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Q53609

- MTS1_STRAL

UniProt

Q53609 - MTS1_STRAL

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Protein
Modification methylase SalI
Gene
salIM
Organism
Streptomyces albus G
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GTCGAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the SalI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3491. M.SalI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase SalI (EC:2.1.1.72)
Short name:
M.SalI
Alternative name(s):
Adenine-specific methyltransferase SalI
Gene namesi
Name:salIM
OrganismiStreptomyces albus G
Taxonomic identifieri1962 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Modification methylase SalI
PRO_0000087979Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ53609.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR024412. Lsr2.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF11774. Lsr2. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
ProDomiPD026347. PD026347. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53609-1 [UniParc]FASTAAdd to Basket

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MHSEAREAEA RRLLLQETLD AERTFLERNQ WGQFATPPSL AGEIMRYTID    50
LHEETRINFL EPSCGSGSFF SALLRNLGDK KIEHAVGVEL DPRFSKAASD 100
LWTGQGLRVI EGDFTSPSLV SGPVASLLVA NPPYVRHHHL GIDQKRDLVA 150
RCADQLGIKP SGLSGLYLYF VLLSHRLLRA DAVSTWLIPS EFMDVNYGTA 200
LKEYLATRVQ LVRIHQYDAA EVQFDDALVT SSVVVFRNSP PRPGHTAEFS 250
FGGTLSEPKV THQIPSAALT PEAKWSRYVT GVMPADINLK QTGPKLSDFF 300
KIRRGLATGS NAFFIIPRSE AERLGIKRNF LRPILPSPRK LKGDAITADA 350
SGWPDIPEQL ALLDCPLPIE DLLLENPALA AYLSTADEKI RGGYLVSKRS 400
PWYKQEQREP APILLTYMGR GKDDQHPLRF IRNDSDAVAT NMYLMLYPTA 450
LLQRYLAGDP ERIKQVHKAL LAITAADLRG GGRVYGGGLH KMEPKELAAL 500
PADGIATLDP VLREDISMVS VPPRKRTGRP QMPGPSASEV RAWARANGVC 550
VPDRGRLRPE VWDAWRQAHA GEASPLNIDA GDQVALW 587
Length:587
Mass (Da):64,975
Last modified:November 1, 1996 - v1
Checksum:iB482F374397FF999
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01232 Genomic DNA. Translation: AAA81887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01232 Genomic DNA. Translation: AAA81887.1 .

3D structure databases

ProteinModelPortali Q53609.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3491. M.SalI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002052. DNA_methylase_N6_adenine_CS.
IPR024412. Lsr2.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF11774. Lsr2. 1 hit.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
ProDomi PD026347. PD026347. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization and sequence of the SalI restriction-modification system."
    Rodicio M.R., Quinton-Jager T., Moran L.S., Slatko B.E., Wilson G.G.
    Gene 151:167-172(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTS1_STRAL
AccessioniPrimary (citable) accession number: Q53609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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