Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 13Combined sources5
Helixi18 – 20Combined sources3
Helixi22 – 24Combined sources3
Helixi25 – 34Combined sources10
Beta strandi37 – 42Combined sources6
Helixi44 – 46Combined sources3
Helixi47 – 51Combined sources5
Turni52 – 54Combined sources3
Beta strandi56 – 59Combined sources4
Beta strandi67 – 69Combined sources3
Helixi71 – 74Combined sources4
Helixi78 – 101Combined sources24
Beta strandi106 – 111Combined sources6
Helixi115 – 124Combined sources10
Beta strandi128 – 134Combined sources7
Helixi141 – 144Combined sources4
Helixi146 – 154Combined sources9
Helixi157 – 172Combined sources16
Helixi179 – 184Combined sources6
Beta strandi187 – 191Combined sources5
Helixi195 – 197Combined sources3
Helixi201 – 203Combined sources3
Turni206 – 208Combined sources3
Beta strandi209 – 211Combined sources3
Beta strandi232 – 237Combined sources6
Turni240 – 242Combined sources3
Helixi247 – 257Combined sources11
Beta strandi263 – 268Combined sources6
Beta strandi271 – 273Combined sources3
Helixi275 – 278Combined sources4
Beta strandi285 – 289Combined sources5
Helixi293 – 297Combined sources5
Beta strandi301 – 305Combined sources5
Helixi309 – 317Combined sources9
Beta strandi322 – 324Combined sources3
Helixi329 – 331Combined sources3
Helixi332 – 340Combined sources9
Beta strandi343 – 346Combined sources4
Turni349 – 351Combined sources3
Helixi354 – 365Combined sources12
Helixi368 – 384Combined sources17
Helixi387 – 397Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IYFX-ray1.70A/B1-413[»]
4M60X-ray1.77A1-413[»]
4M7PX-ray1.77A1-413[»]
4M83X-ray1.70A/B1-413[»]
ProteinModelPortaliQ53685.
SMRiQ53685.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53685.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
IPR006326. UDPGT_MGT.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 2 hits.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01426. MGT. 1 hit.
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQTTPAHI AMFSIAAHGH VNPSLEVIRE LVARGHRVTY AIPPVFADKV
60 70 80 90 100
AATGPRPVLY HSTLPGPDAD PEAWGSTLLD NRRTFLNDAI QALPQLADAY
110 120 130 140 150
ADDIPDLVLH DITSYPARVL ARRWGVPAVS LSPNLVAWKG YEEEVAEPMW
160 170 180 190 200
REPRQTERGR AYYARFEAWL KENGITEHPD TFASHPPRSL VLIPKALQPH
210 220 230 240 250
ADRVDEDVYT FVGACQGDRA EEGGWQRPAG AEKVVLVSLG SAFTKQPAFY
260 270 280 290 300
RECVRAFGNL PGWHLVLQIG RKVTPAELGE LPDNVEVHDW VPQLAILRQA
310 320 330 340 350
DLFVTHAGAG GSQEGLATAT PMIAVPQAVD QFGNADMLQG LGVARKLATE
360 370 380 390 400
EATADLLRET ALALVDDPEV ARRLRRIQAE MAQEGGTRRA ADLIEAELPA
410 420 430
RHERQEPVGD RPNVGDRPAG VRSDRQRSAL
Length:430
Mass (Da):47,136
Last modified:November 1, 1997 - v1
Checksum:i320512217B42A0B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22577 Genomic DNA. Translation: CAA80301.1.
PIRiS33184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22577 Genomic DNA. Translation: CAA80301.1.
PIRiS33184.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IYFX-ray1.70A/B1-413[»]
4M60X-ray1.77A1-413[»]
4M7PX-ray1.77A1-413[»]
4M83X-ray1.70A/B1-413[»]
ProteinModelPortaliQ53685.
SMRiQ53685.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17058.

Miscellaneous databases

EvolutionaryTraceiQ53685.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
IPR006326. UDPGT_MGT.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 2 hits.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01426. MGT. 1 hit.
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOLED_STRAT
AccessioniPrimary (citable) accession number: Q53685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.