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Protein

Raftlin-2

Gene

RFTN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Raftlin-2
Alternative name(s):
Raft-linking protein 2
Gene namesi
Name:RFTN2
Synonyms:C2orf11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26402. RFTN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162944.
PharmGKBiPA162401231.

Polymorphism and mutation databases

BioMutaiRFTN2.
DMDMi134047878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000893382 – 501Raftlin-2Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei409PhosphothreonineBy similarity1
Modified residuei430PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ52LD8.
PaxDbiQ52LD8.
PeptideAtlasiQ52LD8.
PRIDEiQ52LD8.

PTM databases

iPTMnetiQ52LD8.
PhosphoSitePlusiQ52LD8.

Expressioni

Gene expression databases

BgeeiENSG00000162944.
CleanExiHS_RFTN2.
ExpressionAtlasiQ52LD8. baseline and differential.
GenevisibleiQ52LD8. HS.

Organism-specific databases

HPAiHPA035232.

Interactioni

Protein-protein interaction databases

BioGridi126225. 7 interactors.
IntActiQ52LD8. 2 interactors.
STRINGi9606.ENSP00000295049.

Structurei

3D structure databases

ProteinModelPortaliQ52LD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the raftlin family.Curated

Phylogenomic databases

eggNOGiENOG410IH0B. Eukaryota.
ENOG410YAW3. LUCA.
GeneTreeiENSGT00530000063609.
HOGENOMiHOG000121785.
HOVERGENiHBG054056.
InParanoidiQ52LD8.
OMAiYTVFNVF.
OrthoDBiEOG091G07W6.
PhylomeDBiQ52LD8.
TreeFamiTF333285.

Family and domain databases

InterProiIPR028169. Raftlin.
[Graphical view]
PfamiPF15250. Raftlin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52LD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN
60 70 80 90 100
PEVIKINSIL DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV
110 120 130 140 150
VLLRLKLSPK NSAAPSGQRR PRLVIEECPL TSEAQTNDAA KELIEKINVA
160 170 180 190 200
AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI ESMLHVRHGS DENCRSWNEG
210 220 230 240 250
TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA SDNKLYTVFN
260 270 280 290 300
AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID
310 320 330 340 350
SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE
360 370 380 390 400
GCEIKTDYGP LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP
410 420 430 440 450
VMWNSAAQTP DKKASRHIKG EDKNKATSRS IGLDTTSSQP AESRHLPEEC
460 470 480 490 500
RLSPSRECWT KEGRLAQHNS FSGFSSSDNV LRELDDGQFD QEDGVTQVTC

M
Length:501
Mass (Da):55,922
Last modified:March 20, 2007 - v3
Checksum:i8DABA620EDE03E75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416R → H in BAB70861 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055136 mRNA. Translation: BAB70861.1.
AC020550 Genomic DNA. Translation: AAX93148.1.
AC114800 Genomic DNA. Translation: AAY24079.1.
CH471063 Genomic DNA. Translation: EAW70169.1.
BC093966 mRNA. Translation: AAH93966.1.
BC111069 mRNA. Translation: AAI11070.1.
BC113361 mRNA. Translation: AAI13362.1.
CCDSiCCDS2323.1.
RefSeqiNP_653230.2. NM_144629.2.
UniGeneiHs.591615.

Genome annotation databases

EnsembliENST00000295049; ENSP00000295049; ENSG00000162944.
GeneIDi130132.
KEGGihsa:130132.
UCSCiuc002uuo.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055136 mRNA. Translation: BAB70861.1.
AC020550 Genomic DNA. Translation: AAX93148.1.
AC114800 Genomic DNA. Translation: AAY24079.1.
CH471063 Genomic DNA. Translation: EAW70169.1.
BC093966 mRNA. Translation: AAH93966.1.
BC111069 mRNA. Translation: AAI11070.1.
BC113361 mRNA. Translation: AAI13362.1.
CCDSiCCDS2323.1.
RefSeqiNP_653230.2. NM_144629.2.
UniGeneiHs.591615.

3D structure databases

ProteinModelPortaliQ52LD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126225. 7 interactors.
IntActiQ52LD8. 2 interactors.
STRINGi9606.ENSP00000295049.

PTM databases

iPTMnetiQ52LD8.
PhosphoSitePlusiQ52LD8.

Polymorphism and mutation databases

BioMutaiRFTN2.
DMDMi134047878.

Proteomic databases

MaxQBiQ52LD8.
PaxDbiQ52LD8.
PeptideAtlasiQ52LD8.
PRIDEiQ52LD8.

Protocols and materials databases

DNASUi130132.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295049; ENSP00000295049; ENSG00000162944.
GeneIDi130132.
KEGGihsa:130132.
UCSCiuc002uuo.5. human.

Organism-specific databases

CTDi130132.
GeneCardsiRFTN2.
H-InvDBHIX0002711.
HGNCiHGNC:26402. RFTN2.
HPAiHPA035232.
neXtProtiNX_Q52LD8.
OpenTargetsiENSG00000162944.
PharmGKBiPA162401231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH0B. Eukaryota.
ENOG410YAW3. LUCA.
GeneTreeiENSGT00530000063609.
HOGENOMiHOG000121785.
HOVERGENiHBG054056.
InParanoidiQ52LD8.
OMAiYTVFNVF.
OrthoDBiEOG091G07W6.
PhylomeDBiQ52LD8.
TreeFamiTF333285.

Miscellaneous databases

ChiTaRSiRFTN2. human.
GenomeRNAii130132.
PROiQ52LD8.

Gene expression databases

BgeeiENSG00000162944.
CleanExiHS_RFTN2.
ExpressionAtlasiQ52LD8. baseline and differential.
GenevisibleiQ52LD8. HS.

Family and domain databases

InterProiIPR028169. Raftlin.
[Graphical view]
PfamiPF15250. Raftlin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFTN2_HUMAN
AccessioniPrimary (citable) accession number: Q52LD8
Secondary accession number(s): Q14DH4
, Q2TA69, Q53QE0, Q53SE1, Q96NM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.