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Protein

Fibroblast growth factor receptor substrate 3

Gene

Frs3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor substrate 3
Short name:
FGFR substrate 3
Alternative name(s):
FGFR-signaling adaptor SNT2
Suc1-associated neurotrophic factor target 2
Short name:
SNT-2
Gene namesi
Name:Frs3
Synonyms:Snt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310226 Frs3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000873482 – 492Fibroblast growth factor receptor substrate 3Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ52RG8
PRIDEiQ52RG8

Interactioni

Subunit structurei

Binds NTRK1, FGFR1, NGFR, GRB2, PTPN11 and ERK2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019404

Structurei

3D structure databases

SMRiQ52RG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 115IRS-type PTBPROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
HOGENOMiHOG000290694
HOVERGENiHBG062705
InParanoidiQ52RG8
PhylomeDBiQ52RG8

Family and domain databases

CDDicd01202 PTB_FRS2, 1 hit
InterProiView protein in InterPro
IPR038742 FRS2_PTB
IPR002404 IRS_PTB
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52RG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCCSCLDR DSVPHNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH
60 70 80 90 100
QQEAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL
110 120 130 140 150
LQDLMQCNSI NVTEEPVIIT RNSHPQELDL PRGSSQPTGY TVSSFSNGFP
160 170 180 190 200
GCPGEGPRFS SAPRRPSTSS LRHPSPGEES TQTLIASDEQ SHTYVNTPTG
210 220 230 240 250
EEDRRSRHCL QPLPEGRVPF PPQTQVSDQR DPQVFLQPGQ VKFVLGPTPA
260 270 280 290 300
RRQVMKCQSL CPSMQDPPLH NNNEGPSECP AQPKCTYENV SGGLQQGAGW
310 320 330 340 350
RLSPEERGWS GLAHRRAALL HYENLPPLPP VWESQVQQLR GEAGDDGDSK
360 370 380 390 400
DGLTPSSNGF PDGEEDETPL QKPTSTRASA RSHSSFPVPL TRRRGSPRVF
410 420 430 440 450
NFDFRRPGPE PPRQLNYIQV ELKGWGTAHP KGPQNPSVSG APGPTPHPAR
460 470 480 490
SSDSYAVIDL KKTVAMSNLQ RALPRDDGTV RKTRHNSTDL PL
Length:492
Mass (Da):54,347
Last modified:January 23, 2007 - v3
Checksum:i0B93FCF5D4C9485B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY972083 mRNA Translation: AAX84972.1
RefSeqiNP_001017382.1, NM_001017382.1
UniGeneiRn.34398

Genome annotation databases

GeneIDi316213
KEGGirno:316213
UCSCiRGD:1310226 rat

Similar proteinsi

Entry informationi

Entry nameiFRS3_RAT
AccessioniPrimary (citable) accession number: Q52RG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health