ID   RFTN2_HUMAN             Reviewed;         501 AA.
AC   Q52LD8; Q14DH4; Q2TA69; Q53QE0; Q53SE1; Q96NM3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 3.
DT   24-JAN-2024, entry version 137.
DE   RecName: Full=Raftlin-2;
DE   AltName: Full=Raft-linking protein 2;
GN   Name=RFTN2; Synonyms=C2orf11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Upon bacterial lipopolysaccharide stimulation, mediates
CC       clathrin-dependent internalization of TLR4 in dendritic cells,
CC       resulting in activation of TICAM1-mediated signaling and subsequent
CC       IFNB1 production. May regulate B-cell antigen receptor-mediated
CC       signaling. {ECO:0000250|UniProtKB:Q8CHX7}.
CC   -!- INTERACTION:
CC       Q52LD8; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12278276, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14699};
CC       Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
CC   -!- SIMILARITY: Belongs to the raftlin family. {ECO:0000305}.
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DR   EMBL; AK055136; BAB70861.1; -; mRNA.
DR   EMBL; AC020550; AAX93148.1; -; Genomic_DNA.
DR   EMBL; AC114800; AAY24079.1; -; Genomic_DNA.
DR   EMBL; CH471063; EAW70169.1; -; Genomic_DNA.
DR   EMBL; BC093966; AAH93966.1; -; mRNA.
DR   EMBL; BC111069; AAI11070.1; -; mRNA.
DR   EMBL; BC113361; AAI13362.1; -; mRNA.
DR   CCDS; CCDS2323.1; -.
DR   RefSeq; NP_653230.2; NM_144629.2.
DR   AlphaFoldDB; Q52LD8; -.
DR   SMR; Q52LD8; -.
DR   BioGRID; 126225; 13.
DR   IntAct; Q52LD8; 8.
DR   STRING; 9606.ENSP00000295049; -.
DR   iPTMnet; Q52LD8; -.
DR   PhosphoSitePlus; Q52LD8; -.
DR   BioMuta; RFTN2; -.
DR   DMDM; 134047878; -.
DR   jPOST; Q52LD8; -.
DR   MassIVE; Q52LD8; -.
DR   MaxQB; Q52LD8; -.
DR   PaxDb; 9606-ENSP00000295049; -.
DR   PeptideAtlas; Q52LD8; -.
DR   ProteomicsDB; 62422; -.
DR   Antibodypedia; 34069; 137 antibodies from 25 providers.
DR   DNASU; 130132; -.
DR   Ensembl; ENST00000295049.9; ENSP00000295049.3; ENSG00000162944.11.
DR   GeneID; 130132; -.
DR   KEGG; hsa:130132; -.
DR   MANE-Select; ENST00000295049.9; ENSP00000295049.3; NM_144629.3; NP_653230.2.
DR   UCSC; uc002uuo.5; human.
DR   AGR; HGNC:26402; -.
DR   CTD; 130132; -.
DR   DisGeNET; 130132; -.
DR   GeneCards; RFTN2; -.
DR   HGNC; HGNC:26402; RFTN2.
DR   HPA; ENSG00000162944; Tissue enhanced (brain).
DR   MIM; 618215; gene.
DR   neXtProt; NX_Q52LD8; -.
DR   OpenTargets; ENSG00000162944; -.
DR   PharmGKB; PA162401231; -.
DR   VEuPathDB; HostDB:ENSG00000162944; -.
DR   eggNOG; ENOG502QVRY; Eukaryota.
DR   GeneTree; ENSGT00530000063609; -.
DR   HOGENOM; CLU_025878_0_0_1; -.
DR   InParanoid; Q52LD8; -.
DR   OMA; SWTYQEG; -.
DR   OrthoDB; 5356003at2759; -.
DR   PhylomeDB; Q52LD8; -.
DR   TreeFam; TF333285; -.
DR   PathwayCommons; Q52LD8; -.
DR   SignaLink; Q52LD8; -.
DR   BioGRID-ORCS; 130132; 9 hits in 1140 CRISPR screens.
DR   ChiTaRS; RFTN2; human.
DR   GenomeRNAi; 130132; -.
DR   Pharos; Q52LD8; Tdark.
DR   PRO; PR:Q52LD8; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q52LD8; Protein.
DR   Bgee; ENSG00000162944; Expressed in ventricular zone and 132 other cell types or tissues.
DR   ExpressionAtlas; Q52LD8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033227; P:dsRNA transport; IEA:Ensembl.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR   InterPro; IPR028169; Raftlin.
DR   PANTHER; PTHR17601:SF1; RAFTLIN-2; 1.
DR   PANTHER; PTHR17601; RAFTLIN-RELATED; 1.
DR   Pfam; PF15250; Raftlin; 1.
DR   Genevisible; Q52LD8; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Myristate; Palmitate; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..501
FT                   /note="Raftlin-2"
FT                   /id="PRO_0000089338"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..428
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         405
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CHX7"
FT   MOD_RES         409
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CHX7"
FT   MOD_RES         430
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CHX7"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
FT   LIPID           3
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        416
FT                   /note="R -> H (in Ref. 1; BAB70861)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   501 AA;  55922 MW;  8DABA620EDE03E75 CRC64;
     MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN PEVIKINSIL
     DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV VLLRLKLSPK NSAAPSGQRR
     PRLVIEECPL TSEAQTNDAA KELIEKINVA AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI
     ESMLHVRHGS DENCRSWNEG TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA
     SDNKLYTVFN AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID
     SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE GCEIKTDYGP
     LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP VMWNSAAQTP DKKASRHIKG
     EDKNKATSRS IGLDTTSSQP AESRHLPEEC RLSPSRECWT KEGRLAQHNS FSGFSSSDNV
     LRELDDGQFD QEDGVTQVTC M
//