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Protein

Protein lin-52 homolog

Gene

LIN52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1362277. Transcription of E2F targets under negative control by DREAM complex.
R-HSA-1362300. Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.
R-HSA-1538133. G0 and Early G1.
R-HSA-156711. Polo-like kinase mediated events.
R-HSA-539107. Activation of E2F1 target genes at G1/S.
R-HSA-69202. Cyclin E associated events during G1/S transition.
R-HSA-69656. Cyclin A:Cdk2-associated events at S phase entry.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-52 homolog
Gene namesi
Name:LIN52
Synonyms:C14orf46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000205659.10.
HGNCiHGNC:19856. LIN52.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi91750.
OpenTargetsiENSG00000205659.
PharmGKBiPA162394039.

Polymorphism and mutation databases

BioMutaiLIN52.
DMDMi74754720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521541 – 116Protein lin-52 homologAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ52LA3.
MaxQBiQ52LA3.
PaxDbiQ52LA3.
PeptideAtlasiQ52LA3.
PRIDEiQ52LA3.

PTM databases

iPTMnetiQ52LA3.
PhosphoSitePlusiQ52LA3.

Expressioni

Gene expression databases

BgeeiENSG00000205659.
CleanExiHS_LIN52.
ExpressionAtlasiQ52LA3. baseline and differential.
GenevisibleiQ52LA3. HS.

Organism-specific databases

HPAiHPA000900.
HPA001777.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBL2Q089997EBI-1389456,EBI-971439

Protein-protein interaction databases

BioGridi124874. 9 interactors.
CORUMiQ52LA3.
IntActiQ52LA3. 8 interactors.
STRINGi9606.ENSP00000451812.

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 31Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YOOX-ray2.40X15-34[»]
ProteinModelPortaliQ52LA3.
SMRiQ52LA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lin-52 family.Curated

Phylogenomic databases

eggNOGiKOG4402. Eukaryota.
ENOG4111VPU. LUCA.
GeneTreeiENSGT00390000008402.
HOGENOMiHOG000006570.
HOVERGENiHBG081917.
InParanoidiQ52LA3.
KOiK21775.
OMAiDMLQEFG.
OrthoDBiEOG091G0WNJ.
PhylomeDBiQ52LA3.
TreeFamiTF320091.

Family and domain databases

InterProiView protein in InterPro
IPR018737. DREAM_LIN52.
PANTHERiPTHR31489. PTHR31489. 1 hit.
PfamiView protein in Pfam
PF10044. LIN52. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52LA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWKMASPTD GTDLEASLLS FEKLDRASPD LWPEQLPGVA EFAASFKSPI
60 70 80 90 100
TSSPPKWMAE IERDDIDMLK ELGSLTTANL MEKVRGLQNL AYQLGLDESR
110
EMTRGKFLNI LEKPKK
Length:116
Mass (Da):13,001
Last modified:May 24, 2005 - v1
Checksum:iF9D1F2CA524975D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094003 mRNA. Translation: AAH94003.1.
BC094005 mRNA. Translation: AAH94005.1.
CCDSiCCDS32120.1.
RefSeqiNP_001019845.1. NM_001024674.2.
UniGeneiHs.612866.

Genome annotation databases

EnsembliENST00000555028; ENSP00000451812; ENSG00000205659.
GeneIDi91750.
KEGGihsa:91750.
UCSCiuc001xpp.3. human.

Similar proteinsi

Entry informationi

Entry nameiLIN52_HUMAN
AccessioniPrimary (citable) accession number: Q52LA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families