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Q52LD8

- RFTN2_HUMAN

UniProt

Q52LD8 - RFTN2_HUMAN

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Protein

Raftlin-2

Gene

RFTN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. dsRNA transport Source: Ensembl
  2. response to exogenous dsRNA Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Raftlin-2
Alternative name(s):
Raft-linking protein 2
Gene namesi
Name:RFTN2
Synonyms:C2orf11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26402. RFTN2.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401231.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 501500Raftlin-2PRO_0000089338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDbiQ52LD8.
PRIDEiQ52LD8.

PTM databases

PhosphoSiteiQ52LD8.

Expressioni

Gene expression databases

BgeeiQ52LD8.
CleanExiHS_RFTN2.
ExpressionAtlasiQ52LD8. baseline and differential.
GenevestigatoriQ52LD8.

Organism-specific databases

HPAiHPA035232.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295049.

Structurei

3D structure databases

ProteinModelPortaliQ52LD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the raftlin family.Curated

Phylogenomic databases

eggNOGiNOG43823.
GeneTreeiENSGT00530000063609.
HOGENOMiHOG000121785.
HOVERGENiHBG054056.
InParanoidiQ52LD8.
OMAiLYTVFNV.
OrthoDBiEOG7034GW.
PhylomeDBiQ52LD8.
TreeFamiTF333285.

Family and domain databases

InterProiIPR028169. Raftlin.
[Graphical view]
PfamiPF15250. Raftlin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52LD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN
60 70 80 90 100
PEVIKINSIL DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV
110 120 130 140 150
VLLRLKLSPK NSAAPSGQRR PRLVIEECPL TSEAQTNDAA KELIEKINVA
160 170 180 190 200
AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI ESMLHVRHGS DENCRSWNEG
210 220 230 240 250
TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA SDNKLYTVFN
260 270 280 290 300
AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID
310 320 330 340 350
SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE
360 370 380 390 400
GCEIKTDYGP LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP
410 420 430 440 450
VMWNSAAQTP DKKASRHIKG EDKNKATSRS IGLDTTSSQP AESRHLPEEC
460 470 480 490 500
RLSPSRECWT KEGRLAQHNS FSGFSSSDNV LRELDDGQFD QEDGVTQVTC

M
Length:501
Mass (Da):55,922
Last modified:March 20, 2007 - v3
Checksum:i8DABA620EDE03E75
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti416 – 4161R → H in BAB70861. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055136 mRNA. Translation: BAB70861.1.
AC020550 Genomic DNA. Translation: AAX93148.1.
AC114800 Genomic DNA. Translation: AAY24079.1.
CH471063 Genomic DNA. Translation: EAW70169.1.
BC093966 mRNA. Translation: AAH93966.1.
BC111069 mRNA. Translation: AAI11070.1.
BC113361 mRNA. Translation: AAI13362.1.
CCDSiCCDS2323.1.
RefSeqiNP_653230.2. NM_144629.2.
UniGeneiHs.591615.

Genome annotation databases

EnsembliENST00000295049; ENSP00000295049; ENSG00000162944.
GeneIDi130132.
KEGGihsa:130132.
UCSCiuc002uuo.4. human.

Polymorphism databases

DMDMi134047878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055136 mRNA. Translation: BAB70861.1 .
AC020550 Genomic DNA. Translation: AAX93148.1 .
AC114800 Genomic DNA. Translation: AAY24079.1 .
CH471063 Genomic DNA. Translation: EAW70169.1 .
BC093966 mRNA. Translation: AAH93966.1 .
BC111069 mRNA. Translation: AAI11070.1 .
BC113361 mRNA. Translation: AAI13362.1 .
CCDSi CCDS2323.1.
RefSeqi NP_653230.2. NM_144629.2.
UniGenei Hs.591615.

3D structure databases

ProteinModelPortali Q52LD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000295049.

PTM databases

PhosphoSitei Q52LD8.

Polymorphism databases

DMDMi 134047878.

Proteomic databases

PaxDbi Q52LD8.
PRIDEi Q52LD8.

Protocols and materials databases

DNASUi 130132.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295049 ; ENSP00000295049 ; ENSG00000162944 .
GeneIDi 130132.
KEGGi hsa:130132.
UCSCi uc002uuo.4. human.

Organism-specific databases

CTDi 130132.
GeneCardsi GC02M198435.
H-InvDB HIX0002711.
HGNCi HGNC:26402. RFTN2.
HPAi HPA035232.
neXtProti NX_Q52LD8.
PharmGKBi PA162401231.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43823.
GeneTreei ENSGT00530000063609.
HOGENOMi HOG000121785.
HOVERGENi HBG054056.
InParanoidi Q52LD8.
OMAi LYTVFNV.
OrthoDBi EOG7034GW.
PhylomeDBi Q52LD8.
TreeFami TF333285.

Miscellaneous databases

ChiTaRSi RFTN2. human.
GenomeRNAii 130132.
NextBioi 82712.
PROi Q52LD8.

Gene expression databases

Bgeei Q52LD8.
CleanExi HS_RFTN2.
ExpressionAtlasi Q52LD8. baseline and differential.
Genevestigatori Q52LD8.

Family and domain databases

InterProi IPR028169. Raftlin.
[Graphical view ]
Pfami PF15250. Raftlin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRFTN2_HUMAN
AccessioniPrimary (citable) accession number: Q52LD8
Secondary accession number(s): Q14DH4
, Q2TA69, Q53QE0, Q53SE1, Q96NM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 20, 2007
Last modified: November 26, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3