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Protein

Salicylate hydroxylase

Gene

nahG

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Salicylate + NADH + O2 = catechol + NAD+ + H2O + CO2.

Cofactori

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 4130FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. salicylate 1-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00082.

Names & Taxonomyi

Protein namesi
Recommended name:
Salicylate hydroxylase (EC:1.14.13.1)
Alternative name(s):
Salicylate 1-monooxygenase
Gene namesi
Name:nahG
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Salicylate hydroxylasePRO_0000096804Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ53552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
IPR017631. Salicylate_mOase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR03219. salicylate_mono. 1 hit.

Sequencei

Sequence statusi: Complete.

Q53552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDMNAKKPA LRVAIVGGGI SGLALALSLC KHSHLNVQLF EAAPAFGEVG
60 70 80 90 100
AGVSFGPNAV RAIVGLGLGQ AYFQVADRTP QPWEDIWFEW RRGSDASYLG
110 120 130 140 150
ATIAGVGQSS VHRADFLDAL VKHLPEGIAQ FRKRATQIEQ QGDELQVLFR
160 170 180 190 200
DGTEYRCDLL IGRDGIKSAL RSYVLEGQGQ DHLEPRFSGT CAYRGMVDSL
210 220 230 240 250
QLREAYRING IDEHLVDVPQ MYLGLYGHIL TFPVRKGRIV NVVAFTSDRS
260 270 280 290 300
QPEPTWPADA PWVREASQRE MLDAFAGWGD ARALLECIPA PTLWALHDLP
310 320 330 340 350
ELPGYVHGRV ALIGDAAHAM LPHQGAGAGQ GLEDAYFLAR LLGDSRTETG
360 370 380 390 400
NLPELLGAYD DLRRPHACRV QRTTVETGEL YELRDPIVGA DEQLVGEILA
410 420 430
TRFDWLWNHD LDADVAEARL RMGWEAHEQI ALRQG
Length:435
Mass (Da):47,914
Last modified:November 1, 1996 - v1
Checksum:i7E8017520726DD8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80995 Genomic DNA. Translation: AAB35960.1.
PIRiJC4590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80995 Genomic DNA. Translation: AAB35960.1.
PIRiJC4590.

3D structure databases

ProteinModelPortaliQ53552.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00082.

Family and domain databases

InterProiIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
IPR017631. Salicylate_mOase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR03219. salicylate_mono. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of salicylate hydroxylase gene and its 5'-flanking region of Pseudomonas putida KF715."
    Lee J., Oh J., Min K.R., Kim Y.
    Biochem. Biophys. Res. Commun. 218:544-548(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KF715.

Entry informationi

Entry nameiNHG2_PSEPU
AccessioniPrimary (citable) accession number: Q53552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.