Reviewed, UniProtKB/Swiss-Prot Q52LC2 (VAS1L_HUMAN)

Names and origin

Protein names

Recommended name:
    V-type proton ATPase subunit S1-like protein
Alternative name(s):
    Vacuolar proton pump subunit S1-like protein

Gene names

Name:

ATP6AP1L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the vacuolar ATPase subunit S1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting V-type ATPase, V1 domain Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	V-type proton ATPase subunit S1-like protein		PRO_0000342377
Regions
	Transmembrane	147 – 167	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q52LC2-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 65C104B815443678	FASTA	224	25,310
	10 20 30 40 50 60 MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY NKLSIQSWFS 70 80 90 100 110 120 LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD QALLLPSDTD DGSSLWEVTF 130 140 150 160 170 180 IDFQIQGFAI KGGRFTKAQD CASSFSPAFL IGLAMSLILL LVLAYALHML IYLRYLDQQY 190 200 210 220 DLIASPAHFS QLKARDTAEE KELLRSQGAE CYKLRSQQIS KIYV

References

[1]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH471084 Genomic DNA. Translation: EAW95889.1. BC093982 mRNA. Translation: AAH93982.1. BC112191 mRNA. Translation: AAI12192.1.
IPI	IPI00015115.
RefSeq	NP_001017971.1.
UniGene	Hs.364045
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q52LC2.
Genome annotation databases
Ensembl	ENST00000380167; ENSP00000369513; ENSG00000205464; Homo sapiens. [Genome view] ENST00000439350; ENSP00000391381; ENSG00000205464; Homo sapiens. [Genome view]
GeneID	92270.
KEGG	hsa:92270.
UCSC	uc003khv.1. human.
Organism-specific databases
CTD	92270.
GeneCards	GC05P081611.
HGNC	HGNC:28091. ATP6AP1L.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q52LC2.
OMA	YELRSQQ
OrthoDB	EOG98D3F2
Gene expression databases
ArrayExpress	Q52LC2.
Bgee	Q52LC2.
Genevestigator	Q52LC2.
Family and domain databases
InterPro	IPR008388. ATPase_V1-cplx_s1su. [Graphical view]
PANTHER	PTHR12471. ATPase_V1_S1. 1 hit.
Pfam	PF05827. ATP-synt_S1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	77659.

Entry information

Entry name

VAS1L_HUMAN

Accession

Primary (citable) accession number: Q52LC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.