ID   Q52WX2_HUMAN   PRELIMINARY;   PRT;   424 AA.
AC   Q52WX2;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   07-FEB-2006, entry version 9.
DE   SH3-binding kinase.
GN   Name=SBK1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Wang P.Z., Wang F., Wang X., Wu J.;
RT   "Cloning of three novel human kinases:PDPK2, CDKL4, SBK.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serine/threonine protein kinase probably involved in the
CC       cytoplasm to vacuole transport (Cvt) and in autophagy, where it
CC       may be required for the formation of autophagosomes (By
CC       similarity).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY874862; AAX59898.1; -; mRNA.
DR   HGNC; HGNC:17699; SBK1.
DR   GO; GO:0005524; F:ATP binding; IEA.
DR   GO; GO:0000166; F:nucleotide binding; IEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA.
DR   GO; GO:0016740; F:transferase activity; IEA.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
KW   ATP-binding; Autophagy; Kinase; Nucleotide-binding; Protein transport;
KW   Serine/threonine-protein kinase; Transferase; Transport.
SQ   SEQUENCE   424 AA;  46252 MW;  2E07FFDA5693311F CRC64;
     MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG
     KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET
     EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV
     LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG
     VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
     ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG
     SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI
     EICV
//