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Q52L14

- BAP1_XENLA

UniProt

Q52L14 - BAP1_XENLA

Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

bap1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911NucleophileBy similarity
    Active sitei169 – 1691Proton donorBy similarity
    Sitei184 – 1841Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. protein K48-linked deubiquitination Source: UniProtKB
    4. regulation of cell cycle Source: UniProtKB
    5. regulation of cell growth Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
    Alternative name(s):
    BRCA1-associated protein 1
    Gene namesi
    Name:bap1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-866405. bap1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly nuclear. Binds to chromatin By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395820Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ52L14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    HOVERGENiHBG054042.
    KOiK08588.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    Q52L14-1 [UniParc]FASTAAdd to Basket

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    MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCP GPVYGFIFLF    50
    KWIEERRSRR KVSTLLDDTS VMEDEVVNNM FFAHQLIPNS CATHALLSVL 100
    LNCGGVHLGP TLSRIKEFTK GFSPESKGYA IGNAPELAKA HNSHARPEPR 150
    HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWAEDE 200
    EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRLK YEGKLNILKM 250
    NRQTVLEALQ QLIRVTQPEL IQAQKSTDGQ STEETKSPAI KAPVSQESHR 300
    AHHGSHRSTT DLGAEPAGSL LRGPVLSAHN KSKPLPQNGG IVPAPASRLP 350
    AFLDNHNYAK SPMQEEEDLA AGVGRSRGVP PPAPDTDEEE EEETENVRRP 400
    LTPPGFKRRS SESLPPPPGP EPGVLAEKLK ETQRDLCSPL SIKTGAPTAP 450
    HSQPSPTPSN ESTDTASEIG SAFNSPLRSP LRSANPTRPS SPVTSHLSKV 500
    LFGEEEPLSR LDCVRYNRAV RELGPHISTG ILHLSKDGYL SPLSRLDTGK 550
    VSPKSHKAEE PRESPEPDSE RNRVTEAPQG EKFSPKELLA LLKCVEAEIS 600
    ASEACLREEL EKRKKIQD 618
    Length:618
    Mass (Da):68,256
    Last modified:May 24, 2005 - v1
    Checksum:iBCB4CEB2821644D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC094108 mRNA. Translation: AAH94108.1.
    RefSeqiNP_001089388.1. NM_001095919.1.
    UniGeneiXl.11445.

    Genome annotation databases

    GeneIDi734438.
    KEGGixla:734438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC094108 mRNA. Translation: AAH94108.1 .
    RefSeqi NP_001089388.1. NM_001095919.1.
    UniGenei Xl.11445.

    3D structure databases

    ProteinModelPortali Q52L14.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 734438.
    KEGGi xla:734438.

    Organism-specific databases

    CTDi 8314.
    Xenbasei XB-GENE-866405. bap1.

    Phylogenomic databases

    HOVERGENi HBG054042.
    KOi K08588.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiBAP1_XENLA
    AccessioniPrimary (citable) accession number: Q52L14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3