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Protein
Submitted name:

Facilitated urea transporter

Gene

slc14a2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • urea transport Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Submitted name:
Facilitated urea transporterImported
Submitted name:
Uncharacterized proteinImported
Submitted name:
Zgc:136632Imported
Gene namesi
Name:slc14a2Imported
ORF Names:zgc:136632Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-4833. slc14a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei99 – 12426HelicalSequence analysisAdd
BLAST
Transmembranei130 – 14819HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17420HelicalSequence analysisAdd
BLAST
Transmembranei180 – 20324HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei319 – 34123HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36518HelicalSequence analysisAdd
BLAST
Transmembranei371 – 39020HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068116.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
KOiK08716.
OMAiWGYNCVL.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q533H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTHLTKKS DPLNVTHLCK TSTSTQYSSA QNTKELQPLM ANPVHKITDE
60 70 80 90 100
KKQQGLEKIN SGQRFKANLI KWVSFISGDM AAFGEWMKGQ FILLQIMDWV
110 120 130 140 150
LRGAAQVMFV NNPLSGLIIF AGLILQNRWW ALNGFVGTVF ATISALILCQ
160 170 180 190 200
NRGAIAAGLY GYNGILVGLL MAVFSNAGDW YWWLLLPNIF MSMACPIVSS
210 220 230 240 250
ALASINSRWD LPVFTLPFNI LVCLHMVATG HYNQYFPQIL IQPTTSMSNL
260 270 280 290 300
TWSELDYAQL FRSIPVGIGQ VYGCDNAWTG GIFMIALFIS SPITFAHATI
310 320 330 340 350
GSAVGMVSGL ALAAPFKNIY MGLWGYNCVL ACIAIGGMFY ALTWQTHLLA
360 370 380 390 400
VACAFFCAYL GSAIGNVMSN FGLPACTWPF CLSALTFLLI TTETKFIHKL
410 420 430 440 450
PLAKVAYPEQ NLRYYWKMKK EEKTQKGIQA KDTESQLEKE QISISMEKKD
460
LDICTVDVQQ EENTL
Length:465
Mass (Da):51,603
Last modified:May 24, 2005 - v1
Checksum:iAC15C3D9D47B0FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927249 Genomic DNA. No translation available.
CABZ01058515 Genomic DNA. No translation available.
FP016029 Genomic DNA. No translation available.
BC115203 mRNA. Translation: AAI15204.1.
AY788989 mRNA. Translation: AAX16119.1.
RefSeqiNP_001018355.1. NM_001020519.1.
UniGeneiDr.80625.

Genome annotation databases

EnsembliENSDART00000162256; ENSDARP00000135209; ENSDARG00000051914.
GeneIDi326634.
KEGGidre:326634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927249 Genomic DNA. No translation available.
CABZ01058515 Genomic DNA. No translation available.
FP016029 Genomic DNA. No translation available.
BC115203 mRNA. Translation: AAI15204.1.
AY788989 mRNA. Translation: AAX16119.1.
RefSeqiNP_001018355.1. NM_001020519.1.
UniGeneiDr.80625.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000162256; ENSDARP00000135209; ENSDARG00000051914.
GeneIDi326634.
KEGGidre:326634.

Organism-specific databases

CTDi8170.
ZFINiZDB-GENE-030131-4833. slc14a2.

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
KOiK08716.
OMAiWGYNCVL.

Enzyme and pathway databases

ReactomeiR-DRE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

NextBioi20809665.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel cDNA encoding a zebrafish facilitated urea transporter (zfUT-A)."
    Potter E.A., Hurlstone A.F., Smith C.P.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TuebingenImported.
    Tissue: Whole bodyImported.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  4. Ensembl
    Submitted (NOV-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ533H0_DANRE
AccessioniPrimary (citable) accession number: Q533H0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.