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Q52LD8

- RFTN2_HUMAN

UniProt

Q52LD8 - RFTN2_HUMAN

Protein

Raftlin-2

Gene

RFTN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (20 Mar 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Raftlin-2
    Alternative name(s):
    Raft-linking protein 2
    Gene namesi
    Name:RFTN2
    Synonyms:C2orf11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:26402. RFTN2.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162401231.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 501500Raftlin-2PRO_0000089338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate

    Proteomic databases

    PaxDbiQ52LD8.
    PRIDEiQ52LD8.

    PTM databases

    PhosphoSiteiQ52LD8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ52LD8.
    BgeeiQ52LD8.
    CleanExiHS_RFTN2.
    GenevestigatoriQ52LD8.

    Organism-specific databases

    HPAiHPA035232.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000295049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ52LD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the raftlin family.Curated

    Phylogenomic databases

    eggNOGiNOG43823.
    HOGENOMiHOG000121785.
    HOVERGENiHBG054056.
    InParanoidiQ52LD8.
    OMAiLYTVFNV.
    OrthoDBiEOG7034GW.
    PhylomeDBiQ52LD8.
    TreeFamiTF333285.

    Family and domain databases

    InterProiIPR028169. Raftlin.
    [Graphical view]
    PfamiPF15250. Raftlin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q52LD8-1 [UniParc]FASTAAdd to Basket

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    MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN    50
    PEVIKINSIL DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV 100
    VLLRLKLSPK NSAAPSGQRR PRLVIEECPL TSEAQTNDAA KELIEKINVA 150
    AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI ESMLHVRHGS DENCRSWNEG 200
    TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA SDNKLYTVFN 250
    AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID 300
    SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE 350
    GCEIKTDYGP LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP 400
    VMWNSAAQTP DKKASRHIKG EDKNKATSRS IGLDTTSSQP AESRHLPEEC 450
    RLSPSRECWT KEGRLAQHNS FSGFSSSDNV LRELDDGQFD QEDGVTQVTC 500
    M 501
    Length:501
    Mass (Da):55,922
    Last modified:March 20, 2007 - v3
    Checksum:i8DABA620EDE03E75
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti416 – 4161R → H in BAB70861. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055136 mRNA. Translation: BAB70861.1.
    AC020550 Genomic DNA. Translation: AAX93148.1.
    AC114800 Genomic DNA. Translation: AAY24079.1.
    CH471063 Genomic DNA. Translation: EAW70169.1.
    BC093966 mRNA. Translation: AAH93966.1.
    BC111069 mRNA. Translation: AAI11070.1.
    BC113361 mRNA. Translation: AAI13362.1.
    CCDSiCCDS2323.1.
    RefSeqiNP_653230.2. NM_144629.2.
    UniGeneiHs.591615.

    Genome annotation databases

    EnsembliENST00000295049; ENSP00000295049; ENSG00000162944.
    GeneIDi130132.
    KEGGihsa:130132.
    UCSCiuc002uuo.4. human.

    Polymorphism databases

    DMDMi134047878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055136 mRNA. Translation: BAB70861.1 .
    AC020550 Genomic DNA. Translation: AAX93148.1 .
    AC114800 Genomic DNA. Translation: AAY24079.1 .
    CH471063 Genomic DNA. Translation: EAW70169.1 .
    BC093966 mRNA. Translation: AAH93966.1 .
    BC111069 mRNA. Translation: AAI11070.1 .
    BC113361 mRNA. Translation: AAI13362.1 .
    CCDSi CCDS2323.1.
    RefSeqi NP_653230.2. NM_144629.2.
    UniGenei Hs.591615.

    3D structure databases

    ProteinModelPortali Q52LD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000295049.

    PTM databases

    PhosphoSitei Q52LD8.

    Polymorphism databases

    DMDMi 134047878.

    Proteomic databases

    PaxDbi Q52LD8.
    PRIDEi Q52LD8.

    Protocols and materials databases

    DNASUi 130132.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295049 ; ENSP00000295049 ; ENSG00000162944 .
    GeneIDi 130132.
    KEGGi hsa:130132.
    UCSCi uc002uuo.4. human.

    Organism-specific databases

    CTDi 130132.
    GeneCardsi GC02M198435.
    H-InvDB HIX0002711.
    HGNCi HGNC:26402. RFTN2.
    HPAi HPA035232.
    neXtProti NX_Q52LD8.
    PharmGKBi PA162401231.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43823.
    HOGENOMi HOG000121785.
    HOVERGENi HBG054056.
    InParanoidi Q52LD8.
    OMAi LYTVFNV.
    OrthoDBi EOG7034GW.
    PhylomeDBi Q52LD8.
    TreeFami TF333285.

    Miscellaneous databases

    GenomeRNAii 130132.
    NextBioi 82712.
    PROi Q52LD8.

    Gene expression databases

    ArrayExpressi Q52LD8.
    Bgeei Q52LD8.
    CleanExi HS_RFTN2.
    Genevestigatori Q52LD8.

    Family and domain databases

    InterProi IPR028169. Raftlin.
    [Graphical view ]
    Pfami PF15250. Raftlin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRFTN2_HUMAN
    AccessioniPrimary (citable) accession number: Q52LD8
    Secondary accession number(s): Q14DH4
    , Q2TA69, Q53QE0, Q53SE1, Q96NM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3