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Q53479

- IDSA_METTM

UniProt

Q53479 - IDSA_METTM

Protein

Short chain isoprenyl diphosphate synthase

Gene

idsA

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441Isopentenyl diphosphateBy similarity
    Binding sitei47 – 471Isopentenyl diphosphateBy similarity
    Binding sitei76 – 761Isopentenyl diphosphateBy similarity
    Metal bindingi83 – 831Magnesium 1By similarity
    Metal bindingi83 – 831Magnesium 2By similarity
    Metal bindingi87 – 871Magnesium 1By similarity
    Metal bindingi87 – 871Magnesium 2By similarity
    Binding sitei92 – 921Allylic substrateBy similarity
    Binding sitei93 – 931Isopentenyl diphosphateBy similarity
    Binding sitei173 – 1731IsopentenylBy similarity
    Binding sitei174 – 1741Allylic substrateBy similarity
    Binding sitei211 – 2111Allylic substrateBy similarity
    Metal bindingi214 – 2141Magnesium 3By similarity
    Binding sitei228 – 2281Allylic substrateBy similarity
    Binding sitei238 – 2381Allylic substrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14627.
    MMAR79929:GH5J-542-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short chain isoprenyl diphosphate synthase (EC:2.5.1.-)
    Gene namesi
    Name:idsA
    Ordered Locus Names:MTBMA_c05390
    OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri79929 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000000345: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 325324Short chain isoprenyl diphosphate synthasePRO_0000123972Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ53479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000009101.
    KOiK13787.
    OMAiMLVNAIK.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PANTHERiPTHR12001. PTHR12001. 1 hit.
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q53479-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEVLDILRK YSEVADKRIM ECISDITPDT LLKASEHLIT AGGKKIRPSL    50
    ALLSCEAVGG NPEDAAGVAA AIELIHTFSL IHDDIMDDDE MRRGEPSVHV 100
    IWGEPMAILA GDVLFSKAFE AVIRNGDSER VKDALAVVVD SCVKICEGQA 150
    LDMGFEERLD VTEDEYMEMI YKKTAALIAA ATKAGAIMGG ASEREVEALE 200
    DYGKFIGLAF QIHDDYLDVV SDEESLGKPV GSDIAEGKMT LMVVKALEEA 250
    SEEDRERLIS ILGSGDEGSV AEAIEIFERY GATQYAHEVA LDYVRMAKER 300
    LEILEDSDAR DALMRIADFV LEREH 325
    Length:325
    Mass (Da):35,636
    Last modified:January 23, 2007 - v3
    Checksum:iD28CAFF56EBE27E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75695 Genomic DNA. Translation: AAB32421.1.
    CP001710 Genomic DNA. Translation: ADL58134.1.
    RefSeqiYP_003849447.1. NC_014408.1.

    Genome annotation databases

    EnsemblBacteriaiADL58134; ADL58134; MTBMA_c05390.
    GeneIDi9704247.
    KEGGimmg:MTBMA_c05390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75695 Genomic DNA. Translation: AAB32421.1 .
    CP001710 Genomic DNA. Translation: ADL58134.1 .
    RefSeqi YP_003849447.1. NC_014408.1.

    3D structure databases

    ProteinModelPortali Q53479.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL58134 ; ADL58134 ; MTBMA_c05390 .
    GeneIDi 9704247.
    KEGGi mmg:MTBMA_c05390.

    Phylogenomic databases

    HOGENOMi HOG000009101.
    KOi K13787.
    OMAi MLVNAIK.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-14627.
    MMAR79929:GH5J-542-MONOMER.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    PANTHERi PTHR12001. PTHR12001. 1 hit.
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of idsA: the gene for the short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum."
      Chen A., Poulter C.D.
      Arch. Biochem. Biophys. 314:399-404(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
    2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
      Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
      J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

    Entry informationi

    Entry nameiIDSA_METTM
    AccessioniPrimary (citable) accession number: Q53479
    Secondary accession number(s): D9PV86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 72 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3