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Protein

Enhancer of polycomb homolog 2

Gene

EPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcription or DNA repair.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of polycomb homolog 2
Alternative name(s):
EPC-like
Gene namesi
Name:EPC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24543. EPC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875170.

Polymorphism and mutation databases

BioMutaiEPC2.
DMDMi108935980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Enhancer of polycomb homolog 2PRO_0000239295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki324 – 324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei538 – 5381PhosphoserineCombined sources
Modified residuei754 – 7541PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ52LR7.
MaxQBiQ52LR7.
PaxDbiQ52LR7.
PeptideAtlasiQ52LR7.
PRIDEiQ52LR7.

PTM databases

iPTMnetiQ52LR7.
PhosphoSiteiQ52LR7.

Expressioni

Gene expression databases

BgeeiENSG00000135999.
CleanExiHS_EPC2.
ExpressionAtlasiQ52LR7. baseline and differential.
GenevisibleiQ52LR7. HS.

Organism-specific databases

HPAiHPA036759.

Interactioni

Protein-protein interaction databases

BioGridi117564. 23 interactions.
IntActiQ52LR7. 11 interactions.
STRINGi9606.ENSP00000258484.

Structurei

3D structure databases

ProteinModelPortaliQ52LR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi483 – 4886Poly-Ser
Compositional biasi582 – 61938Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the enhancer of polycomb family.Curated

Phylogenomic databases

eggNOGiKOG2261. Eukaryota.
ENOG410XSSX. LUCA.
GeneTreeiENSGT00390000013262.
HOVERGENiHBG051489.
InParanoidiQ52LR7.
KOiK11322.
OMAiETTVAME.
OrthoDBiEOG091G0252.
PhylomeDBiQ52LR7.
TreeFamiTF106438.

Family and domain databases

InterProiIPR024943. Enhancer_polycomb.
IPR019542. Enhancer_polycomb-like_N.
IPR009607. Enhancer_polycomb_C.
[Graphical view]
PANTHERiPTHR14898. PTHR14898. 1 hit.
PfamiPF06752. E_Pc_C. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52LR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSFRARA LDAAKPLPIY RGKDMPDLND CVSINRAVPQ MPTGMEKEEE
60 70 80 90 100
SEHHLQRAIS AQQVFREKKE SMVIPVPEAE SNVNYYNRLY KGEFKQPKQF
110 120 130 140 150
IHIQPFNLDN EQPDYDMDSE DETLLNRLNR KMEIKPLQFE IMIDRLEKAS
160 170 180 190 200
SNQLVTLQEA KLLLNEDDYL IKAVYDYWVR KRKNCRGPSL IPQIKQEKRD
210 220 230 240 250
GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE FSRAITILEM
260 270 280 290 300
IKRREKTKRE LLHLTLEVVE KRYHLGDYGG EILNEVKISR SEKELYATPA
310 320 330 340 350
TLHNGNHHKV QECKTKHPHH LSLKEEASDV VRQKKKYPKK PKAEALITSQ
360 370 380 390 400
QPTPETLPVI NKSDIKQYDF HSSDEDEFPQ VLSPVSEPEE ENDPDGPCAF
410 420 430 440 450
RRRAGCQYYA PRLDQANHSC ENSELADLDK LRYRHCLTTL TVPRRCIGFA
460 470 480 490 500
RRRIGRGGRV IMDRISTEHD PVLKQIDPEM LNSFSSSSQT IDFSSNFSRT
510 520 530 540 550
NASSKHCENR LSLSEILSNI RSCRLQCFQP RLLNLQDSDS EECTSRKPGQ
560 570 580 590 600
TVNNKRVSAA SVALLNTSKN GISVTGGITE EQFQTHQQQL VQMQRQQLAQ
610 620 630 640 650
LQQKQQSQHS SQQTHPKAQG SSTSDCMSKT LDSASAHFAA SAVVSAPVPS
660 670 680 690 700
RSEVAKEQNT GHNNINGVVQ PSGTSKTLYS TNMALSSSPG ISAVQLVRTV
710 720 730 740 750
GHTTTNHLIP ALCTSSPQTL PMNNSCLTNA VHLNNVSVVS PVNVHINTRT
760 770 780 790 800
SAPSPTALKL ATVAASMDRV PKVTPSSAIS SIARENHEPE RLGLNGIAET

TVAMEVT
Length:807
Mass (Da):91,095
Last modified:June 13, 2006 - v2
Checksum:i855433050972CA7C
GO

Sequence cautioni

The sequence AAH93818 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH93820 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAK60500 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91688 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA92032 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti723 – 7231N → D in CAB55993 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286904 mRNA. Translation: AAK60500.1. Different initiation.
AK002010 mRNA. Translation: BAA92032.1. Different initiation.
AK001433 mRNA. Translation: BAA91688.1. Different initiation.
AK125789 mRNA. Translation: BAG54249.1.
CH471058 Genomic DNA. Translation: EAX11547.1.
CH471058 Genomic DNA. Translation: EAX11548.1.
BC093818 mRNA. Translation: AAH93818.1. Different initiation.
BC093820 mRNA. Translation: AAH93820.1. Different initiation.
AL117558 mRNA. Translation: CAB55993.1.
CCDSiCCDS46422.1.
PIRiT17303.
RefSeqiNP_056445.3. NM_015630.3.
UniGeneiHs.23270.

Genome annotation databases

EnsembliENST00000258484; ENSP00000258484; ENSG00000135999.
GeneIDi26122.
KEGGihsa:26122.
UCSCiuc010zbt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286904 mRNA. Translation: AAK60500.1. Different initiation.
AK002010 mRNA. Translation: BAA92032.1. Different initiation.
AK001433 mRNA. Translation: BAA91688.1. Different initiation.
AK125789 mRNA. Translation: BAG54249.1.
CH471058 Genomic DNA. Translation: EAX11547.1.
CH471058 Genomic DNA. Translation: EAX11548.1.
BC093818 mRNA. Translation: AAH93818.1. Different initiation.
BC093820 mRNA. Translation: AAH93820.1. Different initiation.
AL117558 mRNA. Translation: CAB55993.1.
CCDSiCCDS46422.1.
PIRiT17303.
RefSeqiNP_056445.3. NM_015630.3.
UniGeneiHs.23270.

3D structure databases

ProteinModelPortaliQ52LR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117564. 23 interactions.
IntActiQ52LR7. 11 interactions.
STRINGi9606.ENSP00000258484.

PTM databases

iPTMnetiQ52LR7.
PhosphoSiteiQ52LR7.

Polymorphism and mutation databases

BioMutaiEPC2.
DMDMi108935980.

Proteomic databases

EPDiQ52LR7.
MaxQBiQ52LR7.
PaxDbiQ52LR7.
PeptideAtlasiQ52LR7.
PRIDEiQ52LR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258484; ENSP00000258484; ENSG00000135999.
GeneIDi26122.
KEGGihsa:26122.
UCSCiuc010zbt.3. human.

Organism-specific databases

CTDi26122.
GeneCardsiEPC2.
HGNCiHGNC:24543. EPC2.
HPAiHPA036759.
MIMi611000. gene.
neXtProtiNX_Q52LR7.
PharmGKBiPA134875170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2261. Eukaryota.
ENOG410XSSX. LUCA.
GeneTreeiENSGT00390000013262.
HOVERGENiHBG051489.
InParanoidiQ52LR7.
KOiK11322.
OMAiETTVAME.
OrthoDBiEOG091G0252.
PhylomeDBiQ52LR7.
TreeFamiTF106438.

Miscellaneous databases

ChiTaRSiEPC2. human.
GenomeRNAii26122.
PROiQ52LR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135999.
CleanExiHS_EPC2.
ExpressionAtlasiQ52LR7. baseline and differential.
GenevisibleiQ52LR7. HS.

Family and domain databases

InterProiIPR024943. Enhancer_polycomb.
IPR019542. Enhancer_polycomb-like_N.
IPR009607. Enhancer_polycomb_C.
[Graphical view]
PANTHERiPTHR14898. PTHR14898. 1 hit.
PfamiPF06752. E_Pc_C. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPC2_HUMAN
AccessioniPrimary (citable) accession number: Q52LR7
Secondary accession number(s): B3KWT7
, D3DP89, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.