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Q52LC2

- VAS1L_HUMAN

UniProt

Q52LC2 - VAS1L_HUMAN

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Protein

V-type proton ATPase subunit S1-like protein

Gene

ATP6AP1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
  2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit S1-like protein
Alternative name(s):
Vacuolar proton pump subunit S1-like protein
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:28091. ATP6AP1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. proton-transporting V-type ATPase, V1 domain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224V-type proton ATPase subunit S1-like proteinPRO_0000342377Add
BLAST

Proteomic databases

PaxDbiQ52LC2.
PRIDEiQ52LC2.

PTM databases

PhosphoSiteiQ52LC2.

Expressioni

Gene expression databases

BgeeiQ52LC2.
GenevestigatoriQ52LC2.

Organism-specific databases

HPAiHPA053771.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369513.

Structurei

3D structure databases

ProteinModelPortaliQ52LC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vacuolar ATPase subunit S1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248409.
GeneTreeiENSGT00530000063584.
HOGENOMiHOG000154807.
InParanoidiQ52LC2.
OMAiQIQGFAI.
OrthoDBiEOG75TMBV.
PhylomeDBiQ52LC2.
TreeFamiTF325819.

Family and domain databases

InterProiIPR008388. ATPase_V1-cplx_s1su.
[Graphical view]
PANTHERiPTHR12471. PTHR12471. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52LC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY
60 70 80 90 100
NKLSIQSWFS LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD
110 120 130 140 150
QALLLPSDTD DGSSLWEVTF IDFQIQGFAI KGGRFTKAQD CASSFSPAFL
160 170 180 190 200
IGLAMSLILL LVLAYALHML IYLRYLDQQY DLIASPAHFS QLKARDTAEE
210 220
KELLRSQGAE CYKLRSQQIS KIYV
Length:224
Mass (Da):25,310
Last modified:May 24, 2005 - v1
Checksum:i65C104B815443678
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471084 Genomic DNA. Translation: EAW95889.1.
BC093982 mRNA. Translation: AAH93982.1.
BC112191 mRNA. Translation: AAI12192.1.
CCDSiCCDS34196.1.
RefSeqiNP_001017971.1. NM_001017971.2.
UniGeneiHs.729805.

Genome annotation databases

EnsembliENST00000380167; ENSP00000369513; ENSG00000205464.
ENST00000439350; ENSP00000391381; ENSG00000205464.
GeneIDi92270.
KEGGihsa:92270.
UCSCiuc003khv.3. human.

Polymorphism databases

DMDMi74735800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471084 Genomic DNA. Translation: EAW95889.1 .
BC093982 mRNA. Translation: AAH93982.1 .
BC112191 mRNA. Translation: AAI12192.1 .
CCDSi CCDS34196.1.
RefSeqi NP_001017971.1. NM_001017971.2.
UniGenei Hs.729805.

3D structure databases

ProteinModelPortali Q52LC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369513.

PTM databases

PhosphoSitei Q52LC2.

Polymorphism databases

DMDMi 74735800.

Proteomic databases

PaxDbi Q52LC2.
PRIDEi Q52LC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380167 ; ENSP00000369513 ; ENSG00000205464 .
ENST00000439350 ; ENSP00000391381 ; ENSG00000205464 .
GeneIDi 92270.
KEGGi hsa:92270.
UCSCi uc003khv.3. human.

Organism-specific databases

CTDi 92270.
GeneCardsi GC05P081612.
HGNCi HGNC:28091. ATP6AP1L.
HPAi HPA053771.
neXtProti NX_Q52LC2.
PharmGKBi PA164716384.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248409.
GeneTreei ENSGT00530000063584.
HOGENOMi HOG000154807.
InParanoidi Q52LC2.
OMAi QIQGFAI.
OrthoDBi EOG75TMBV.
PhylomeDBi Q52LC2.
TreeFami TF325819.

Miscellaneous databases

GenomeRNAii 92270.
NextBioi 77659.
PROi Q52LC2.

Gene expression databases

Bgeei Q52LC2.
Genevestigatori Q52LC2.

Family and domain databases

InterProi IPR008388. ATPase_V1-cplx_s1su.
[Graphical view ]
PANTHERi PTHR12471. PTHR12471. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiVAS1L_HUMAN
AccessioniPrimary (citable) accession number: Q52LC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3