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Protein

Raftlin-2

Gene

RFTN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Raftlin-2
Alternative name(s):
Raft-linking protein 2
Gene namesi
Name:RFTN2
Synonyms:C2orf11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162944.10
HGNCiHGNC:26402 RFTN2
neXtProtiNX_Q52LD8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162944
PharmGKBiPA162401231

Polymorphism and mutation databases

BioMutaiRFTN2
DMDMi134047878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000893382 – 501Raftlin-2Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei409PhosphothreonineBy similarity1
Modified residuei430PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ52LD8
PaxDbiQ52LD8
PeptideAtlasiQ52LD8
PRIDEiQ52LD8
ProteomicsDBi62422

PTM databases

iPTMnetiQ52LD8
PhosphoSitePlusiQ52LD8

Expressioni

Gene expression databases

BgeeiENSG00000162944
CleanExiHS_RFTN2
ExpressionAtlasiQ52LD8 baseline and differential
GenevisibleiQ52LD8 HS

Organism-specific databases

HPAiHPA035232

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502224EBI-12278276,EBI-748397

Protein-protein interaction databases

BioGridi126225, 8 interactors
IntActiQ52LD8, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ52LD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the raftlin family.Curated

Phylogenomic databases

eggNOGiENOG410IH0B Eukaryota
ENOG410YAW3 LUCA
GeneTreeiENSGT00530000063609
HOGENOMiHOG000121785
HOVERGENiHBG054056
InParanoidiQ52LD8
OMAiGMKFVGF
OrthoDBiEOG091G07W6
PhylomeDBiQ52LD8
TreeFamiTF333285

Family and domain databases

InterProiView protein in InterPro
IPR028169 Raftlin
PANTHERiPTHR17601 PTHR17601, 1 hit
PfamiView protein in Pfam
PF15250 Raftlin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52LD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN
60 70 80 90 100
PEVIKINSIL DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV
110 120 130 140 150
VLLRLKLSPK NSAAPSGQRR PRLVIEECPL TSEAQTNDAA KELIEKINVA
160 170 180 190 200
AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI ESMLHVRHGS DENCRSWNEG
210 220 230 240 250
TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA SDNKLYTVFN
260 270 280 290 300
AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID
310 320 330 340 350
SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE
360 370 380 390 400
GCEIKTDYGP LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP
410 420 430 440 450
VMWNSAAQTP DKKASRHIKG EDKNKATSRS IGLDTTSSQP AESRHLPEEC
460 470 480 490 500
RLSPSRECWT KEGRLAQHNS FSGFSSSDNV LRELDDGQFD QEDGVTQVTC

M
Length:501
Mass (Da):55,922
Last modified:March 20, 2007 - v3
Checksum:i8DABA620EDE03E75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416R → H in BAB70861 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055136 mRNA Translation: BAB70861.1
AC020550 Genomic DNA Translation: AAX93148.1
AC114800 Genomic DNA Translation: AAY24079.1
CH471063 Genomic DNA Translation: EAW70169.1
BC093966 mRNA Translation: AAH93966.1
BC111069 mRNA Translation: AAI11070.1
BC113361 mRNA Translation: AAI13362.1
CCDSiCCDS2323.1
RefSeqiNP_653230.2, NM_144629.2
UniGeneiHs.591615

Genome annotation databases

EnsembliENST00000295049; ENSP00000295049; ENSG00000162944
GeneIDi130132
KEGGihsa:130132
UCSCiuc002uuo.5 human

Similar proteinsi

Entry informationi

Entry nameiRFTN2_HUMAN
AccessioniPrimary (citable) accession number: Q52LD8
Secondary accession number(s): Q14DH4
, Q2TA69, Q53QE0, Q53SE1, Q96NM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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