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Protein

H/ACA ribonucleoprotein complex non-core subunit NAF1

Gene

Naf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex non-core subunit NAF1
Gene namesi
Name:Naf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306802. Naf1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457H/ACA ribonucleoprotein complex non-core subunit NAF1PRO_0000315639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei280 – 2801PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ52KK4.
PRIDEiQ52KK4.

PTM databases

iPTMnetiQ52KK4.
PhosphoSiteiQ52KK4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000026403.

Interactioni

Subunit structurei

During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031163.

Structurei

3D structure databases

ProteinModelPortaliQ52KK4.
SMRiQ52KK4. Positions 146-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 7752Pro-richAdd
BLAST
Compositional biasi82 – 11332Ser-richAdd
BLAST
Compositional biasi354 – 44592Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the NAF1 family.Curated

Phylogenomic databases

eggNOGiKOG2236. Eukaryota.
ENOG4111RRE. LUCA.
HOGENOMiHOG000214085.
HOVERGENiHBG108169.
InParanoidiQ52KK4.
KOiK14763.
PhylomeDBiQ52KK4.

Family and domain databases

InterProiIPR007504. H/ACA_rnp_Gar1/Naf1.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF04410. Gar1. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52KK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVVEAAAQL QTLKFGGSGP GSAASPPPEE RPDAEQAEQA PPAGEQPPPA
60 70 80 90 100
PSSDAGENPP PPSGPCATAP DAAEPLPELQ DSDSSDSDSD SETDSDSSSS
110 120 130 140 150
SSSSSSSSSS CGSLPPVLSD GEEDVQVEKE NKNFPLKTKD ELLLNELPSV
160 170 180 190 200
EELTVTLPED IALKPLGKVS SIIEQLVIIE SMTNIPPVNE DTVIFKSDRQ
210 220 230 240 250
AAGKIFEIFG PVAHPFYVLR FNSSEHIESK GIKIKDTMYF APSMKDFTQY
260 270 280 290 300
IFTEKLKQDR GSDASWKNDQ EPPPEALDFS DDEKEKEAKQ RKKSQIQGRK
310 320 330 340 350
KLKSELNESG EDFGEVHQNW NANSSSEHSK GYHNREFTRG FPRGRYSRGS
360 370 380 390 400
HGRPPPQQYY NSDPMASQES LGFPPQRQDN PVMPHYPFPP PMFDMHNFPL
410 420 430 440 450
PPPPPPPPTV SMGWAAPSMT SHPVLNLPYS LPPPPLPPPP PPPSPGESNS

SHFGSYY
Length:457
Mass (Da):49,764
Last modified:May 24, 2005 - v1
Checksum:i08D131A43D54250D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094302 mRNA. Translation: AAH94302.1.
RefSeqiNP_001019943.1. NM_001024772.1.
UniGeneiRn.162269.

Genome annotation databases

GeneIDi306387.
KEGGirno:306387.
UCSCiRGD:1306802. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094302 mRNA. Translation: AAH94302.1.
RefSeqiNP_001019943.1. NM_001024772.1.
UniGeneiRn.162269.

3D structure databases

ProteinModelPortaliQ52KK4.
SMRiQ52KK4. Positions 146-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031163.

PTM databases

iPTMnetiQ52KK4.
PhosphoSiteiQ52KK4.

Proteomic databases

PaxDbiQ52KK4.
PRIDEiQ52KK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi306387.
KEGGirno:306387.
UCSCiRGD:1306802. rat.

Organism-specific databases

CTDi92345.
RGDi1306802. Naf1.

Phylogenomic databases

eggNOGiKOG2236. Eukaryota.
ENOG4111RRE. LUCA.
HOGENOMiHOG000214085.
HOVERGENiHBG108169.
InParanoidiQ52KK4.
KOiK14763.
PhylomeDBiQ52KK4.

Miscellaneous databases

PROiQ52KK4.

Gene expression databases

BgeeiENSRNOG00000026403.

Family and domain databases

InterProiIPR007504. H/ACA_rnp_Gar1/Naf1.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF04410. Gar1. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAF1_RAT
AccessioniPrimary (citable) accession number: Q52KK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.