ID   SBK1_HUMAN     STANDARD;      PRT;   424 AA.
AC   Q52WX2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   05-SEP-2006, entry version 15.
DE   Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase
DE   1).
GN   Name=SBK1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang P.Z., Wang X., Wang F., Wu J.;
RT   "Cloning of human SBK1 cDNA and screening of its interaction
RT   proteins.";
RL   Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 22:313-321(2006).
CC   -!- FUNCTION: May be involved in signal-transduction pathways related
CC       to the control of brain development (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AY874862; AAX59898.1; -; mRNA.
DR   UniGene; Hs.97837; -.
DR   HGNC; HGNC:17699; SBK1.
DR   ArrayExpress; Q52WX2; -.
DR   InterPro; IPR011009; Kinase_like.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
KW   ATP-binding; Kinase; Nucleotide-binding;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    424       Serine/threonine-protein kinase SBK1.
FT                                /FTId=PRO_0000238451.
FT   DOMAIN       53    318       Protein kinase.
FT   NP_BIND      59     67       ATP (By similarity).
FT   COMPBIAS    332    400       Pro-rich.
FT   ACT_SITE    174    174       Proton acceptor (By similarity).
FT   BINDING      82     82       ATP (By similarity).
SQ   SEQUENCE   424 AA;  46252 MW;  2E07FFDA5693311F CRC64;
     MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG
     KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET
     EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV
     LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG
     VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
     ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG
     SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI
     EICV
//