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Q53479

- IDSA_METTM

UniProt

Q53479 - IDSA_METTM

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Protein

Short chain isoprenyl diphosphate synthase

Gene

idsA

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Binds 3 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Isopentenyl diphosphateBy similarity
Binding sitei47 – 471Isopentenyl diphosphateBy similarity
Binding sitei76 – 761Isopentenyl diphosphateBy similarity
Metal bindingi83 – 831Magnesium 1By similarity
Metal bindingi83 – 831Magnesium 2By similarity
Metal bindingi87 – 871Magnesium 1By similarity
Metal bindingi87 – 871Magnesium 2By similarity
Binding sitei92 – 921Allylic substrateBy similarity
Binding sitei93 – 931Isopentenyl diphosphateBy similarity
Binding sitei173 – 1731IsopentenylBy similarity
Binding sitei174 – 1741Allylic substrateBy similarity
Binding sitei211 – 2111Allylic substrateBy similarity
Metal bindingi214 – 2141Magnesium 3By similarity
Binding sitei228 – 2281Allylic substrateBy similarity
Binding sitei238 – 2381Allylic substrateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14627.
MMAR79929:GH5J-542-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Short chain isoprenyl diphosphate synthase (EC:2.5.1.-)
Gene namesi
Name:idsA
Ordered Locus Names:MTBMA_c05390
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 325324Short chain isoprenyl diphosphate synthasePRO_0000123972Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ53479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000009101.
KOiK13787.
OMAiMLVNAIK.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q53479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEVLDILRK YSEVADKRIM ECISDITPDT LLKASEHLIT AGGKKIRPSL
60 70 80 90 100
ALLSCEAVGG NPEDAAGVAA AIELIHTFSL IHDDIMDDDE MRRGEPSVHV
110 120 130 140 150
IWGEPMAILA GDVLFSKAFE AVIRNGDSER VKDALAVVVD SCVKICEGQA
160 170 180 190 200
LDMGFEERLD VTEDEYMEMI YKKTAALIAA ATKAGAIMGG ASEREVEALE
210 220 230 240 250
DYGKFIGLAF QIHDDYLDVV SDEESLGKPV GSDIAEGKMT LMVVKALEEA
260 270 280 290 300
SEEDRERLIS ILGSGDEGSV AEAIEIFERY GATQYAHEVA LDYVRMAKER
310 320
LEILEDSDAR DALMRIADFV LEREH
Length:325
Mass (Da):35,636
Last modified:January 23, 2007 - v3
Checksum:iD28CAFF56EBE27E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75695 Genomic DNA. Translation: AAB32421.1.
CP001710 Genomic DNA. Translation: ADL58134.1.
RefSeqiYP_003849447.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL58134; ADL58134; MTBMA_c05390.
GeneIDi9704247.
KEGGimmg:MTBMA_c05390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75695 Genomic DNA. Translation: AAB32421.1 .
CP001710 Genomic DNA. Translation: ADL58134.1 .
RefSeqi YP_003849447.1. NC_014408.1.

3D structure databases

ProteinModelPortali Q53479.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL58134 ; ADL58134 ; MTBMA_c05390 .
GeneIDi 9704247.
KEGGi mmg:MTBMA_c05390.

Phylogenomic databases

HOGENOMi HOG000009101.
KOi K13787.
OMAi MLVNAIK.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14627.
MMAR79929:GH5J-542-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of idsA: the gene for the short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum."
    Chen A., Poulter C.D.
    Arch. Biochem. Biophys. 314:399-404(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Entry informationi

Entry nameiIDSA_METTM
AccessioniPrimary (citable) accession number: Q53479
Secondary accession number(s): D9PV86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3