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Protein

Zinc finger protein 585B

Gene

ZNF585B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri746 – 768C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30856-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 585B
Alternative name(s):
zinc finger protein 41-like protein
Gene namesi
Name:ZNF585B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30948. ZNF585B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000245680.
PharmGKBiPA134925877.

Polymorphism and mutation databases

BioMutaiZNF585B.
DMDMi74762154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476791 – 769Zinc finger protein 585BAdd BLAST769

Proteomic databases

MaxQBiQ52M93.
PaxDbiQ52M93.
PeptideAtlasiQ52M93.
PRIDEiQ52M93.

PTM databases

iPTMnetiQ52M93.
PhosphoSitePlusiQ52M93.

Expressioni

Gene expression databases

BgeeiENSG00000245680.
CleanExiHS_ZNF585B.
ExpressionAtlasiQ52M93. baseline and differential.
GenevisibleiQ52M93. HS.

Organism-specific databases

HPAiHPA046323.

Interactioni

Protein-protein interaction databases

BioGridi124927. 4 interactors.
IntActiQ52M93. 3 interactors.
MINTiMINT-1422231.
STRINGi9606.ENSP00000433773.

Structurei

3D structure databases

ProteinModelPortaliQ52M93.
SMRiQ52M93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 97KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 21 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri746 – 768C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ52M93.
KOiK09228.
OMAiHNQHRKI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ52M93.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52M93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDLSQRN
60 70 80 90 100
LYRDVMLETY SHLLSVGYQV PKPEVVMLEQ GKEPWALQGE RPRHSCPGEK
110 120 130 140 150
LWDHNQHRKI IGYKPASSQD QKIYSGEKSY ECAEFGKSFT WKSQFKVHLK
160 170 180 190 200
VPTGEKLYVC IECGRAFVQK PEFITHQKTH MREKPYKCNE CGKSFFQVSS
210 220 230 240 250
LFRHHRIHTG EKLYECSECG KGFPYNSDLS IHEKIHTGER HHECTDCGKA
260 270 280 290 300
FTQKSTLKIH QKIHTGERSY ICIECGQAFI QKTQLIAHRR IHSGEKPYEC
310 320 330 340 350
NNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LITHEKIQSR
360 370 380 390 400
EKSSICTECG KAFTYRSELI IHQRIHTGEK PYECSDCGRA FTQKSALTVH
410 420 430 440 450
QRIHTGEKSY ICMKCGLAFI RKAHLITHQI IHTGEKPYKC GHCGKLFTSK
460 470 480 490 500
SQLHVHKRIH TGEKPYVCNK CGKAFTNRSN LITHQKTHTG EKSYICSKCG
510 520 530 540 550
KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSNLNIH QKIHTGERQY
560 570 580 590 600
ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
610 620 630 640 650
TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS
660 670 680 690 700
KHQKTHTGEK PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT
710 720 730 740 750
KKSQLQVHQR IHTGEKPYVC AECGKAFSNR SNLNKHQTTH TGDKPYKCGI
760
CGKGFVQKSV FSVHQSSHA
Length:769
Mass (Da):88,066
Last modified:May 24, 2005 - v1
Checksum:iEA70D74DE81536FF
GO

Sequence cautioni

The sequence BAB55400 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186Y → P in AAN61169 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059923467V → I.Corresponds to variant rs1657509dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147015 mRNA. Translation: AAN61169.1.
BC093625 mRNA. Translation: AAH93625.1.
AK027834 mRNA. Translation: BAB55400.1. Different initiation.
CCDSiCCDS12500.1.
RefSeqiNP_689492.3. NM_152279.3.
UniGeneiHs.390568.

Genome annotation databases

EnsembliENST00000532828; ENSP00000433773; ENSG00000245680.
GeneIDi92285.
KEGGihsa:92285.
UCSCiuc002ofq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147015 mRNA. Translation: AAN61169.1.
BC093625 mRNA. Translation: AAH93625.1.
AK027834 mRNA. Translation: BAB55400.1. Different initiation.
CCDSiCCDS12500.1.
RefSeqiNP_689492.3. NM_152279.3.
UniGeneiHs.390568.

3D structure databases

ProteinModelPortaliQ52M93.
SMRiQ52M93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124927. 4 interactors.
IntActiQ52M93. 3 interactors.
MINTiMINT-1422231.
STRINGi9606.ENSP00000433773.

PTM databases

iPTMnetiQ52M93.
PhosphoSitePlusiQ52M93.

Polymorphism and mutation databases

BioMutaiZNF585B.
DMDMi74762154.

Proteomic databases

MaxQBiQ52M93.
PaxDbiQ52M93.
PeptideAtlasiQ52M93.
PRIDEiQ52M93.

Protocols and materials databases

DNASUi92285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532828; ENSP00000433773; ENSG00000245680.
GeneIDi92285.
KEGGihsa:92285.
UCSCiuc002ofq.3. human.

Organism-specific databases

CTDi92285.
GeneCardsiZNF585B.
HGNCiHGNC:30948. ZNF585B.
HPAiHPA046323.
neXtProtiNX_Q52M93.
OpenTargetsiENSG00000245680.
PharmGKBiPA134925877.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ52M93.
KOiK09228.
OMAiHNQHRKI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ52M93.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-30856-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii92285.
PROiQ52M93.

Gene expression databases

BgeeiENSG00000245680.
CleanExiHS_ZNF585B.
ExpressionAtlasiQ52M93. baseline and differential.
GenevisibleiQ52M93. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ585B_HUMAN
AccessioniPrimary (citable) accession number: Q52M93
Secondary accession number(s): Q8IZD3, Q96JW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.