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Protein

Importin subunit alpha

Gene

Kpna2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alphaUniRule annotation
Gene namesi
Name:Kpna2Imported
ORF Names:mCG_2886Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ52L97.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018362.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ52L97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60IBBInterPro annotationAdd BLAST60
Repeati119 – 162ARMPROSITE-ProRule annotationAdd BLAST44
Repeati162 – 204ARMPROSITE-ProRule annotationAdd BLAST43
Repeati204 – 230ARMPROSITE-ProRule annotationAdd BLAST27
Repeati251 – 293ARMPROSITE-ProRule annotationAdd BLAST43
Repeati293 – 335ARMPROSITE-ProRule annotationAdd BLAST43
Repeati335 – 377ARMPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the importin alpha family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
HOVERGENiHBG001846.
KOiK15043.
OMAiDQTRCVI.
OrthoDBiEOG091G095Z.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
PfamiView protein in Pfam
PF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiView protein in SMART
SM00185. ARM. 8 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 6 hits.
PS51214. IBB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52L97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNENANLP AARLNRFKNK GKDSTEMRRR RIEVNVELRK AKKDEQMLKR
60 70 80 90 100
RNVSSFPDDA TSPLQENRNN QGTVNWSVED IVKGINSNNL ESQLQATQAA
110 120 130 140 150
RKLLSREKQP PIDNIIRAGL IPKFVSFLGK TDCSPIQFES AWALTNIASG
160 170 180 190 200
TSEQTKAVVD GGAIPAFISL LASPHAHISE QAVWALGNIA GDGSAFRDLV
210 220 230 240 250
IKHGAIDPLL ALLAVPDLST LACGYLRNLT WTLSNLCRNK NPAPPLDAVE
260 270 280 290 300
QILPTLVRLL HHNDPEVLAD SCWAISYLTD GPNERIEMVV KKGVVPQLVK
310 320 330 340 350
LLGATELPIV TPALRAIGNI VTGTDEQTQK VIDAGALAVF PSLLTNPKTN
360 370 380 390 400
IQKEATWTMS NITAGRQDQI QQVVNHGLVP FLVGVLSKAD FKTQKEAAWA
410 420 430 440 450
ITNYTSGGTV EQIVYLVHCG IIEPLMNLLS AKDTKIIQVI LDAISNIFQA
460 470 480 490 500
AEKLGETEKL SIMIEECGGL DKIEALQRHE NESVYKASLN LIEKYFSVEE
510 520
EEDQNVVPET TSEGFAFQVQ DGAPGTFNF
Length:529
Mass (Da):57,928
Last modified:May 24, 2005 - v1
Checksum:i19E64AA3E9C3C7B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094011 mRNA. Translation: AAH94011.1.
AK139850 mRNA. Translation: BAE24160.1.
AK147135 mRNA. Translation: BAE27705.1.
AK165577 mRNA. Translation: BAE38268.1.
AK166577 mRNA. Translation: BAE38866.1.
AK166790 mRNA. Translation: BAE39020.1.
AK166982 mRNA. Translation: BAE39164.1.
AK167551 mRNA. Translation: BAE39616.1.
AK169283 mRNA. Translation: BAE41041.1.
CH466558 Genomic DNA. Translation: EDL34317.1.
CH466558 Genomic DNA. Translation: EDL34318.1.
CH466558 Genomic DNA. Translation: EDL34319.1.
RefSeqiNP_034785.1. NM_010655.3.
UniGeneiMm.12508.
Mm.391577.
Mm.423000.

Genome annotation databases

GeneIDi16647.
KEGGimmu:16647.

Similar proteinsi

Entry informationi

Entry nameiQ52L97_MOUSE
AccessioniPrimary (citable) accession number: Q52L97
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)