ID   FIXC_SINFN              Reviewed;         435 AA.
AC   Q53208;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Protein FixC;
GN   Name=fixC; OrderedLocusNames=NGR_a01240; ORFNames=y4uP;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8796346; DOI=10.1101/gr.6.7.590;
RA   Freiberg C., Perret X., Broughton W.J., Rosenthal A.;
RT   "Sequencing the 500-kb GC-rich symbiotic replicon of Rhizobium sp. NGR234
RT   using dye terminators and a thermostable 'sequenase': a beginning.";
RL   Genome Res. 6:590-600(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Could be required for the formation of a functional
CC       nitrogenase Fe protein. Probably accepts electrons from FixA/FixB and
CC       reduces a quinone.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the ETF-QO/FixC family. {ECO:0000305}.
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DR   EMBL; Z68203; CAA92415.1; -; Genomic_DNA.
DR   EMBL; U00090; AAB91888.1; -; Genomic_DNA.
DR   RefSeq; NP_444101.1; NC_000914.2.
DR   RefSeq; WP_010875162.1; NC_000914.2.
DR   AlphaFoldDB; Q53208; -.
DR   SMR; Q53208; -.
DR   KEGG; rhi:NGR_a01240; -.
DR   PATRIC; fig|394.7.peg.108; -.
DR   eggNOG; COG0644; Bacteria.
DR   HOGENOM; CLU_050977_0_0_5; -.
DR   OrthoDB; 417034at2; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR039651; FixC-like.
DR   PANTHER; PTHR43624; ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED; 1.
DR   PANTHER; PTHR43624:SF2; ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Nitrogen fixation; Oxidoreductase; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..435
FT                   /note="Protein FixC"
FT                   /id="PRO_0000200689"
FT   BINDING         8..22
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   435 AA;  47536 MW;  5C4113C66F84BA61 CRC64;
     MTEERFDAIV VGAGMSGNAA AYTMASRGLK VLQLERGEYP GSKNVQGAIL YANMLETIIP
     DFRDDAPLER HLVEQRFWVT DDTSHTGMHY RSDDFNEPAP NRYTIIRAQF DKWFSRKVRA
     AGAIVLCETT VTELALDAAG KVIGVHTDRA GGVIHADVVV LAEGVNGLLG TRARFRKVPK
     PEAVALAVKE MHFLPEEVIN ERFGLTGDQG CVIEAAGTIS RGMAGLGFLY TNKESISLGI
     GCLVSHFAAT LESPYALLDA FKNHPSIRPL LAGSEIKEYA AHLIPEGGFK AIPQLFGDGW
     VVVGDAAQLN NAVHREGSNL AMTSGRIAGE AIAAIKSRKH PMTSDNLSLY KAMLDKSFVL
     KDLRKYKDMP ALLHTNSHNF FTTYPQLMSQ AAQNFVRVDG TPKIEKERAT TAALIKARSR
     WGLVSDAVRL ALAWR
//