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Q53479

- IDSA_METTM

UniProt

Q53479 - IDSA_METTM

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Protein
Short chain isoprenyl diphosphate synthase
Gene
idsA, MTBMA_c05390
Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Binds 3 magnesium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Isopentenyl diphosphate By similarity
Binding sitei47 – 471Isopentenyl diphosphate By similarity
Binding sitei76 – 761Isopentenyl diphosphate By similarity
Metal bindingi83 – 831Magnesium 1 By similarity
Metal bindingi83 – 831Magnesium 2 By similarity
Metal bindingi87 – 871Magnesium 1 By similarity
Metal bindingi87 – 871Magnesium 2 By similarity
Binding sitei92 – 921Allylic substrate By similarity
Binding sitei93 – 931Isopentenyl diphosphate By similarity
Binding sitei173 – 1731Isopentenyl By similarity
Binding sitei174 – 1741Allylic substrate By similarity
Binding sitei211 – 2111Allylic substrate By similarity
Metal bindingi214 – 2141Magnesium 3 By similarity
Binding sitei228 – 2281Allylic substrate By similarity
Binding sitei238 – 2381Allylic substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14627.
MMAR79929:GH5J-542-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Short chain isoprenyl diphosphate synthase (EC:2.5.1.-)
Gene namesi
Name:idsA
Ordered Locus Names:MTBMA_c05390
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 325324Short chain isoprenyl diphosphate synthase
PRO_0000123972Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ53479.

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.

Phylogenomic databases

HOGENOMiHOG000009101.
KOiK13787.
OMAiMLVNAIK.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53479-1 [UniParc]FASTAAdd to Basket

« Hide

MTEVLDILRK YSEVADKRIM ECISDITPDT LLKASEHLIT AGGKKIRPSL    50
ALLSCEAVGG NPEDAAGVAA AIELIHTFSL IHDDIMDDDE MRRGEPSVHV 100
IWGEPMAILA GDVLFSKAFE AVIRNGDSER VKDALAVVVD SCVKICEGQA 150
LDMGFEERLD VTEDEYMEMI YKKTAALIAA ATKAGAIMGG ASEREVEALE 200
DYGKFIGLAF QIHDDYLDVV SDEESLGKPV GSDIAEGKMT LMVVKALEEA 250
SEEDRERLIS ILGSGDEGSV AEAIEIFERY GATQYAHEVA LDYVRMAKER 300
LEILEDSDAR DALMRIADFV LEREH 325
Length:325
Mass (Da):35,636
Last modified:January 23, 2007 - v3
Checksum:iD28CAFF56EBE27E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75695 Genomic DNA. Translation: AAB32421.1.
CP001710 Genomic DNA. Translation: ADL58134.1.
RefSeqiYP_003849447.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL58134; ADL58134; MTBMA_c05390.
GeneIDi9704247.
KEGGimmg:MTBMA_c05390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75695 Genomic DNA. Translation: AAB32421.1 .
CP001710 Genomic DNA. Translation: ADL58134.1 .
RefSeqi YP_003849447.1. NC_014408.1.

3D structure databases

ProteinModelPortali Q53479.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL58134 ; ADL58134 ; MTBMA_c05390 .
GeneIDi 9704247.
KEGGi mmg:MTBMA_c05390.

Phylogenomic databases

HOGENOMi HOG000009101.
KOi K13787.
OMAi MLVNAIK.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14627.
MMAR79929:GH5J-542-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of idsA: the gene for the short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum."
    Chen A., Poulter C.D.
    Arch. Biochem. Biophys. 314:399-404(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Entry informationi

Entry nameiIDSA_METTM
AccessioniPrimary (citable) accession number: Q53479
Secondary accession number(s): D9PV86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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