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Q52L14

- BAP1_XENLA

UniProt

Q52L14 - BAP1_XENLA

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Protein
Ubiquitin carboxyl-terminal hydrolase BAP1
Gene
bap1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911Nucleophile By similarity
Active sitei169 – 1691Proton donor By similarity
Sitei184 – 1841Important for enzyme activity By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB
  3. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  2. protein K48-linked deubiquitination Source: UniProtKB
  3. protein deubiquitination Source: UniProtKB
  4. regulation of cell cycle Source: UniProtKB
  5. regulation of cell growth Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
Alternative name(s):
BRCA1-associated protein 1
Gene namesi
Name:bap1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866405. bap1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Mainly nuclear. Binds to chromatin By similarity.

GO - Cellular componenti

  1. PR-DUB complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Ubiquitin carboxyl-terminal hydrolase BAP1
PRO_0000395820Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ52L14.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG054042.
KOiK08588.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q52L14-1 [UniParc]FASTAAdd to Basket

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MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCP GPVYGFIFLF    50
KWIEERRSRR KVSTLLDDTS VMEDEVVNNM FFAHQLIPNS CATHALLSVL 100
LNCGGVHLGP TLSRIKEFTK GFSPESKGYA IGNAPELAKA HNSHARPEPR 150
HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWAEDE 200
EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRLK YEGKLNILKM 250
NRQTVLEALQ QLIRVTQPEL IQAQKSTDGQ STEETKSPAI KAPVSQESHR 300
AHHGSHRSTT DLGAEPAGSL LRGPVLSAHN KSKPLPQNGG IVPAPASRLP 350
AFLDNHNYAK SPMQEEEDLA AGVGRSRGVP PPAPDTDEEE EEETENVRRP 400
LTPPGFKRRS SESLPPPPGP EPGVLAEKLK ETQRDLCSPL SIKTGAPTAP 450
HSQPSPTPSN ESTDTASEIG SAFNSPLRSP LRSANPTRPS SPVTSHLSKV 500
LFGEEEPLSR LDCVRYNRAV RELGPHISTG ILHLSKDGYL SPLSRLDTGK 550
VSPKSHKAEE PRESPEPDSE RNRVTEAPQG EKFSPKELLA LLKCVEAEIS 600
ASEACLREEL EKRKKIQD 618
Length:618
Mass (Da):68,256
Last modified:May 24, 2005 - v1
Checksum:iBCB4CEB2821644D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC094108 mRNA. Translation: AAH94108.1.
RefSeqiNP_001089388.1. NM_001095919.1.
UniGeneiXl.11445.

Genome annotation databases

GeneIDi734438.
KEGGixla:734438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC094108 mRNA. Translation: AAH94108.1 .
RefSeqi NP_001089388.1. NM_001095919.1.
UniGenei Xl.11445.

3D structure databases

ProteinModelPortali Q52L14.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 734438.
KEGGi xla:734438.

Organism-specific databases

CTDi 8314.
Xenbasei XB-GENE-866405. bap1.

Phylogenomic databases

HOVERGENi HBG054042.
KOi K08588.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiBAP1_XENLA
AccessioniPrimary (citable) accession number: Q52L14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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