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Q52LA3 (LIN52_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lin-52 homolog
Gene names
Name:LIN52
Synonyms:C14orf46
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Ref.2 Ref.3

Sequence similarities

Belongs to the lin-52 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116Protein lin-52 homolog
PRO_0000252154

Amino acid modifications

Modified residue281Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q52LA3 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: F9D1F2CA524975D0

FASTA11613,001
        10         20         30         40         50         60 
MGWKMASPTD GTDLEASLLS FEKLDRASPD LWPEQLPGVA EFAASFKSPI TSSPPKWMAE 

        70         80         90        100        110 
IERDDIDMLK ELGSLTTANL MEKVRGLQNL AYQLGLDESR EMTRGKFLNI LEKPKK 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Haenel F., Brehm A., Gaubatz S.
Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
[3]"Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.
Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC094003 mRNA. Translation: AAH94003.1.
BC094005 mRNA. Translation: AAH94005.1.
RefSeqNP_001019845.1. NM_001024674.2.
UniGeneHs.612866.

3D structure databases

ProteinModelPortalQ52LA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124874. 8 interactions.
IntActQ52LA3. 6 interactions.
STRING9606.ENSP00000370488.

PTM databases

PhosphoSiteQ52LA3.

Polymorphism databases

DMDM74754720.

Proteomic databases

PaxDbQ52LA3.
PRIDEQ52LA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000555028; ENSP00000451812; ENSG00000205659.
GeneID91750.
KEGGhsa:91750.
UCSCuc001xpp.2. human.

Organism-specific databases

CTD91750.
GeneCardsGC14P074551.
HGNCHGNC:19856. LIN52.
HPAHPA000900.
neXtProtNX_Q52LA3.
PharmGKBPA162394039.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283481.
HOGENOMHOG000006570.
HOVERGENHBG081917.
InParanoidQ52LA3.
OMAEESREMT.
OrthoDBEOG7SJD6W.
PhylomeDBQ52LA3.
TreeFamTF320091.

Enzyme and pathway databases

ReactomeREACT_115566. Cell Cycle.

Gene expression databases

ArrayExpressQ52LA3.
BgeeQ52LA3.
CleanExHS_LIN52.
GenevestigatorQ52LA3.

Family and domain databases

InterProIPR018737. DREAM_LIN52.
[Graphical view]
PANTHERPTHR31489. PTHR31489. 1 hit.
PfamPF10044. Ret_tiss. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi91750.
NextBio77435.
PROQ52LA3.

Entry information

Entry nameLIN52_HUMAN
AccessionPrimary (citable) accession number: Q52LA3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM