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Protein

Urea transporter

Gene

slc14a2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377Important for channel permeabilityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • urea transport Source: ZFIN

Keywordsi

Biological processTransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporterUniRule annotation
Gene namesi
Name:slc14a2Imported
ORF Names:zgc:136632Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-4833 slc14a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei99 – 124HelicalSequence analysisAdd BLAST26
Transmembranei130 – 148HelicalSequence analysisAdd BLAST19
Transmembranei155 – 174HelicalSequence analysisAdd BLAST20
Transmembranei180 – 203HelicalSequence analysisAdd BLAST24
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei319 – 341HelicalSequence analysisAdd BLAST23
Transmembranei348 – 365HelicalSequence analysisAdd BLAST18
Transmembranei371 – 390HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000051914

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068116

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEWG Eukaryota
COG4413 LUCA
GeneTreeiENSGT00390000018729
HOGENOMiHOG000065705
HOVERGENiHBG000540
KOiK08716
OMAiWGYNCVL
OrthoDBiEOG091G095L

Family and domain databases

Gene3Di1.10.3430.101 hit
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR004937 Urea_transporter
PANTHERiPTHR10464 PTHR10464, 1 hit
PfamiView protein in Pfam
PF03253 UT, 1 hit
PIRSFiPIRSF016502 Urea_transporter, 1 hit

Sequencei

Sequence statusi: Complete.

Q533H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTHLTKKS DPLNVTHLCK TSTSTQYSSA QNTKELQPLM ANPVHKITDE
60 70 80 90 100
KKQQGLEKIN SGQRFKANLI KWVSFISGDM AAFGEWMKGQ FILLQIMDWV
110 120 130 140 150
LRGAAQVMFV NNPLSGLIIF AGLILQNRWW ALNGFVGTVF ATISALILCQ
160 170 180 190 200
NRGAIAAGLY GYNGILVGLL MAVFSNAGDW YWWLLLPNIF MSMACPIVSS
210 220 230 240 250
ALASINSRWD LPVFTLPFNI LVCLHMVATG HYNQYFPQIL IQPTTSMSNL
260 270 280 290 300
TWSELDYAQL FRSIPVGIGQ VYGCDNAWTG GIFMIALFIS SPITFAHATI
310 320 330 340 350
GSAVGMVSGL ALAAPFKNIY MGLWGYNCVL ACIAIGGMFY ALTWQTHLLA
360 370 380 390 400
VACAFFCAYL GSAIGNVMSN FGLPACTWPF CLSALTFLLI TTETKFIHKL
410 420 430 440 450
PLAKVAYPEQ NLRYYWKMKK EEKTQKGIQA KDTESQLEKE QISISMEKKD
460
LDICTVDVQQ EENTL
Length:465
Mass (Da):51,603
Last modified:May 24, 2005 - v1
Checksum:iAC15C3D9D47B0FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927249 Genomic DNA No translation available.
CABZ01058515 Genomic DNA No translation available.
FP016029 Genomic DNA No translation available.
BC115203 mRNA Translation: AAI15204.1
AY788989 mRNA Translation: AAX16119.1
RefSeqiNP_001018355.1, NM_001020519.1
UniGeneiDr.80625

Genome annotation databases

EnsembliENSDART00000162256; ENSDARP00000135209; ENSDARG00000051914
GeneIDi326634
KEGGidre:326634

Similar proteinsi

Entry informationi

Entry nameiQ533H0_DANRE
AccessioniPrimary (citable) accession number: Q533H0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported