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Protein

Collagen adhesin

Gene

cna

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates attachment of staphylococcal cells to collagen-containing substrata.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei209Autocatalyzes isopeptide 176-293 formationSequence analysis1
Sitei601Autocatalyzes isopeptide 541-618 formationSequence analysis1
Sitei692Autocatalyzes isopeptide 631-715 formationSequence analysis1
Sitei788Autocatalyzes isopeptide 728-805 formationSequence analysis1
Sitei879Autocatalyzes isopeptide 818-902 formationSequence analysis1
Sitei975Autocatalyzes isopeptide 915-992 formationSequence analysis1
Sitei1066Autocatalyzes isopeptide 1005-1089 formationSequence analysis1

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen adhesin
Gene namesi
Name:cna
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-KW
  • peptidoglycan-based cell wall Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000559930 – 1154Collagen adhesinAdd BLAST1125
PropeptideiPRO_00000056001155 – 1183Removed by sortaseSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki176 ↔ 293Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki541 ↔ 618Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki631 ↔ 715Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki728 ↔ 805Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki818 ↔ 902Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki915 ↔ 992Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki1005 ↔ 1089Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Modified residuei1154Pentaglycyl murein peptidoglycan amidated threonineSequence analysis1

Keywords - PTMi

Isopeptide bond, Peptidoglycan-anchor

Proteomic databases

PRIDEiQ53654.

Structurei

Secondary structure

11183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 37Combined sources4
Beta strandi38 – 48Combined sources11
Beta strandi52 – 65Combined sources14
Beta strandi71 – 76Combined sources6
Beta strandi80 – 87Combined sources8
Beta strandi90 – 96Combined sources7
Beta strandi99 – 107Combined sources9
Beta strandi110 – 115Combined sources6
Helixi117 – 119Combined sources3
Beta strandi123 – 139Combined sources17
Beta strandi148 – 153Combined sources6
Beta strandi156 – 162Combined sources7
Beta strandi175 – 177Combined sources3
Beta strandi185 – 194Combined sources10
Beta strandi201 – 203Combined sources3
Beta strandi205 – 211Combined sources7
Beta strandi215 – 217Combined sources3
Helixi219 – 221Combined sources3
Beta strandi224 – 228Combined sources5
Beta strandi232 – 234Combined sources3
Beta strandi236 – 238Combined sources3
Helixi239 – 246Combined sources8
Turni247 – 249Combined sources3
Beta strandi251 – 255Combined sources5
Turni256 – 259Combined sources4
Beta strandi260 – 265Combined sources6
Helixi267 – 270Combined sources4
Beta strandi273 – 284Combined sources12
Beta strandi289 – 299Combined sources11
Beta strandi307 – 311Combined sources5
Beta strandi314 – 317Combined sources4
Beta strandi321 – 328Combined sources8
Beta strandi534 – 545Combined sources12
Turni546 – 550Combined sources5
Beta strandi555 – 563Combined sources9
Beta strandi566 – 574Combined sources9
Helixi575 – 577Combined sources3
Beta strandi580 – 590Combined sources11
Beta strandi597 – 601Combined sources5
Beta strandi607 – 612Combined sources6
Beta strandi615 – 620Combined sources6
Beta strandi624 – 636Combined sources13
Beta strandi639 – 641Combined sources3
Beta strandi647 – 653Combined sources7
Beta strandi656 – 665Combined sources10
Helixi666 – 668Combined sources3
Beta strandi671 – 681Combined sources11
Beta strandi688 – 692Combined sources5
Beta strandi699 – 704Combined sources6
Beta strandi710 – 717Combined sources8
Beta strandi721 – 732Combined sources12
Turni733 – 737Combined sources5
Beta strandi744 – 750Combined sources7
Beta strandi753 – 760Combined sources8
Helixi762 – 764Combined sources3
Beta strandi766 – 777Combined sources12
Beta strandi784 – 788Combined sources5
Beta strandi794 – 799Combined sources6
Beta strandi802 – 807Combined sources6
Beta strandi811 – 822Combined sources12
Helixi823 – 825Combined sources3
Beta strandi832 – 840Combined sources9
Beta strandi843 – 852Combined sources10
Turni853 – 857Combined sources5
Beta strandi858 – 868Combined sources11
Beta strandi875 – 879Combined sources5
Beta strandi886 – 891Combined sources6
Helixi895 – 897Combined sources3
Beta strandi898 – 904Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AMXX-ray2.00A151-318[»]
1D2OX-ray2.00A/B533-719[»]
1D2PX-ray2.50A533-905[»]
2F68X-ray1.95X30-334[»]
2F6AX-ray3.29A/B/C/D30-330[»]
DisProtiDP00098.
ProteinModelPortaliQ53654.
SMRiQ53654.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati533 – 719B1Add BLAST187
Repeati720 – 906B2Add BLAST187
Repeati907 – 1093B3Add BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 318Collagen-bindingAdd BLAST168
Regioni533 – 10933 X 187 AA approximate tandem repeatsAdd BLAST561

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1151 – 1155LPXTG sorting signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1093 – 1157Lys/Pro-richAdd BLAST65

Keywords - Domaini

Repeat, Signal

Family and domain databases

CDDicd00222. CollagenBindB. 6 hits.
Gene3Di2.60.40.1140. 7 hits.
2.60.40.740. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR008970. Collagen-bd_Cna_B-typ_dom.
IPR008456. Collagen-bd_dom.
IPR032332. GramPos_pilinD3.
[Graphical view]
PfamiPF05738. Cna_B. 7 hits.
PF05737. Collagen_bind. 1 hit.
PF16570. GramPos_pilinD3. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKNVLKFMV FIMLLNIITP LFNKNEAFAA RDISSTNVTD LTVSPSKIED
60 70 80 90 100
GGKTTVKMTF DDKNGKIQNG DMIKVAWPTS GTVKIEGYSK TVPLTVKGEQ
110 120 130 140 150
VGQAVITPDG ATITFNDKVE KLSDVSGFAE FEVQGRNLTQ TNTSDDKVAT
160 170 180 190 200
ITSGNKSTNV TVHKSEAGTS SVFYYKTGDM LPEDTTHVRW FLNINNEKSY
210 220 230 240 250
VSKDITIKDQ IQGGQQLDLS TLNINVTGTH SNYYSGQSAI TDFEKAFPGS
260 270 280 290 300
KITVDNTKNT IDVTIPQGYG SYNSFSINYK TKITNEQQKE FVNNSQAWYQ
310 320 330 340 350
EHGKEEVNGK SFNHTVHNIN ANAGIEGTVK GELKVLKQDK DTKAPIANVK
360 370 380 390 400
FKLSKKDGSV VKDNQKEIEI ITDANGIANI KALPSGDYIL KEIEAPRPYT
410 420 430 440 450
FDKDKEYPFT MKDTDNQGYF TTIENAKAIE KTKDVSAQKV WEGTQKVKPT
460 470 480 490 500
IYFKLYKQDD NQNTTPVDKA EIKKLEDGTT KVTWSNLPEN DKNGKAIKYL
510 520 530 540 550
VKEVNAQGED TTPEGYTKKE NGLVVTNTEK PIETTSISGE KVWDDKDNQD
560 570 580 590 600
GKRPEKVSVN LLANGEKVKT LDVTSETNWK YEFKDLPKYD EGKKIEYTVT
610 620 630 640 650
EDHVKDYTTD INGTTITNKY TPGETSATVT KNWDDNNNQD GKRPTEIKVE
660 670 680 690 700
LYQDGKATGK TAILNESNNW THTWTGLDEK AKGQQVKYTV EELTKVKGYT
710 720 730 740 750
THVDNNDMGN LIVTNKYTPE TTSISGEKVW DDKDNQDGKR PEKVSVNLLA
760 770 780 790 800
DGEKVKTLDV TSETNWKYEF KDLPKYDEGK KIEYTVTEDH VKDYTTDING
810 820 830 840 850
TTITNKYTPG ETSATVTKNW DDNNNQDGKR PTEIKVELYQ DGKATGKTAI
860 870 880 890 900
LNESNNWTHT WTGLDEKAKG QQVKYTVEEL TKVKGYTTHV DNNDMGNLIV
910 920 930 940 950
TNKYTPETTS ISGEKVWDDK DNQDGKRPEK VSVNLLANGE KVKTLDVTSE
960 970 980 990 1000
TNWKYEFKDL PKYDEGKKIE YTVTEDHVKD YTTDINGTTI TNKYTPGETS
1010 1020 1030 1040 1050
ATVTKNWDDN NNQDGKRPTE IKVELYQDGK ATGKTAILNE SNNWTHTWTG
1060 1070 1080 1090 1100
LDEKAKGQQV KYTVDELTKV NGYTTHVDNN DMGNLIVTNK YTPKKPNKPI
1110 1120 1130 1140 1150
YPEKPKDKTP PTKPDHSNKV KPTPPDKPSK VDKDDQPKDN KTKPENPLKE
1160 1170 1180
LPKTGMKIIT SWITWVFIGI LGLYLILRKR FNS
Length:1,183
Mass (Da):133,067
Last modified:November 1, 1996 - v1
Checksum:iB6A1CC072E575D76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81736 Genomic DNA. Translation: AAA20874.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81736 Genomic DNA. Translation: AAA20874.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AMXX-ray2.00A151-318[»]
1D2OX-ray2.00A/B533-719[»]
1D2PX-ray2.50A533-905[»]
2F68X-ray1.95X30-334[»]
2F6AX-ray3.29A/B/C/D30-330[»]
DisProtiDP00098.
ProteinModelPortaliQ53654.
SMRiQ53654.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ53654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ53654.
PROiQ53654.

Family and domain databases

CDDicd00222. CollagenBindB. 6 hits.
Gene3Di2.60.40.1140. 7 hits.
2.60.40.740. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR008970. Collagen-bd_Cna_B-typ_dom.
IPR008456. Collagen-bd_dom.
IPR032332. GramPos_pilinD3.
[Graphical view]
PfamiPF05738. Cna_B. 7 hits.
PF05737. Collagen_bind. 1 hit.
PF16570. GramPos_pilinD3. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCNA_STAAU
AccessioniPrimary (citable) accession number: Q53654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.