ID   SBK1_HUMAN              Reviewed;         424 AA.
AC   Q52WX2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-MAR-2009, entry version 38.
DE   RecName: Full=Serine/threonine-protein kinase SBK1;
DE            EC=2.7.11.1;
DE   AltName: Full=SH3-binding kinase 1;
GN   Name=SBK1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang P.Z., Wang X., Wang F., Wu J.;
RT   "Cloning of human SBK1 cDNA and screening of its interaction
RT   proteins.";
RL   Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 22:313-321(2006).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-63 AND TYR-64, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Epithelium;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [3]
RP   VARIANTS [LARGE SCALE ANALYSIS] GLU-92; THR-250 AND SER-261.
RX   PubMed=17344846; DOI=10.1038/nature05610;
RA   Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C.,
RA   Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S.,
RA   O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S.,
RA   Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E.,
RA   Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J.,
RA   Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K.,
RA   Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T.,
RA   West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P.,
RA   Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E.,
RA   DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E.,
RA   Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T.,
RA   Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
RT   "Patterns of somatic mutation in human cancer genomes.";
RL   Nature 446:153-158(2007).
CC   -!- FUNCTION: May be involved in signal-transduction pathways related
CC       to the control of brain development (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC       protein kinase family.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AY874862; AAX59898.1; -; mRNA.
DR   IPI; IPI00399180; -.
DR   RefSeq; NP_001019572.1; -.
DR   UniGene; Hs.97837; -.
DR   PRIDE; Q52WX2; -.
DR   Ensembl; ENSG00000188322; Homo sapiens.
DR   GeneID; 388228; -.
DR   KEGG; hsa:388228; -.
DR   GeneCards; GC16P028211; -.
DR   HGNC; HGNC:17699; SBK1.
DR   PharmGKB; PA134887617; -.
DR   HOGENOM; Q52WX2; -.
DR   HOVERGEN; Q52WX2; -.
DR   BRENDA; 2.7.11.1; 247.
DR   NextBio; 101893; -.
DR   ArrayExpress; Q52WX2; -.
DR   Bgee; Q52WX2; -.
DR   CleanEx; HS_SBK1; -.
DR   GermOnline; ENSG00000188322; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR016234; Ser/Thr_prot_kinase_Sbk1.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   PIRSF; PIRSF000566; Ser/Thr_PK_Sbk1; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Polymorphism; Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    424       Serine/threonine-protein kinase SBK1.
FT                                /FTId=PRO_0000238451.
FT   DOMAIN       53    318       Protein kinase.
FT   NP_BIND      59     67       ATP (By similarity).
FT   COMPBIAS    332    400       Pro-rich.
FT   ACT_SITE    174    174       Proton acceptor (By similarity).
FT   BINDING      82     82       ATP (By similarity).
FT   MOD_RES      63     63       Phosphothreonine.
FT   MOD_RES      64     64       Phosphotyrosine.
FT   VARIANT      12     12       R -> H (in dbSNP:rs35448675).
FT                                /FTId=VAR_051665.
FT   VARIANT      92     92       K -> E (in an ovarian mucinous carcinoma
FT                                sample; somatic mutation).
FT                                /FTId=VAR_041068.
FT   VARIANT     250    250       N -> T.
FT                                /FTId=VAR_041069.
FT   VARIANT     261    261       A -> S.
FT                                /FTId=VAR_041070.
SQ   SEQUENCE   424 AA;  46252 MW;  2E07FFDA5693311F CRC64;
     MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG
     KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET
     EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV
     LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG
     VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
     ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG
     SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI
     EICV
//