ID   Q52T95_STAAU            Unreviewed;       218 AA.
AC   Q52T95;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   02-MAY-2006, sequence version 2.
DT   13-SEP-2023, entry version 73.
DE   SubName: Full=Enterotoxin type I {ECO:0000313|EMBL:AAX84816.2};
DE   Flags: Fragment;
OS   Staphylococcus aureus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:AAX84816.2};
RN   [1] {ECO:0007829|PDB:2G9H}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
RX   PubMed=16829512; DOI=10.1074/jbc.M603969200;
RA   Fernandez M.M., Guan R., Swaminathan C.P., Malchiodi E.L., Mariuzza R.A.;
RT   "Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a
RT   human major histocompatibility complex class II molecule.";
RL   J. Biol. Chem. 281:25356-25364(2006).
RN   [2] {ECO:0000313|EMBL:AAX84816.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fc30 {ECO:0000313|EMBL:AAX84810.2}, and Fc35
RC   {ECO:0000313|EMBL:AAX84816.2};
RX   PubMed=16023209; DOI=10.1016/j.molimm.2005.06.029;
RA   Fernandez M.M., De Marzi M.C., Berguer P., Burzyn D., Langley R.J.,
RA   Piazzon I., Mariuzza R.A., Malchiodi E.L.;
RT   "Binding of natural variants of staphylococcal superantigens SEG and SEI to
RT   TCR and MHC class II molecule.";
RL   Mol. Immunol. 43:927-938(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000256|ARBA:ARBA00008401}.
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DR   EMBL; AY961381; AAX84810.2; -; Genomic_DNA.
DR   EMBL; AY961387; AAX84816.2; -; Genomic_DNA.
DR   PDB; 2G9H; X-ray; 2.00 A; D=1-218.
DR   PDBsum; 2G9H; -.
DR   AlphaFoldDB; Q52T95; -.
DR   SMR; Q52T95; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.110; -; 1.
DR   Gene3D; 3.10.20.120; -; 1.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; Bacterial enterotoxins; 1.
DR   SUPFAM; SSF54334; Superantigen toxins, C-terminal domain; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2G9H};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Metal-binding {ECO:0007829|PDB:2G9H};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Superantigen {ECO:0000256|ARBA:ARBA00022633};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656}; Zinc {ECO:0007829|PDB:2G9H}.
FT   DOMAIN          31..83
FT                   /note="Staphylococcal/Streptococcal toxin OB-fold"
FT                   /evidence="ECO:0000259|Pfam:PF01123"
FT   DOMAIN          94..213
FT                   /note="Staphylococcal/Streptococcal toxin beta-grasp"
FT                   /evidence="ECO:0000259|Pfam:PF02876"
FT   BINDING         169
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:2G9H"
FT   BINDING         207
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:2G9H"
FT   BINDING         209
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:2G9H"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAX84816.2"
FT   NON_TER         218
FT                   /evidence="ECO:0000313|EMBL:AAX84816.2"
SQ   SEQUENCE   218 AA;  24927 MW;  72874C10B8717038 CRC64;
     QGDIGVGNLR NFYTKHDYID LKGLIDKNLP SANQLEFSTG INDLISESNN WDEISKFKGK
     KLDIFGIDYN GPCKSKYMYG GATLSGQYLN SARKIPINLW VNGKHKTIST DKISTNKKLV
     TAQEIDVKLR RYLQEEYNIY GHNSTGKGKE YGYKSKFYSG FNKGKVLFHL NDEKSFSYDL
     FYTGDGVPVS FLKIYEDNKI IESEKFHLDV EISYVDSN
//