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Protein

Potassium voltage-gated channel subfamily D member 1

Gene

KCND1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi104ZincBy similarity1
Metal bindingi131ZincBy similarity1
Metal bindingi132ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Metal-binding, Potassium, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-1296072. Voltage gated Potassium channels.
R-BTA-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily D member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv4.1
Gene namesi
Name:KCND1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 184CytoplasmicSequence analysisAdd BLAST184
Transmembranei185 – 205Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei227 – 247Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini248 – 261CytoplasmicSequence analysisAdd BLAST14
Transmembranei262 – 282Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini313 – 325CytoplasmicSequence analysisAdd BLAST13
Transmembranei326 – 346Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei365 – 385Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei387 – 407Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini408 – 648CytoplasmicSequence analysisAdd BLAST241

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002440291 – 648Potassium voltage-gated channel subfamily D member 1Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi352N-linked (GlcNAc...)Sequence analysis1
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Modified residuei458PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ52PG9.
PRIDEiQ52PG9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009024.

Interactioni

Subunit structurei

Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with DPP10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011882.

Structurei

3D structure databases

ProteinModelPortaliQ52PG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 20Interaction with KCNIP2By similarityAdd BLAST19
Regioni474 – 489Mediates dendritic targetingBy similarityAdd BLAST16

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi372 – 377Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4390. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231013.
HOVERGENiHBG106687.
InParanoidiQ52PG9.
KOiK04891.
OMAiPREQPCG.
OrthoDBiEOG091G18X0.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004054. K_chnl_volt-dep_Kv4.1.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01516. KV41CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52PG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGVATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR
60 70 80 90 100
FETWKNTLDR YPDTLLGSSE KEFFYNADSG EYFFDRDPDM FRHVLNFYRT
110 120 130 140 150
GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED
160 170 180 190 200
EEAEQAGDGP TLPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV
210 220 230 240 250
IANVVETIPC RSPTRRPPRE QPCGDRFPLA FFCMDTACVL IFTGEYLLRL
260 270 280 290 300
FAAPSRCRFL RSVMSLIDVV AILPYYIGLF MPKNEDVSGA FVTLRVFRVF
310 320 330 340 350
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG
360 370 380 390 400
TNKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI
410 420 430 440 450
ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK
460 470 480 490 500
QNGSLEDSGG GEEQALCVRN RSAFEQQHHH LLHCLEKTTC HEFTDELTFS
510 520 530 540 550
EALGAVSLGS RTSRSTSVSS QPVGAGSLLS SCCPRRAKRR AIRLANSTAS
560 570 580 590 600
VSRGSMQELD TLAGLRRSPA PQSRSSLNAK PHDSLDLTCD SRDFVAAIIS
610 620 630 640
IPTPPANTPD ESQPSSPGGG GGGASSTLRN SSLGTPCLLP ETVKISSL
Length:648
Mass (Da):71,378
Last modified:May 24, 2005 - v1
Checksum:iC2DDFB3A4D4A2D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY989810 mRNA. Translation: AAX89129.1.
RefSeqiNP_001019724.1. NM_001024553.1.
XP_010820207.1. XM_010821905.2.
UniGeneiBt.8644.

Genome annotation databases

EnsembliENSBTAT00000011882; ENSBTAP00000011882; ENSBTAG00000009024.
GeneIDi518384.
KEGGibta:518384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY989810 mRNA. Translation: AAX89129.1.
RefSeqiNP_001019724.1. NM_001024553.1.
XP_010820207.1. XM_010821905.2.
UniGeneiBt.8644.

3D structure databases

ProteinModelPortaliQ52PG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011882.

Proteomic databases

PaxDbiQ52PG9.
PRIDEiQ52PG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011882; ENSBTAP00000011882; ENSBTAG00000009024.
GeneIDi518384.
KEGGibta:518384.

Organism-specific databases

CTDi3750.

Phylogenomic databases

eggNOGiKOG4390. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231013.
HOVERGENiHBG106687.
InParanoidiQ52PG9.
KOiK04891.
OMAiPREQPCG.
OrthoDBiEOG091G18X0.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-BTA-1296072. Voltage gated Potassium channels.
R-BTA-5576894. Phase 1 - inactivation of fast Na+ channels.

Gene expression databases

BgeeiENSBTAG00000009024.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004054. K_chnl_volt-dep_Kv4.1.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01516. KV41CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCND1_BOVIN
AccessioniPrimary (citable) accession number: Q52PG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 24, 2005
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.