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Protein

Protein S-acyltransferase 24

Gene

PAT24

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase involved in cell growth regulation.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei401S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

  • acyl binding Source: TAIR
  • protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell tip growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S-acyltransferase 24 (EC:2.3.1.225)
Alternative name(s):
Ankyrin repeat-containing S-palmitoyltransferase
Palmitoyltransferase TIP1
Protein TIP GROWTH DEFECTIVE 1
Short name:
AtTIP1
Zinc finger DHHC domain-containing protein TIP1
Gene namesi
Name:PAT24
Synonyms:TIP1
Ordered Locus Names:At5g20350
ORF Names:F5O24.240
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G20350.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • endosome Source: TAIR
  • Golgi apparatus Source: TAIR
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Plants have defects in root hair growth and pollen tube germination.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129151 – 620Protein S-acyltransferase 24Add BLAST620

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ52T38.

PTM databases

iPTMnetiQ52T38.
SwissPalmiQ52T38.

Expressioni

Tissue specificityi

Expressed in root, leaf, inflorescence stem, pollen and floral tissue.2 Publications

Gene expression databases

ExpressionAtlasiQ52T38. baseline and differential.
GenevisibleiQ52T38. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G20350.1.

Structurei

3D structure databases

ProteinModelPortaliQ52T38.
SMRiQ52T38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 126ANK 2Add BLAST30
Repeati164 – 193ANK 3Add BLAST30
Repeati197 – 226ANK 4Add BLAST30
Repeati232 – 261ANK 5Add BLAST30
Domaini371 – 421DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
HOGENOMiHOG000243854.
InParanoidiQ52T38.
KOiK20032.
OMAiTDHGCAD.
OrthoDBiEOG093605DC.
PhylomeDBiQ52T38.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 7 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52T38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEIEVVEE IQSNPKENGE SSSKGIEEES LKNDVYTAAA YGDLEKLHRL
60 70 80 90 100
VECEGSSVSE PDALGYYALQ WSALNNRVAV AQYLIEHGGD VNATDHTGQT
110 120 130 140 150
ALHWSAVRGA IQVAELLLQE GARVDATDMY GYQATHVAAQ YGQTAFLCHV
160 170 180 190 200
VSKWNADPDV PDNDGRSPLH WAAYKGFADS IRLLLFLDAY RGRQDKEGCT
210 220 230 240 250
PLHWAAIRGN LEACTVLVQA GKKEDLMITD KTGLTPAQLA AEKNHRQVSF
260 270 280 290 300
FLGNARSLLE KRCDGSSPLG RLSKLGLAPV LWIMILLLLL VYTNSVVLAS
310 320 330 340 350
NLPKLTTGIG ALAWLGFILA TAGLFLFYRC SRKDPGYIRM NIHDPQTMKD
360 370 380 390 400
DEPLLKIELN NPALLAGNWT QLCATCKIIR PLRAKHCSTC DRCVEQFDHH
410 420 430 440 450
CPWVSNCVGK KNKWEFFLFL LLEVLAMLIT GGVTLARVLS DPSAPSSFGA
460 470 480 490 500
WMSHVASNHV GALSFLLVEF CLFFSVAVLT VIQASQISRN ITTNEMANAL
510 520 530 540 550
RYSYLRGPGG RFRNPYDLGC RRNCSDFLVK GYNEDIECHE EDATQRPEGI
560 570 580 590 600
SMMQMQRNPN LQNGNGHVAI DVNPTHNSQS AHVHSANCSH SHNSKSKSDN
610 620
VPLGLGLGLS RNPTRPVVSP
Length:620
Mass (Da):68,234
Last modified:May 24, 2005 - v1
Checksum:iBF6247CB99911659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY965346 mRNA. Translation: AAX89384.1.
AF296825 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92834.1.
AK228596 mRNA. Translation: BAF00511.1.
RefSeqiNP_197535.2. NM_122042.4.
UniGeneiAt.22462.

Genome annotation databases

EnsemblPlantsiAT5G20350.1; AT5G20350.1; AT5G20350.
GeneIDi832157.
GrameneiAT5G20350.1; AT5G20350.1; AT5G20350.
KEGGiath:AT5G20350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY965346 mRNA. Translation: AAX89384.1.
AF296825 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92834.1.
AK228596 mRNA. Translation: BAF00511.1.
RefSeqiNP_197535.2. NM_122042.4.
UniGeneiAt.22462.

3D structure databases

ProteinModelPortaliQ52T38.
SMRiQ52T38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G20350.1.

PTM databases

iPTMnetiQ52T38.
SwissPalmiQ52T38.

Proteomic databases

PaxDbiQ52T38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G20350.1; AT5G20350.1; AT5G20350.
GeneIDi832157.
GrameneiAT5G20350.1; AT5G20350.1; AT5G20350.
KEGGiath:AT5G20350.

Organism-specific databases

TAIRiAT5G20350.

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
HOGENOMiHOG000243854.
InParanoidiQ52T38.
KOiK20032.
OMAiTDHGCAD.
OrthoDBiEOG093605DC.
PhylomeDBiQ52T38.

Enzyme and pathway databases

BRENDAi2.3.1.225. 399.

Miscellaneous databases

PROiQ52T38.

Gene expression databases

ExpressionAtlasiQ52T38. baseline and differential.
GenevisibleiQ52T38. AT.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 7 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH22_ARATH
AccessioniPrimary (citable) accession number: Q52T38
Secondary accession number(s): Q0WQT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.