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Q52V40 (Q52V40_BRAFL) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase receptor RuleBase RU000312
EC=2.7.10.1 RuleBase RU000312
Gene names
Name:AmphiTrk EMBL AAX94284.1
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) EMBL AAX94284.1
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Cephalochordata › Branchiostomidae › Branchiostoma

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. RuleBase RU000312 SAAS SAAS008266

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. RuleBase RU000312

Contains 1 protein kinase domain. SAAS SAAS008266

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential EMBL AAX94284.1
Chain26 – 797772 Potential EMBL AAX94284.1
PRO_5000095021

Sequences

Sequence LengthMass (Da)Tools
Q52V40 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: BFEBA188ABAF5476

FASTA79789,799
        10         20         30         40         50         60 
MASRSGSFHL LVLACCCWLT AGGALRCPDD CTCREAKGEV ECERPNTLRA IPGPDDLNDI 

        70         80         90        100        110        120 
DKVKELYISG QQGLTRLTRE QLGHYKGLIK LVIKNSNLST IEDGAFKNNS NLTMIDLRNN 

       130        140        150        160        170        180 
KLSVLQWTLF SDLRLTELLL SDNPLACNCS SKWIQLWQSQ SRASFHTEKI SCITTTDETV 

       190        200        210        220        230        240 
DIRDLQLDSS CRLPTARVLT GEVTINKTQD VVVSCEASGS PAPTAEWNTA ELRSKFSLVI 

       250        260        270        280        290        300 
EELGRRQVLT IHNASEDDNG NWTCIAKNMV GIARANLVLK INAPPRILSL EYKVLFHKSI 

       310        320        330        340        350        360 
CFTVHGYPLP TLTWYKGRAL FTARNHMYVS MENSKVTPYE TSGCLKFEVP SHVDNGNYTL 

       370        380        390        400        410        420 
VATNTYGQTS RSLVVTFMKL PPVRTTNYTI RAPPNSSSHG TPGPTTDDNV PENQTTTYTR 

       430        440        450        460        470        480 
IETYIAVAVS SVVFIVVAIV LYCMRSRKIS RRECNINGSA APLQRSTSES NGEVVSRDSL 

       490        500        510        520        530        540 
RLSRLHVVEN PNYFRDSKEL VIRHIQRDTI HFVGELGEGA FGRVYLGKCE KLKPDEDASL 

       550        560        570        580        590        600 
VAVKTLKEMS VEDARKDFDR EAELLTNMQH ENIVKFYGVC TEGEPWLMIF EYMENGDLNN 

       610        620        630        640        650        660 
YLRSHGPDAA FLIKNPATHK ELSIVELLQI SVQVASGVEY MASQHFVHRD LATRNCLVGD 

       670        680        690        700        710        720 
KLVVKIGDFG MSRDIYSTDY YRVGGHTMLP VRWMPPESVL YRKFTIESDI WSFGVVLWEI 

       730        740        750        760        770        780 
FTFGKQPWYE LANHEVIECI TSGRLLGCPR GCPRNVRALM LGCWKKTPAQ RTNIQDIHKK 

       790 
LKEMLENRHQ VQVDIVA

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References

[1]"The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells."
Benito-Gutierrez E., Nake C., Llovera M., Comella J.X., Garcia-Fernandez J.
Development 132:2191-2202(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY902361 mRNA. Translation: AAX94284.1.

3D structure databases

ProteinModelPortalQ52V40.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG056735.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR01939. NTKRECEPTOR.
PR00109. TYRKINASE.
SMARTSM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ52V40_BRAFL
AccessionPrimary (citable) accession number: Q52V40
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 6, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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