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Protein

V-type proton ATPase subunit S1-like protein

Gene

ATP6AP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
  2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit S1-like protein
Alternative name(s):
Vacuolar proton pump subunit S1-like protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:28091. ATP6AP1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. proton-transporting V-type ATPase, V1 domain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224V-type proton ATPase subunit S1-like proteinPRO_0000342377Add
BLAST

Proteomic databases

PaxDbiQ52LC2.
PRIDEiQ52LC2.

PTM databases

PhosphoSiteiQ52LC2.

Expressioni

Gene expression databases

BgeeiQ52LC2.
ExpressionAtlasiQ52LC2. baseline and differential.
GenevestigatoriQ52LC2.

Organism-specific databases

HPAiHPA053771.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369513.

Structurei

3D structure databases

ProteinModelPortaliQ52LC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vacuolar ATPase subunit S1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248409.
GeneTreeiENSGT00530000063584.
HOGENOMiHOG000154807.
InParanoidiQ52LC2.
OMAiQIQGFAI.
OrthoDBiEOG75TMBV.
PhylomeDBiQ52LC2.
TreeFamiTF325819.

Family and domain databases

InterProiIPR008388. ATPase_V1-cplx_s1su.
[Graphical view]
PANTHERiPTHR12471. PTHR12471. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52LC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY
60 70 80 90 100
NKLSIQSWFS LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD
110 120 130 140 150
QALLLPSDTD DGSSLWEVTF IDFQIQGFAI KGGRFTKAQD CASSFSPAFL
160 170 180 190 200
IGLAMSLILL LVLAYALHML IYLRYLDQQY DLIASPAHFS QLKARDTAEE
210 220
KELLRSQGAE CYKLRSQQIS KIYV
Length:224
Mass (Da):25,310
Last modified:May 24, 2005 - v1
Checksum:i65C104B815443678
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471084 Genomic DNA. Translation: EAW95889.1.
BC093982 mRNA. Translation: AAH93982.1.
BC112191 mRNA. Translation: AAI12192.1.
CCDSiCCDS34196.1.
RefSeqiNP_001017971.1. NM_001017971.2.
UniGeneiHs.729805.

Genome annotation databases

EnsembliENST00000380167; ENSP00000369513; ENSG00000205464.
ENST00000439350; ENSP00000391381; ENSG00000205464.
GeneIDi92270.
KEGGihsa:92270.
UCSCiuc003khv.3. human.

Polymorphism databases

DMDMi74735800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471084 Genomic DNA. Translation: EAW95889.1.
BC093982 mRNA. Translation: AAH93982.1.
BC112191 mRNA. Translation: AAI12192.1.
CCDSiCCDS34196.1.
RefSeqiNP_001017971.1. NM_001017971.2.
UniGeneiHs.729805.

3D structure databases

ProteinModelPortaliQ52LC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369513.

PTM databases

PhosphoSiteiQ52LC2.

Polymorphism databases

DMDMi74735800.

Proteomic databases

PaxDbiQ52LC2.
PRIDEiQ52LC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380167; ENSP00000369513; ENSG00000205464.
ENST00000439350; ENSP00000391381; ENSG00000205464.
GeneIDi92270.
KEGGihsa:92270.
UCSCiuc003khv.3. human.

Organism-specific databases

CTDi92270.
GeneCardsiGC05P081612.
HGNCiHGNC:28091. ATP6AP1L.
HPAiHPA053771.
neXtProtiNX_Q52LC2.
PharmGKBiPA164716384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG248409.
GeneTreeiENSGT00530000063584.
HOGENOMiHOG000154807.
InParanoidiQ52LC2.
OMAiQIQGFAI.
OrthoDBiEOG75TMBV.
PhylomeDBiQ52LC2.
TreeFamiTF325819.

Miscellaneous databases

GenomeRNAii92270.
NextBioi77659.
PROiQ52LC2.

Gene expression databases

BgeeiQ52LC2.
ExpressionAtlasiQ52LC2. baseline and differential.
GenevestigatoriQ52LC2.

Family and domain databases

InterProiIPR008388. ATPase_V1-cplx_s1su.
[Graphical view]
PANTHERiPTHR12471. PTHR12471. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiVAS1L_HUMAN
AccessioniPrimary (citable) accession number: Q52LC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.