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Protein

Urea transporter

Gene

slc14a2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377Important for channel permeabilityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • urea transport Source: ZFIN

Keywordsi

Biological processTransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporterUniRule annotation
Gene namesi
Name:slc14a2Imported
ORF Names:zgc:136632Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-4833. slc14a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei99 – 124HelicalSequence analysisAdd BLAST26
Transmembranei130 – 148HelicalSequence analysisAdd BLAST19
Transmembranei155 – 174HelicalSequence analysisAdd BLAST20
Transmembranei180 – 203HelicalSequence analysisAdd BLAST24
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei319 – 341HelicalSequence analysisAdd BLAST23
Transmembranei348 – 365HelicalSequence analysisAdd BLAST18
Transmembranei371 – 390HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000051914.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068116.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEWG. Eukaryota.
COG4413. LUCA.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000065705.
HOVERGENiHBG000540.
KOiK08716.
OMAiWGYNCVL.
OrthoDBiEOG091G095L.

Family and domain databases

InterProiView protein in InterPro
IPR004937. Urea_transporter.
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiView protein in Pfam
PF03253. UT. 1 hit.
PIRSFiPIRSF016502. Urea_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q533H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTHLTKKS DPLNVTHLCK TSTSTQYSSA QNTKELQPLM ANPVHKITDE
60 70 80 90 100
KKQQGLEKIN SGQRFKANLI KWVSFISGDM AAFGEWMKGQ FILLQIMDWV
110 120 130 140 150
LRGAAQVMFV NNPLSGLIIF AGLILQNRWW ALNGFVGTVF ATISALILCQ
160 170 180 190 200
NRGAIAAGLY GYNGILVGLL MAVFSNAGDW YWWLLLPNIF MSMACPIVSS
210 220 230 240 250
ALASINSRWD LPVFTLPFNI LVCLHMVATG HYNQYFPQIL IQPTTSMSNL
260 270 280 290 300
TWSELDYAQL FRSIPVGIGQ VYGCDNAWTG GIFMIALFIS SPITFAHATI
310 320 330 340 350
GSAVGMVSGL ALAAPFKNIY MGLWGYNCVL ACIAIGGMFY ALTWQTHLLA
360 370 380 390 400
VACAFFCAYL GSAIGNVMSN FGLPACTWPF CLSALTFLLI TTETKFIHKL
410 420 430 440 450
PLAKVAYPEQ NLRYYWKMKK EEKTQKGIQA KDTESQLEKE QISISMEKKD
460
LDICTVDVQQ EENTL
Length:465
Mass (Da):51,603
Last modified:May 24, 2005 - v1
Checksum:iAC15C3D9D47B0FB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927249 Genomic DNA. No translation available.
CABZ01058515 Genomic DNA. No translation available.
FP016029 Genomic DNA. No translation available.
BC115203 mRNA. Translation: AAI15204.1.
AY788989 mRNA. Translation: AAX16119.1.
RefSeqiNP_001018355.1. NM_001020519.1.
UniGeneiDr.80625.

Genome annotation databases

EnsembliENSDART00000162256; ENSDARP00000135209; ENSDARG00000051914.
GeneIDi326634.
KEGGidre:326634.

Similar proteinsi

Entry informationi

Entry nameiQ533H0_DANRE
AccessioniPrimary (citable) accession number: Q533H0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported