Q52LD8 (RFTN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Raftlin-2

Alternative name(s):
Raft-linking protein 2

Gene names

Name:	RFTN2
Synonyms:	C2orf11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor By similarity.
Sequence similarities	Belongs to the raftlin family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
PTM	Lipoprotein Myristate Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Raftlin-2		PRO_0000089338
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
	Lipidation	3	1	S-palmitoyl cysteine By similarity
Experimental info
	Sequence conflict	416	1	R → H in BAB70861. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q52LD8 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: 8DABA620EDE03E75	FASTA	501	55,922
	10 20 30 40 50 60 MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN PEVIKINSIL 70 80 90 100 110 120 DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV VLLRLKLSPK NSAAPSGQRR 130 140 150 160 170 180 PRLVIEECPL TSEAQTNDAA KELIEKINVA AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI 190 200 210 220 230 240 ESMLHVRHGS DENCRSWNEG TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA 250 260 270 280 290 300 SDNKLYTVFN AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID 310 320 330 340 350 360 SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE GCEIKTDYGP 370 380 390 400 410 420 LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP VMWNSAAQTP DKKASRHIKG 430 440 450 460 470 480 EDKNKATSRS IGLDTTSSQP AESRHLPEEC RLSPSRECWT KEGRLAQHNS FSGFSSSDNV 490 500 LRELDDGQFD QEDGVTQVTC M

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055136 mRNA. Translation: BAB70861.1. AC020550 Genomic DNA. Translation: AAX93148.1. AC114800 Genomic DNA. Translation: AAY24079.1. CH471063 Genomic DNA. Translation: EAW70169.1. BC093966 mRNA. Translation: AAH93966.1. BC111069 mRNA. Translation: AAI11070.1. BC113361 mRNA. Translation: AAI13362.1.
IPI	IPI00043747.
RefSeq	NP_653230.2. NM_144629.2.
UniGene	Hs.591615.
3D structure databases
ProteinModelPortal	Q52LD8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000295049.
PTM databases
PhosphoSite	Q52LD8.
Polymorphism databases
DMDM	134047878.
Proteomic databases
PaxDb	Q52LD8.
PRIDE	Q52LD8.
Protocols and materials databases
DNASU	130132.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295049; ENSP00000295049; ENSG00000162944.
GeneID	130132.
KEGG	hsa:130132.
UCSC	uc002uuo.4. human.
Organism-specific databases
CTD	130132.
GeneCards	GC02M198435.
H-InvDB	HIX0002711.
HGNC	HGNC:26402. RFTN2.
HPA	HPA035232.
neXtProt	NX_Q52LD8.
PharmGKB	PA162401231.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43823.
HOGENOM	HOG000121785.
HOVERGEN	HBG054056.
InParanoid	Q52LD8.
OMA	AQTPERK.
OrthoDB	EOG4X0MSQ.
PhylomeDB	Q52LD8.
Gene expression databases
ArrayExpress	Q52LD8.
Bgee	Q52LD8.
CleanEx	HS_RFTN2.
Genevestigator	Q52LD8.
GermOnline	ENSG00000162944. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	130132.
NextBio	82712.

Entry information

Entry name

RFTN2_HUMAN

Accession

Primary (citable) accession number: Q52LD8
Secondary accession number(s): Q14DH4 , Q2TA69, Q53QE0, Q53SE1, Q96NM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	March 20, 2007
Last modified:	April 3, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.