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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

hpd

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationNote: Binds 1 Fe cation per subunit.

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Iron1
Metal bindingi270Iron1
Metal bindingi349Iron1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.27. 5980.
SABIO-RKQ53586.
UniPathwayiUPA00139; UER00362.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:hpd
Ordered Locus Names:SAV_5149
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000884091 – 3814-hydroxyphenylpyruvate dioxygenaseAdd BLAST381

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi227882.SAV_5149.

Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 29Combined sources8
Helixi33 – 42Combined sources10
Beta strandi47 – 53Combined sources7
Helixi54 – 56Combined sources3
Beta strandi60 – 68Combined sources9
Beta strandi71 – 80Combined sources10
Helixi84 – 96Combined sources13
Beta strandi98 – 106Combined sources9
Helixi110 – 119Combined sources10
Beta strandi124 – 133Combined sources10
Beta strandi136 – 144Combined sources9
Beta strandi150 – 159Combined sources10
Beta strandi161 – 164Combined sources4
Beta strandi184 – 191Combined sources8
Helixi197 – 208Combined sources12
Helixi219 – 222Combined sources4
Turni223 – 226Combined sources4
Beta strandi227 – 234Combined sources8
Beta strandi240 – 247Combined sources8
Beta strandi250 – 252Combined sources3
Helixi255 – 263Combined sources9
Beta strandi267 – 274Combined sources8
Helixi278 – 287Combined sources10
Helixi297 – 299Combined sources3
Helixi303 – 307Combined sources5
Helixi314 – 320Combined sources7
Beta strandi323 – 326Combined sources4
Beta strandi331 – 337Combined sources7
Beta strandi340 – 344Combined sources5
Beta strandi347 – 355Combined sources9
Helixi363 – 376Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T47X-ray2.50A/B1-381[»]
ProteinModelPortaliQ53586.
SMRiQ53586.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53586.

Family & Domainsi

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Phylogenomic databases

eggNOGiENOG4105E6K. Bacteria.
COG3185. LUCA.
HOGENOMiHOG000188687.
KOiK00457.
OMAiAKQAAHY.
OrthoDBiPOG091H02GY.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 2 hits.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTTHHTPD TARQADPFPV KGMDAVVFAV GNAKQAAHYY STAFGMQLVA
60 70 80 90 100
YSGPENGSRE TASYVLTNGS ARFVLTSVIK PATPWGHFLA DHVAEHGDGV
110 120 130 140 150
VDLAIEVPDA RAAHAYAIEH GARSVAEPYE LKDEHGTVVL AAIATYGKTR
160 170 180 190 200
HTLVDRTGYD GPYLPGYVAA APIVEPPAHR TFQAIDHCVG NVELGRMNEW
210 220 230 240 250
VGFYNKVMGF TNMKEFVGDD IATEYSALMS KVVADGTLKV KFPINEPALA
260 270 280 290 300
KKKSQIDEYL EFYGGAGVQH IALNTGDIVE TVRTMRAAGV QFLDTPDSYY
310 320 330 340 350
DTLGEWVGDT RVPVDTLREL KILADRDEDG YLLQIFTKPV QDRPTVFFEI
360 370 380
IERHGSMGFG KGNFKALFEA IEREQEKRGN L
Length:381
Mass (Da):41,863
Last modified:May 9, 2003 - v2
Checksum:i4A3B3E7B646165D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40Missing in AAA50231 (PubMed:8071207).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11864 Genomic DNA. Translation: AAA50231.1.
AB070935 Genomic DNA. Translation: BAB69150.1.
BA000030 Genomic DNA. Translation: BAC72861.1.
RefSeqiWP_010986553.1. NZ_JZJK01000072.1.

Genome annotation databases

EnsemblBacteriaiBAC72861; BAC72861; SAVERM_5149.
KEGGisma:SAV_5149.
PATRICi23724242. VBIStrAve112782_5488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11864 Genomic DNA. Translation: AAA50231.1.
AB070935 Genomic DNA. Translation: BAB69150.1.
BA000030 Genomic DNA. Translation: BAC72861.1.
RefSeqiWP_010986553.1. NZ_JZJK01000072.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T47X-ray2.50A/B1-381[»]
ProteinModelPortaliQ53586.
SMRiQ53586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_5149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC72861; BAC72861; SAVERM_5149.
KEGGisma:SAV_5149.
PATRICi23724242. VBIStrAve112782_5488.

Phylogenomic databases

eggNOGiENOG4105E6K. Bacteria.
COG3185. LUCA.
HOGENOMiHOG000188687.
KOiK00457.
OMAiAKQAAHY.
OrthoDBiPOG091H02GY.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00362.
BRENDAi1.13.11.27. 5980.
SABIO-RKQ53586.

Miscellaneous databases

EvolutionaryTraceiQ53586.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 2 hits.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHPPD_STRAW
AccessioniPrimary (citable) accession number: Q53586
Secondary accession number(s): Q93HN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 9, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.