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Protein

Fibroblast growth factor receptor substrate 3

Gene

Frs3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-170968. Frs2-mediated activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor substrate 3
Short name:
FGFR substrate 3
Alternative name(s):
FGFR-signaling adaptor SNT2
Suc1-associated neurotrophic factor target 2
Short name:
SNT-2
Gene namesi
Name:Frs3
Synonyms:Snt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310226. Frs3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 492491Fibroblast growth factor receptor substrate 3PRO_0000087348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Post-translational modificationi

Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ52RG8.
PRIDEiQ52RG8.

PTM databases

PhosphoSiteiQ52RG8.

Interactioni

Subunit structurei

Binds NTRK1, FGFR1, NGFR, GRB2, PTPN11 and ERK2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019404.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 115103IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
HOGENOMiHOG000290694.
HOVERGENiHBG062705.
InParanoidiQ52RG8.
PhylomeDBiQ52RG8.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52RG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCCSCLDR DSVPHNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH
60 70 80 90 100
QQEAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL
110 120 130 140 150
LQDLMQCNSI NVTEEPVIIT RNSHPQELDL PRGSSQPTGY TVSSFSNGFP
160 170 180 190 200
GCPGEGPRFS SAPRRPSTSS LRHPSPGEES TQTLIASDEQ SHTYVNTPTG
210 220 230 240 250
EEDRRSRHCL QPLPEGRVPF PPQTQVSDQR DPQVFLQPGQ VKFVLGPTPA
260 270 280 290 300
RRQVMKCQSL CPSMQDPPLH NNNEGPSECP AQPKCTYENV SGGLQQGAGW
310 320 330 340 350
RLSPEERGWS GLAHRRAALL HYENLPPLPP VWESQVQQLR GEAGDDGDSK
360 370 380 390 400
DGLTPSSNGF PDGEEDETPL QKPTSTRASA RSHSSFPVPL TRRRGSPRVF
410 420 430 440 450
NFDFRRPGPE PPRQLNYIQV ELKGWGTAHP KGPQNPSVSG APGPTPHPAR
460 470 480 490
SSDSYAVIDL KKTVAMSNLQ RALPRDDGTV RKTRHNSTDL PL
Length:492
Mass (Da):54,347
Last modified:January 23, 2007 - v3
Checksum:i0B93FCF5D4C9485B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY972083 mRNA. Translation: AAX84972.1.
RefSeqiNP_001017382.1. NM_001017382.1.
UniGeneiRn.34398.

Genome annotation databases

GeneIDi316213.
KEGGirno:316213.
UCSCiRGD:1310226. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY972083 mRNA. Translation: AAX84972.1.
RefSeqiNP_001017382.1. NM_001017382.1.
UniGeneiRn.34398.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019404.

PTM databases

PhosphoSiteiQ52RG8.

Proteomic databases

PaxDbiQ52RG8.
PRIDEiQ52RG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316213.
KEGGirno:316213.
UCSCiRGD:1310226. rat.

Organism-specific databases

CTDi10817.
RGDi1310226. Frs3.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
HOGENOMiHOG000290694.
HOVERGENiHBG062705.
InParanoidiQ52RG8.
PhylomeDBiQ52RG8.

Enzyme and pathway databases

ReactomeiR-RNO-170968. Frs2-mediated activation.

Miscellaneous databases

PROiQ52RG8.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cotton L.M., Gibbs G.M., Morrison J.R., de Kretser D.M., O'Bryan M.K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiFRS3_RAT
AccessioniPrimary (citable) accession number: Q52RG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.