Q52LC2 (VAS1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit S1-like protein

Alternative name(s):
Vacuolar proton pump subunit S1-like protein

Gene names

Name:

ATP6AP1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the vacuolar ATPase subunit S1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting V-type ATPase, V1 domain Inferred from electronic annotation. Source: InterPro
Molecular_function	proton-transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	V-type proton ATPase subunit S1-like protein		PRO_0000342377
Regions
	Transmembrane	147 – 167	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q52LC2 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 65C104B815443678	FASTA	224	25,310
	10 20 30 40 50 60 MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY NKLSIQSWFS 70 80 90 100 110 120 LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD QALLLPSDTD DGSSLWEVTF 130 140 150 160 170 180 IDFQIQGFAI KGGRFTKAQD CASSFSPAFL IGLAMSLILL LVLAYALHML IYLRYLDQQY 190 200 210 220 DLIASPAHFS QLKARDTAEE KELLRSQGAE CYKLRSQQIS KIYV

References

[1]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471084 Genomic DNA. Translation: EAW95889.1. BC093982 mRNA. Translation: AAH93982.1. BC112191 mRNA. Translation: AAI12192.1.
IPI	IPI00015115.
RefSeq	NP_001017971.1. NM_001017971.1.
UniGene	Hs.729805.
3D structure databases
ProteinModelPortal	Q52LC2.
ModBase	Search...
PTM databases
PhosphoSite	Q52LC2.
Polymorphism databases
DMDM	74735800.
Proteomic databases
PaxDb	Q52LC2.
PRIDE	Q52LC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380167; ENSP00000369513; ENSG00000205464. ENST00000439350; ENSP00000391381; ENSG00000205464.
GeneID	92270.
KEGG	hsa:92270.
UCSC	uc003khv.3. human.
Organism-specific databases
CTD	92270.
GeneCards	GC05P081612.
HGNC	HGNC:28091. ATP6AP1L.
HPA	HPA053771.
neXtProt	NX_Q52LC2.
PharmGKB	PA164716384.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG248409.
HOGENOM	HOG000154807.
InParanoid	Q52LC2.
OMA	YELRSQQ.
OrthoDB	EOG4Z0B6W.
Gene expression databases
Bgee	Q52LC2.
Genevestigator	Q52LC2.
Family and domain databases
InterPro	IPR008388. ATPase_V1-cplx_s1su. [Graphical view]
PANTHER	PTHR12471. PTHR12471. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	92270.
NextBio	77659.

Entry information

Entry name

VAS1L_HUMAN

Accession

Primary (citable) accession number: Q52LC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.