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Protein

Photosynthetic apparatus regulatory protein RegA

Gene

regA

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system RegB/RegA. Involved in transactivating anaerobic expression of the photosynthetic apparatus. It is a transcriptional regulator that is responsible for activating expression of the puf, puh, and puc operons in response to a decrease in oxygen tension.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Photosynthetic apparatus regulatory protein RegA
Alternative name(s):
Response regulator PrrA
Gene namesi
Name:regA
Synonyms:prrA
Ordered Locus Names:RHOS4_00930
ORF Names:RSP_1518
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Photosynthetic apparatus regulatory protein RegAPRO_0000081216Add
BLAST

Post-translational modificationi

Phosphorylated by RegB.Curated

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiQ53228. 2 interactions.
MINTiMINT-2516416.
STRINGi272943.RSP_1518.

Structurei

Secondary structure

1
184
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi137 – 1393Combined sources
Helixi141 – 15515Combined sources
Helixi160 – 1678Combined sources
Helixi171 – 1799Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UMQNMR-A125-184[»]
ProteinModelPortaliQ53228.
SMRiQ53228. Positions 125-184.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ53228.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 128115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UYB. Bacteria.
COG4567. LUCA.
HOGENOMiHOG000034817.
KOiK15012.
OMAiRGHAVAW.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ53228.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q53228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDLVFELG ADRSLLLVDD DEPFLKRLAK AMEKRGFVLE TAQSVAEGKA
60 70 80 90 100
IAQARPPAYA VVDLRLEDGN GLDVVEVLRE RRPDCRIVVL TGYGAIATAV
110 120 130 140 150
AAVKIGATDY LSKPADANEV THALLAKGES LPPPPENPMS ADRVRWEHIQ
160 170 180
RIYEMCDRNV SETARRLNMH RRTLQRILAK RSPR
Length:184
Mass (Da):20,484
Last modified:July 11, 2001 - v2
Checksum:iD73447E037F1285B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76559 Genomic DNA. Translation: CAA54059.2.
L25895 Unassigned DNA. Translation: AAA16649.1.
CP000143 Genomic DNA. Translation: ABA77661.1.
PIRiA36862.
S41451.
RefSeqiWP_002722225.1. NZ_AKVW01000001.1.
YP_351562.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA77661; ABA77661; RSP_1518.
GeneIDi3718682.
KEGGirsp:RSP_1518.
PATRICi23149974. VBIRhoSph57909_0391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76559 Genomic DNA. Translation: CAA54059.2.
L25895 Unassigned DNA. Translation: AAA16649.1.
CP000143 Genomic DNA. Translation: ABA77661.1.
PIRiA36862.
S41451.
RefSeqiWP_002722225.1. NZ_AKVW01000001.1.
YP_351562.1. NC_007493.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UMQNMR-A125-184[»]
ProteinModelPortaliQ53228.
SMRiQ53228. Positions 125-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ53228. 2 interactions.
MINTiMINT-2516416.
STRINGi272943.RSP_1518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA77661; ABA77661; RSP_1518.
GeneIDi3718682.
KEGGirsp:RSP_1518.
PATRICi23149974. VBIRhoSph57909_0391.

Phylogenomic databases

eggNOGiENOG4108UYB. Bacteria.
COG4567. LUCA.
HOGENOMiHOG000034817.
KOiK15012.
OMAiRGHAVAW.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ53228.

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-102-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ53228.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR009057. Homeodomain-like.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and nucleotide sequence of regA, a putative response regulator gene of Rhodobacter sphaeroides."
    Phillips-Jones M.K., Hunter C.N.
    FEMS Microbiol. Lett. 116:269-275(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Phillips-Jones M.K.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 98; 180-181 AND 183.
  3. "prrA, a putative response regulator involved in oxygen regulation of photosynthesis gene expression in Rhodobacter sphaeroides."
    Eraso J.M., Kaplan S.
    J. Bacteriol. 176:32-43(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiREGA_RHOS4
AccessioniPrimary (citable) accession number: Q53228
Secondary accession number(s): Q3J6C3, Q53227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: November 11, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.