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Q52L14 (BAP1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1

EC=3.4.19.12
Alternative name(s):
BRCA1-associated protein 1
Gene names
Name:bap1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly nuclear. Binds to chromatin By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618Ubiquitin carboxyl-terminal hydrolase BAP1
PRO_0000395820

Sites

Active site911Nucleophile By similarity
Active site1691Proton donor By similarity
Site1841Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q52L14 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: BCB4CEB2821644D9

FASTA61868,256
        10         20         30         40         50         60 
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCP GPVYGFIFLF KWIEERRSRR 

        70         80         90        100        110        120 
KVSTLLDDTS VMEDEVVNNM FFAHQLIPNS CATHALLSVL LNCGGVHLGP TLSRIKEFTK 

       130        140        150        160        170        180 
GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL 

       190        200        210        220        230        240 
FELDGLKVYP IDHGPWAEDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRLK 

       250        260        270        280        290        300 
YEGKLNILKM NRQTVLEALQ QLIRVTQPEL IQAQKSTDGQ STEETKSPAI KAPVSQESHR 

       310        320        330        340        350        360 
AHHGSHRSTT DLGAEPAGSL LRGPVLSAHN KSKPLPQNGG IVPAPASRLP AFLDNHNYAK 

       370        380        390        400        410        420 
SPMQEEEDLA AGVGRSRGVP PPAPDTDEEE EEETENVRRP LTPPGFKRRS SESLPPPPGP 

       430        440        450        460        470        480 
EPGVLAEKLK ETQRDLCSPL SIKTGAPTAP HSQPSPTPSN ESTDTASEIG SAFNSPLRSP 

       490        500        510        520        530        540 
LRSANPTRPS SPVTSHLSKV LFGEEEPLSR LDCVRYNRAV RELGPHISTG ILHLSKDGYL 

       550        560        570        580        590        600 
SPLSRLDTGK VSPKSHKAEE PRESPEPDSE RNRVTEAPQG EKFSPKELLA LLKCVEAEIS 

       610 
ASEACLREEL EKRKKIQD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC094108 mRNA. Translation: AAH94108.1.
RefSeqNP_001089388.1. NM_001095919.1.
UniGeneXl.11445.

3D structure databases

ProteinModelPortalQ52L14.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID734438.
KEGGxla:734438.

Organism-specific databases

CTD8314.
XenbaseXB-GENE-866405. bap1.

Phylogenomic databases

HOVERGENHBG054042.
KOK08588.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Entry information

Entry nameBAP1_XENLA
AccessionPrimary (citable) accession number: Q52L14
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries