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Q53609

- MTS1_STRAL

UniProt

Q53609 - MTS1_STRAL

Protein

Modification methylase SalI

Gene

salIM

Organism
Streptomyces albus G
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GTCGAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the SalI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3491. M.SalI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase SalI (EC:2.1.1.72)
    Short name:
    M.SalI
    Alternative name(s):
    Adenine-specific methyltransferase SalI
    Gene namesi
    Name:salIM
    OrganismiStreptomyces albus G
    Taxonomic identifieri1962 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Modification methylase SalIPRO_0000087979Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ53609.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR024412. Lsr2.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF11774. Lsr2. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    ProDomiPD026347. PD026347. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q53609-1 [UniParc]FASTAAdd to Basket

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    MHSEAREAEA RRLLLQETLD AERTFLERNQ WGQFATPPSL AGEIMRYTID    50
    LHEETRINFL EPSCGSGSFF SALLRNLGDK KIEHAVGVEL DPRFSKAASD 100
    LWTGQGLRVI EGDFTSPSLV SGPVASLLVA NPPYVRHHHL GIDQKRDLVA 150
    RCADQLGIKP SGLSGLYLYF VLLSHRLLRA DAVSTWLIPS EFMDVNYGTA 200
    LKEYLATRVQ LVRIHQYDAA EVQFDDALVT SSVVVFRNSP PRPGHTAEFS 250
    FGGTLSEPKV THQIPSAALT PEAKWSRYVT GVMPADINLK QTGPKLSDFF 300
    KIRRGLATGS NAFFIIPRSE AERLGIKRNF LRPILPSPRK LKGDAITADA 350
    SGWPDIPEQL ALLDCPLPIE DLLLENPALA AYLSTADEKI RGGYLVSKRS 400
    PWYKQEQREP APILLTYMGR GKDDQHPLRF IRNDSDAVAT NMYLMLYPTA 450
    LLQRYLAGDP ERIKQVHKAL LAITAADLRG GGRVYGGGLH KMEPKELAAL 500
    PADGIATLDP VLREDISMVS VPPRKRTGRP QMPGPSASEV RAWARANGVC 550
    VPDRGRLRPE VWDAWRQAHA GEASPLNIDA GDQVALW 587
    Length:587
    Mass (Da):64,975
    Last modified:November 1, 1996 - v1
    Checksum:iB482F374397FF999
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01232 Genomic DNA. Translation: AAA81887.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01232 Genomic DNA. Translation: AAA81887.1 .

    3D structure databases

    ProteinModelPortali Q53609.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3491. M.SalI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR024412. Lsr2.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF11774. Lsr2. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    ProDomi PD026347. PD026347. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and sequence of the SalI restriction-modification system."
      Rodicio M.R., Quinton-Jager T., Moran L.S., Slatko B.E., Wilson G.G.
      Gene 151:167-172(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMTS1_STRAL
    AccessioniPrimary (citable) accession number: Q53609
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3