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Protein

Serine/threonine-protein kinase SBK1

Gene

SBK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in signal-transduction pathways related to the control of brain development.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821ATPPROSITE-ProRule annotation
Active sitei174 – 1741Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 679ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ52WX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)
Alternative name(s):
SH3-binding kinase 1
Gene namesi
Name:SBK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17699. SBK1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887617.

Chemistry

ChEMBLiCHEMBL1163129.
GuidetoPHARMACOLOGYi2193.

Polymorphism and mutation databases

BioMutaiSBK1.
DMDMi74762155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Serine/threonine-protein kinase SBK1PRO_0000238451Add
BLAST

Proteomic databases

PaxDbiQ52WX2.
PRIDEiQ52WX2.

PTM databases

iPTMnetiQ52WX2.
PhosphoSiteiQ52WX2.

Expressioni

Gene expression databases

BgeeiQ52WX2.
CleanExiHS_SBK1.
GenevisibleiQ52WX2. HS.

Interactioni

Protein-protein interaction databases

BioGridi132609. 6 interactions.
STRINGi9606.ENSP00000343248.

Chemistry

BindingDBiQ52WX2.

Structurei

3D structure databases

ProteinModelPortaliQ52WX2.
SMRiQ52WX2. Positions 52-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 318266Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi332 – 40069Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiQ52WX2.
KOiK08858.
OMAiPLRREKM.
OrthoDBiEOG7SBNPJ.
PhylomeDBiQ52WX2.
TreeFamiTF326736.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR016234. Ser/Thr_kinase_Sbk1.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000566. Ser/Thr_PK_Sbk1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52WX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EDCYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHGRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP
360 370 380 390 400
LKRTVLTESG SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP
410 420
GRTDGRADKS KGQVVLATAI EICV
Length:424
Mass (Da):46,252
Last modified:May 24, 2005 - v1
Checksum:i2E07FFDA5693311F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121R → H.
Corresponds to variant rs35448675 [ dbSNP | Ensembl ].
VAR_051665
Natural varianti92 – 921K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_041068
Natural varianti250 – 2501N → T.1 Publication
Corresponds to variant rs56072383 [ dbSNP | Ensembl ].
VAR_041069
Natural varianti261 – 2611A → S.1 Publication
VAR_041070

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY874862 mRNA. Translation: AAX59898.1.
CCDSiCCDS32416.1.
RefSeqiNP_001019572.1. NM_001024401.2.
UniGeneiHs.97837.

Genome annotation databases

EnsembliENST00000341901; ENSP00000343248; ENSG00000188322.
GeneIDi388228.
KEGGihsa:388228.
UCSCiuc002dpd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY874862 mRNA. Translation: AAX59898.1.
CCDSiCCDS32416.1.
RefSeqiNP_001019572.1. NM_001024401.2.
UniGeneiHs.97837.

3D structure databases

ProteinModelPortaliQ52WX2.
SMRiQ52WX2. Positions 52-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132609. 6 interactions.
STRINGi9606.ENSP00000343248.

Chemistry

BindingDBiQ52WX2.
ChEMBLiCHEMBL1163129.
GuidetoPHARMACOLOGYi2193.

PTM databases

iPTMnetiQ52WX2.
PhosphoSiteiQ52WX2.

Polymorphism and mutation databases

BioMutaiSBK1.
DMDMi74762155.

Proteomic databases

PaxDbiQ52WX2.
PRIDEiQ52WX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341901; ENSP00000343248; ENSG00000188322.
GeneIDi388228.
KEGGihsa:388228.
UCSCiuc002dpd.3. human.

Organism-specific databases

CTDi388228.
GeneCardsiSBK1.
HGNCiHGNC:17699. SBK1.
neXtProtiNX_Q52WX2.
PharmGKBiPA134887617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiQ52WX2.
KOiK08858.
OMAiPLRREKM.
OrthoDBiEOG7SBNPJ.
PhylomeDBiQ52WX2.
TreeFamiTF326736.

Enzyme and pathway databases

SignaLinkiQ52WX2.

Miscellaneous databases

ChiTaRSiSBK1. human.
GenomeRNAii388228.
PROiQ52WX2.

Gene expression databases

BgeeiQ52WX2.
CleanExiHS_SBK1.
GenevisibleiQ52WX2. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR016234. Ser/Thr_kinase_Sbk1.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000566. Ser/Thr_PK_Sbk1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human SBK1 cDNA and screening of its interaction proteins."
    Wang P.Z., Wang X., Wang F., Wu J.
    Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao 22:313-321(2006)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-92; THR-250 AND SER-261.

Entry informationi

Entry nameiSBK1_HUMAN
AccessioniPrimary (citable) accession number: Q52WX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 24, 2005
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.