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Protein

Methionine-R-sulfoxide reductase B1

Gene

Msrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.By similarity
L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi71ZincPROSITE-ProRule annotation1
Metal bindingi74ZincPROSITE-ProRule annotation1
Active sitei95NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B1 (EC:1.8.4.12By similarity, EC:1.8.4.14By similarity)
Short name:
MsrB1
Alternative name(s):
Selenoprotein X
Short name:
SelX
Gene namesi
Name:Msrb1
Synonyms:Sepx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1583243. Msrb1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3509600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003186121 – 116Methionine-R-sulfoxide reductase B1Add BLAST116

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106MsrBPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ52KJ8.
KOiK07305.
PhylomeDBiQ52KJ8.
TreeFamiTF329147.

Family and domain databases

InterProiView protein in InterPro
IPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like_sf.
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiView protein in Pfam
PF01641. SelR. 1 hit.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiView protein in PROSITE
PS51790. MSRB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52KJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI
60 70 80 90 100
HEDSVAKCPE KNRPEALKVS CGKCGNGLGH EFLNDGPKRG QSRFUIFSSS
110
LKFIPKGKEA PASQGD
Length:116
Mass (Da):12,797
Last modified:February 26, 2008 - v2
Checksum:i2CADD12D1C32CCC8
GO

Sequence cautioni

The sequence AAH94309 differs from that shown. Reason: Erroneous termination at position 95. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei95SelenocysteineBy similarity1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094309 mRNA. Translation: AAH94309.1. Sequence problems.
RefSeqiNP_001037750.2. NM_001044285.3.
UniGeneiRn.198860.

Genome annotation databases

GeneIDi685059.
KEGGirno:685059.
UCSCiRGD:1583243. rat.

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiMSRB1_RAT
AccessioniPrimary (citable) accession number: Q52KJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families