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Protein

Coiled-coil domain-containing protein 184

Gene

CCDC184

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 184
Gene namesi
Name:CCDC184
Synonyms:C12orf68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:33749. CCDC184.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377998.

Polymorphism and mutation databases

BioMutaiC12orf68.
DMDMi296434453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Coiled-coil domain-containing protein 184PRO_0000335681Add
BLAST

Proteomic databases

EPDiQ52MB2.
PaxDbiQ52MB2.
PRIDEiQ52MB2.

Expressioni

Gene expression databases

BgeeiQ52MB2.
CleanExiHS_C12orf68.
GenevisibleiQ52MB2. HS.

Organism-specific databases

HPAiHPA039947.
HPA041715.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GPANK1O958723EBI-10179526,EBI-751540
PBLDP300393EBI-10179526,EBI-750589
PIN1Q135263EBI-10179526,EBI-714158
PPP1R13BQ96KQ43EBI-10179526,EBI-1105153
RPL9P329693EBI-10179526,EBI-358122
STX11O755583EBI-10179526,EBI-714135
TRAF5O004633EBI-10179526,EBI-523498
WDYHV1Q96HA83EBI-10179526,EBI-741158

Protein-protein interaction databases

BioGridi132471. 9 interactions.
IntActiQ52MB2. 8 interactions.
MINTiMINT-4718558.
STRINGi9606.ENSP00000320849.

Structurei

3D structure databases

ProteinModelPortaliQ52MB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili39 – 6830Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 14611Poly-GluAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWAW. Eukaryota.
ENOG41115RJ. LUCA.
GeneTreeiENSGT00390000002978.
HOGENOMiHOG000111770.
HOVERGENiHBG095697.
InParanoidiQ52MB2.
OMAiTSHCERS.
OrthoDBiEOG72JWHM.
PhylomeDBiQ52MB2.
TreeFamiTF337201.

Family and domain databases

InterProiIPR031458. DUF4677.
[Graphical view]
PfamiPF15726. DUF4677. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52MB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGLLEIMT KDGGDMPAPL EVSTVPAVGD VISGEYNGGM KELMEHLKAQ
60 70 80 90 100
LQALFEDVRA MRGALDEQAS HIQVLSDDVC ANQRAIVSMC QIMTTAPRQG
110 120 130 140 150
GLGVVGGKGS FQSDPQEPET PSPGIGDSGL LGRDPEDEEE EEEEKEMPSP
160 170 180 190
ATPSSHCERP ESPCAGLLGG DGPLVEPLDM PDITLLQLEG EASL
Length:194
Mass (Da):20,484
Last modified:May 18, 2010 - v2
Checksum:i7281438BCDB2E313
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781D → G in BAB71071 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401E → D.2 Publications
Corresponds to variant rs10783231 [ dbSNP | Ensembl ].
VAR_060278

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056003 mRNA. Translation: BAB71071.1.
AK056783 mRNA. Translation: BAB71283.1.
AC074029 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57977.1.
BC036801 mRNA. Translation: AAH36801.1.
CCDSiCCDS31785.1.
RefSeqiNP_001013657.3. NM_001013635.3.
UniGeneiHs.251699.

Genome annotation databases

EnsembliENST00000316554; ENSP00000320849; ENSG00000177875.
GeneIDi387856.
KEGGihsa:387856.
UCSCiuc001rrj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056003 mRNA. Translation: BAB71071.1.
AK056783 mRNA. Translation: BAB71283.1.
AC074029 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57977.1.
BC036801 mRNA. Translation: AAH36801.1.
CCDSiCCDS31785.1.
RefSeqiNP_001013657.3. NM_001013635.3.
UniGeneiHs.251699.

3D structure databases

ProteinModelPortaliQ52MB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132471. 9 interactions.
IntActiQ52MB2. 8 interactions.
MINTiMINT-4718558.
STRINGi9606.ENSP00000320849.

Polymorphism and mutation databases

BioMutaiC12orf68.
DMDMi296434453.

Proteomic databases

EPDiQ52MB2.
PaxDbiQ52MB2.
PRIDEiQ52MB2.

Protocols and materials databases

DNASUi387856.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316554; ENSP00000320849; ENSG00000177875.
GeneIDi387856.
KEGGihsa:387856.
UCSCiuc001rrj.3. human.

Organism-specific databases

CTDi387856.
GeneCardsiCCDC184.
HGNCiHGNC:33749. CCDC184.
HPAiHPA039947.
HPA041715.
neXtProtiNX_Q52MB2.
PharmGKBiPA162377998.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWAW. Eukaryota.
ENOG41115RJ. LUCA.
GeneTreeiENSGT00390000002978.
HOGENOMiHOG000111770.
HOVERGENiHBG095697.
InParanoidiQ52MB2.
OMAiTSHCERS.
OrthoDBiEOG72JWHM.
PhylomeDBiQ52MB2.
TreeFamiTF337201.

Miscellaneous databases

GenomeRNAii387856.
NextBioi101680.
PROiQ52MB2.

Gene expression databases

BgeeiQ52MB2.
CleanExiHS_C12orf68.
GenevisibleiQ52MB2. HS.

Family and domain databases

InterProiIPR031458. DUF4677.
[Graphical view]
PfamiPF15726. DUF4677. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-140.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-140.
    Tissue: Brain.

Entry informationi

Entry nameiCC184_HUMAN
AccessioniPrimary (citable) accession number: Q52MB2
Secondary accession number(s): Q96MK5, Q96N39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.