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Q52LC2

- VAS1L_HUMAN

UniProt

Q52LC2 - VAS1L_HUMAN

Protein

V-type proton ATPase subunit S1-like protein

Gene

ATP6AP1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
    2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit S1-like protein
    Alternative name(s):
    Vacuolar proton pump subunit S1-like protein
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:28091. ATP6AP1L.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. proton-transporting V-type ATPase, V1 domain Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164716384.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224V-type proton ATPase subunit S1-like proteinPRO_0000342377Add
    BLAST

    Proteomic databases

    PaxDbiQ52LC2.
    PRIDEiQ52LC2.

    PTM databases

    PhosphoSiteiQ52LC2.

    Expressioni

    Gene expression databases

    BgeeiQ52LC2.
    GenevestigatoriQ52LC2.

    Organism-specific databases

    HPAiHPA053771.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369513.

    Structurei

    3D structure databases

    ProteinModelPortaliQ52LC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vacuolar ATPase subunit S1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG248409.
    HOGENOMiHOG000154807.
    InParanoidiQ52LC2.
    OMAiQIQGFAI.
    OrthoDBiEOG75TMBV.
    PhylomeDBiQ52LC2.
    TreeFamiTF325819.

    Family and domain databases

    InterProiIPR008388. ATPase_V1-cplx_s1su.
    [Graphical view]
    PANTHERiPTHR12471. PTHR12471. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q52LC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY    50
    NKLSIQSWFS LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD 100
    QALLLPSDTD DGSSLWEVTF IDFQIQGFAI KGGRFTKAQD CASSFSPAFL 150
    IGLAMSLILL LVLAYALHML IYLRYLDQQY DLIASPAHFS QLKARDTAEE 200
    KELLRSQGAE CYKLRSQQIS KIYV 224
    Length:224
    Mass (Da):25,310
    Last modified:May 24, 2005 - v1
    Checksum:i65C104B815443678
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471084 Genomic DNA. Translation: EAW95889.1.
    BC093982 mRNA. Translation: AAH93982.1.
    BC112191 mRNA. Translation: AAI12192.1.
    CCDSiCCDS34196.1.
    RefSeqiNP_001017971.1. NM_001017971.1.
    UniGeneiHs.729805.

    Genome annotation databases

    EnsembliENST00000380167; ENSP00000369513; ENSG00000205464.
    ENST00000439350; ENSP00000391381; ENSG00000205464.
    GeneIDi92270.
    KEGGihsa:92270.
    UCSCiuc003khv.3. human.

    Polymorphism databases

    DMDMi74735800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471084 Genomic DNA. Translation: EAW95889.1 .
    BC093982 mRNA. Translation: AAH93982.1 .
    BC112191 mRNA. Translation: AAI12192.1 .
    CCDSi CCDS34196.1.
    RefSeqi NP_001017971.1. NM_001017971.1.
    UniGenei Hs.729805.

    3D structure databases

    ProteinModelPortali Q52LC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369513.

    PTM databases

    PhosphoSitei Q52LC2.

    Polymorphism databases

    DMDMi 74735800.

    Proteomic databases

    PaxDbi Q52LC2.
    PRIDEi Q52LC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380167 ; ENSP00000369513 ; ENSG00000205464 .
    ENST00000439350 ; ENSP00000391381 ; ENSG00000205464 .
    GeneIDi 92270.
    KEGGi hsa:92270.
    UCSCi uc003khv.3. human.

    Organism-specific databases

    CTDi 92270.
    GeneCardsi GC05P081612.
    HGNCi HGNC:28091. ATP6AP1L.
    HPAi HPA053771.
    neXtProti NX_Q52LC2.
    PharmGKBi PA164716384.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248409.
    HOGENOMi HOG000154807.
    InParanoidi Q52LC2.
    OMAi QIQGFAI.
    OrthoDBi EOG75TMBV.
    PhylomeDBi Q52LC2.
    TreeFami TF325819.

    Miscellaneous databases

    GenomeRNAii 92270.
    NextBioi 77659.
    PROi Q52LC2.

    Gene expression databases

    Bgeei Q52LC2.
    Genevestigatori Q52LC2.

    Family and domain databases

    InterProi IPR008388. ATPase_V1-cplx_s1su.
    [Graphical view ]
    PANTHERi PTHR12471. PTHR12471. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiVAS1L_HUMAN
    AccessioniPrimary (citable) accession number: Q52LC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3