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Protein

Collagen adhesin

Gene

cna

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates attachment of staphylococcal cells to collagen-containing substrata.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei209 – 2091Autocatalyzes isopeptide 176-293 formationSequence analysis
Sitei601 – 6011Autocatalyzes isopeptide 541-618 formationSequence analysis
Sitei692 – 6921Autocatalyzes isopeptide 631-715 formationSequence analysis
Sitei788 – 7881Autocatalyzes isopeptide 728-805 formationSequence analysis
Sitei879 – 8791Autocatalyzes isopeptide 818-902 formationSequence analysis
Sitei975 – 9751Autocatalyzes isopeptide 915-992 formationSequence analysis
Sitei1066 – 10661Autocatalyzes isopeptide 1005-1089 formationSequence analysis

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen adhesin
Gene namesi
Name:cna
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-KW
  • peptidoglycan-based cell wall Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 11541125Collagen adhesinPRO_0000005599Add
BLAST
Propeptidei1155 – 118329Removed by sortaseSequence analysisPRO_0000005600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki176 ↔ 293Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki541 ↔ 618Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki631 ↔ 715Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki728 ↔ 805Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki818 ↔ 902Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki915 ↔ 992Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Cross-linki1005 ↔ 1089Isoaspartyl lysine isopeptide (Lys-Asn)Sequence analysis
Modified residuei1154 – 11541Pentaglycyl murein peptidoglycan amidated threonineSequence analysis

Keywords - PTMi

Isopeptide bond, Peptidoglycan-anchor

Proteomic databases

PRIDEiQ53654.

Structurei

Secondary structure

1
1183
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 374Combined sources
Beta strandi38 – 4811Combined sources
Beta strandi52 – 6514Combined sources
Beta strandi71 – 766Combined sources
Beta strandi80 – 878Combined sources
Beta strandi90 – 967Combined sources
Beta strandi99 – 1079Combined sources
Beta strandi110 – 1156Combined sources
Helixi117 – 1193Combined sources
Beta strandi123 – 13917Combined sources
Beta strandi148 – 1536Combined sources
Beta strandi156 – 1627Combined sources
Beta strandi175 – 1773Combined sources
Beta strandi185 – 19410Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi205 – 2117Combined sources
Beta strandi215 – 2173Combined sources
Helixi219 – 2213Combined sources
Beta strandi224 – 2285Combined sources
Beta strandi232 – 2343Combined sources
Beta strandi236 – 2383Combined sources
Helixi239 – 2468Combined sources
Turni247 – 2493Combined sources
Beta strandi251 – 2555Combined sources
Turni256 – 2594Combined sources
Beta strandi260 – 2656Combined sources
Helixi267 – 2704Combined sources
Beta strandi273 – 28412Combined sources
Beta strandi289 – 29911Combined sources
Beta strandi307 – 3115Combined sources
Beta strandi314 – 3174Combined sources
Beta strandi321 – 3288Combined sources
Beta strandi534 – 54512Combined sources
Turni546 – 5505Combined sources
Beta strandi555 – 5639Combined sources
Beta strandi566 – 5749Combined sources
Helixi575 – 5773Combined sources
Beta strandi580 – 59011Combined sources
Beta strandi597 – 6015Combined sources
Beta strandi607 – 6126Combined sources
Beta strandi615 – 6206Combined sources
Beta strandi624 – 63613Combined sources
Beta strandi639 – 6413Combined sources
Beta strandi647 – 6537Combined sources
Beta strandi656 – 66510Combined sources
Helixi666 – 6683Combined sources
Beta strandi671 – 68111Combined sources
Beta strandi688 – 6925Combined sources
Beta strandi699 – 7046Combined sources
Beta strandi710 – 7178Combined sources
Beta strandi721 – 73212Combined sources
Turni733 – 7375Combined sources
Beta strandi744 – 7507Combined sources
Beta strandi753 – 7608Combined sources
Helixi762 – 7643Combined sources
Beta strandi766 – 77712Combined sources
Beta strandi784 – 7885Combined sources
Beta strandi794 – 7996Combined sources
Beta strandi802 – 8076Combined sources
Beta strandi811 – 82212Combined sources
Helixi823 – 8253Combined sources
Beta strandi832 – 8409Combined sources
Beta strandi843 – 85210Combined sources
Turni853 – 8575Combined sources
Beta strandi858 – 86811Combined sources
Beta strandi875 – 8795Combined sources
Beta strandi886 – 8916Combined sources
Helixi895 – 8973Combined sources
Beta strandi898 – 9047Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AMXX-ray2.00A151-318[»]
1D2OX-ray2.00A/B533-719[»]
1D2PX-ray2.50A533-905[»]
2F68X-ray1.95X30-334[»]
2F6AX-ray3.29A/B/C/D30-330[»]
DisProtiDP00098.
ProteinModelPortaliQ53654.
SMRiQ53654. Positions 31-329, 483-1094.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati533 – 719187B1Add
BLAST
Repeati720 – 906187B2Add
BLAST
Repeati907 – 1093187B3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 318168Collagen-bindingAdd
BLAST
Regioni533 – 10935613 X 187 AA approximate tandem repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1151 – 11555LPXTG sorting signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1093 – 115765Lys/Pro-richAdd
BLAST

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.1140. 7 hits.
2.60.40.740. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR008970. Collagen-bd_Cna_B-typ_dom.
IPR008456. Collagen-bd_dom.
[Graphical view]
PfamiPF05738. Cna_B. 1 hit.
PF05737. Collagen_bind. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKNVLKFMV FIMLLNIITP LFNKNEAFAA RDISSTNVTD LTVSPSKIED
60 70 80 90 100
GGKTTVKMTF DDKNGKIQNG DMIKVAWPTS GTVKIEGYSK TVPLTVKGEQ
110 120 130 140 150
VGQAVITPDG ATITFNDKVE KLSDVSGFAE FEVQGRNLTQ TNTSDDKVAT
160 170 180 190 200
ITSGNKSTNV TVHKSEAGTS SVFYYKTGDM LPEDTTHVRW FLNINNEKSY
210 220 230 240 250
VSKDITIKDQ IQGGQQLDLS TLNINVTGTH SNYYSGQSAI TDFEKAFPGS
260 270 280 290 300
KITVDNTKNT IDVTIPQGYG SYNSFSINYK TKITNEQQKE FVNNSQAWYQ
310 320 330 340 350
EHGKEEVNGK SFNHTVHNIN ANAGIEGTVK GELKVLKQDK DTKAPIANVK
360 370 380 390 400
FKLSKKDGSV VKDNQKEIEI ITDANGIANI KALPSGDYIL KEIEAPRPYT
410 420 430 440 450
FDKDKEYPFT MKDTDNQGYF TTIENAKAIE KTKDVSAQKV WEGTQKVKPT
460 470 480 490 500
IYFKLYKQDD NQNTTPVDKA EIKKLEDGTT KVTWSNLPEN DKNGKAIKYL
510 520 530 540 550
VKEVNAQGED TTPEGYTKKE NGLVVTNTEK PIETTSISGE KVWDDKDNQD
560 570 580 590 600
GKRPEKVSVN LLANGEKVKT LDVTSETNWK YEFKDLPKYD EGKKIEYTVT
610 620 630 640 650
EDHVKDYTTD INGTTITNKY TPGETSATVT KNWDDNNNQD GKRPTEIKVE
660 670 680 690 700
LYQDGKATGK TAILNESNNW THTWTGLDEK AKGQQVKYTV EELTKVKGYT
710 720 730 740 750
THVDNNDMGN LIVTNKYTPE TTSISGEKVW DDKDNQDGKR PEKVSVNLLA
760 770 780 790 800
DGEKVKTLDV TSETNWKYEF KDLPKYDEGK KIEYTVTEDH VKDYTTDING
810 820 830 840 850
TTITNKYTPG ETSATVTKNW DDNNNQDGKR PTEIKVELYQ DGKATGKTAI
860 870 880 890 900
LNESNNWTHT WTGLDEKAKG QQVKYTVEEL TKVKGYTTHV DNNDMGNLIV
910 920 930 940 950
TNKYTPETTS ISGEKVWDDK DNQDGKRPEK VSVNLLANGE KVKTLDVTSE
960 970 980 990 1000
TNWKYEFKDL PKYDEGKKIE YTVTEDHVKD YTTDINGTTI TNKYTPGETS
1010 1020 1030 1040 1050
ATVTKNWDDN NNQDGKRPTE IKVELYQDGK ATGKTAILNE SNNWTHTWTG
1060 1070 1080 1090 1100
LDEKAKGQQV KYTVDELTKV NGYTTHVDNN DMGNLIVTNK YTPKKPNKPI
1110 1120 1130 1140 1150
YPEKPKDKTP PTKPDHSNKV KPTPPDKPSK VDKDDQPKDN KTKPENPLKE
1160 1170 1180
LPKTGMKIIT SWITWVFIGI LGLYLILRKR FNS
Length:1,183
Mass (Da):133,067
Last modified:November 1, 1996 - v1
Checksum:iB6A1CC072E575D76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81736 Genomic DNA. Translation: AAA20874.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81736 Genomic DNA. Translation: AAA20874.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AMXX-ray2.00A151-318[»]
1D2OX-ray2.00A/B533-719[»]
1D2PX-ray2.50A533-905[»]
2F68X-ray1.95X30-334[»]
2F6AX-ray3.29A/B/C/D30-330[»]
DisProtiDP00098.
ProteinModelPortaliQ53654.
SMRiQ53654. Positions 31-329, 483-1094.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ53654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ53654.
PROiQ53654.

Family and domain databases

Gene3Di2.60.40.1140. 7 hits.
2.60.40.740. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR008454. Collagen-bd_Cna-like_B-typ_dom.
IPR008970. Collagen-bd_Cna_B-typ_dom.
IPR008456. Collagen-bd_dom.
[Graphical view]
PfamiPF05738. Cna_B. 1 hit.
PF05737. Collagen_bind. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCNA_STAAU
AccessioniPrimary (citable) accession number: Q53654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.