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Q52KG5

- KI26A_MOUSE

UniProt

Q52KG5 - KI26A_MOUSE

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Protein

Kinesin-like protein KIF26A

Gene

Kif26a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi462 – 4698ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule binding Source: UniProtKB

GO - Biological processi

  1. enteric nervous system development Source: UniProtKB
  2. negative regulation of signal transduction Source: UniProtKB
  3. regulation of cell growth by extracellular stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF26A
Gene namesi
Name:Kif26a
Synonyms:Kiaa1236
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2447072. Kif26a.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: RefGenome
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18811881Kinesin-like protein KIF26APRO_0000307300Add
BLAST

Proteomic databases

PRIDEiQ52KG5.

PTM databases

PhosphoSiteiQ52KG5.

Expressioni

Tissue specificityi

Expressed in several neuronal populations.1 Publication

Developmental stagei

Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at embryonic day 12.5 (E12.5), E14.5, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at E14.5.1 Publication

Gene expression databases

BgeeiQ52KG5.
CleanExiMM_KIF26A.
GenevestigatoriQ52KG5.

Interactioni

Subunit structurei

Interacts with GRB2 (via SH2 domain).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606312EBI-2480646,EBI-1688

Protein-protein interaction databases

IntActiQ52KG5. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ52KG5.
SMRiQ52KG5. Positions 365-721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini364 – 718355Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1780 – 181233Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00650000093360.
HOGENOMiHOG000081802.
HOVERGENiHBG108063.
InParanoidiQ52KG5.
KOiK10404.
OMAiHMSLERC.
OrthoDBiEOG7J445V.
PhylomeDBiQ52KG5.
TreeFamiTF105235.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52KG5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGRGASLCA VQPAVAECGP ARETPPLEVS PRKRLPAGLD QDPCSSRPAP
60 70 80 90 100
EGAGASAEQS HSAGGGGWCR HCHTKLVELK RQAWKLVSGP GTPLRDPCLS
110 120 130 140 150
TLLLDKLPAS GVQPACRPDT ESRCDVCTTH LHQLTREALR LLQTPASHED
160 170 180 190 200
PNASRGGLAA PSSRDPPGPV GLMGRQPPVG PDRRKATAWP PGPSVQVSVA
210 220 230 240 250
PAGLGGALST VTIQAQQCLE GVWSLSRVNS FLPPTCLAEA AVAAVAVADT
260 270 280 290 300
VRDCAPAAGP ERMSKAWGRG AACTTALVTP APGTSAGGST GPSAAASFFI
310 320 330 340 350
RAAQKLSLAS KRKKHHPPPA PSTRGTSTYP TDFSGSLQLW PPPVPPCLLR
360 370 380 390 400
AASKAKENPS SFGKVKVMLR IWPAQGVQRS AESTSFLKVD SRKKQVTLYD
410 420 430 440 450
PAAGPPGCAG LRHAPTAPVP KMFAFDAIFP QDSEQAEVCS GTVADVLQSV
460 470 480 490 500
VSGADGCIFS FGHMSLGKSY TMIGKDSSPQ SLGIVPCAIS WLFRLIDERK
510 520 530 540 550
ERLGTRFSIR VSAVEVCGHD QSLRDLLAEV ASGSLQDTQS PGVYLREDPV
560 570 580 590 600
CGTQLQNQNE LRAPTAEKAA FYLDAALAAR STSRAGCGEE ARRSSHMLFT
610 620 630 640 650
LHVYQYRVEK CGQGGMSGGR SRLHLIDLGS CDAAVGRGGE ASGGPLCLSL
660 670 680 690 700
SALGSVILAL VNGAKHVPYR DHRLTMLLRE SLATTNCRTT MIAHISDSPA
710 720 730 740 750
HHAETLSTVQ LAARIHRLRR KKGKHASSSS GGESSCEEGR ARRPPHLRPF
760 770 780 790 800
HPRAVVLDPD RSAPGLSGDP DYSSSSEQSC DTVIYVGPGG MALSDRELTD
810 820 830 840 850
NEGPPDFVPI IPALSRRRPS EGPRDADHFR CSTFAELQER LECIDGSEAF
860 870 880 890 900
PGPQGGSDGA QASPARGGRK PSLPEATPSR KAVAPTVVTS CPRGSPGHDT
910 920 930 940 950
HRSASDPSKT GTQSEQRVDG SRPEPPASDK TSGGGGRRPL PSPAPPPPRQ
960 970 980 990 1000
PEAQGIPKEP GGEGTDSVLR TPPVGMSGQA ALPPLLSDSA YLSPSARGRH
1010 1020 1030 1040 1050
LERGLLTTTV TLQQPVELNG EDELVFTVVE ELPLGGLAGA TRPSSLASMS
1060 1070 1080 1090 1100
SDCSLQALAS GSRPVSIISS INDEFDAYTS QMSEGPGDPG EFPEGTAWAG
1110 1120 1130 1140 1150
GSPASSIGSW LSDVGVCLSE SRGPTPQPPF SPNSAAGPGP PEFPTPGSSL
1160 1170 1180 1190 1200
EESKVRSSEC GRPDNPGSAR SLHPGEAVAT TQTQPGREPW ARSPHEVASA
1210 1220 1230 1240 1250
QTIHSSLPRK PRTTSTASRA RPSRGPYSPG GLFEDPWLLR AEDCDTRQIA
1260 1270 1280 1290 1300
STGRAPSPTP GSPRLPETQM MLACAQRVVD GCEVASRMSR RPEAVARIPP
1310 1320 1330 1340 1350
LRRGATTLGV TTPAASCGDA PAEAVVHSGS LKTTSGSKKS VSPKGAFFPR
1360 1370 1380 1390 1400
PSGAGPPAPP VRKSSLEQST ALTPTQALGL TRAGAPSAFR GEEEARPSGR
1410 1420 1430 1440 1450
SDSSVPKATS SLKARAGKMD VPYRPSGHMS LERCEGLAHG SSKVRDVVGR
1460 1470 1480 1490 1500
PPRAVPRLGV PSASPPLGPA PACRNSPAKG VGATKPPAGG AKGRNLGPST
1510 1520 1530 1540 1550
SRALGAPVKP LGPVAGKTAG GAVPGPRAAP RAVPGIGAKA GRGTIMGTKQ
1560 1570 1580 1590 1600
AFRAAHSRVH ELAASGSPSR GGLSWGSTDS DSGNDSGVNL AEERQPSSPA
1610 1620 1630 1640 1650
LPSPYSKVTA PRRPQRYSSG HGSDNSSVLS GELPPAMGRT ALFYHSGGSS
1660 1670 1680 1690 1700
GYESMIRDSE ATGSASSAPD SMSESGTASL GARSRSLKSP KKRATGLQRR
1710 1720 1730 1740 1750
RLIPAPLPDA AALGRKPSLP GQWVDLPPPL AGSLKEPFEI KVYEIDDVER
1760 1770 1780 1790 1800
LQRHRLPLRE NEAKPSQDAE KGPVCISSKL RLAERRQQRL QEVQAKRDHL
1810 1820 1830 1840 1850
CEELAETQGR LMVEPGRWLE QFEVDPELEP ESAEYLVALE QATAALEQCV
1860 1870 1880
NLCKAHVMMV TCFDIGVAAT TAVPGPQEVD V
Length:1,881
Mass (Da):196,313
Last modified:October 23, 2007 - v2
Checksum:i6A8B5235D7DB70D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201T → A in ACV92100. (PubMed:19914172)Curated
Sequence conflicti152 – 1521N → D in ACV92100. (PubMed:19914172)Curated
Sequence conflicti163 – 1631S → P in ACV92100. (PubMed:19914172)Curated
Sequence conflicti635 – 6351V → I in BAC98125. (PubMed:14621295)Curated
Sequence conflicti690 – 6901T → I in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1101 – 11011G → S in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1118 – 11181L → F in AAH94358. (PubMed:15489334)Curated
Sequence conflicti1200 – 12001A → V in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1312 – 13121T → S in ACV92100. (PubMed:19914172)Curated
Sequence conflicti1333 – 13331T → N in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1421 – 14211V → A in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1437 – 14371L → P in ACV92100. (PubMed:19914172)Curated
Sequence conflicti1518 – 15181T → TA in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1577 – 15771S → P in ACV92100. (PubMed:19914172)Curated
Sequence conflicti1769 – 17691A → V in BAC98125. (PubMed:14621295)Curated
Sequence conflicti1773 – 17731P → S in ACV92100. (PubMed:19914172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ489027 mRNA. Translation: ACV92100.1.
AC112520 Genomic DNA. No translation available.
AB054031 Genomic DNA. Translation: BAB32495.1.
AK129315 mRNA. Translation: BAC98125.1.
BC059062 mRNA. Translation: AAH59062.1.
BC094358 mRNA. Translation: AAH94358.1.
CCDSiCCDS49186.1.
RefSeqiNP_001091090.1. NM_001097621.1.
UniGeneiMm.313104.

Genome annotation databases

EnsembliENSMUST00000128402; ENSMUSP00000119482; ENSMUSG00000021294.
GeneIDi668303.
KEGGimmu:668303.
UCSCiuc007pem.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ489027 mRNA. Translation: ACV92100.1 .
AC112520 Genomic DNA. No translation available.
AB054031 Genomic DNA. Translation: BAB32495.1 .
AK129315 mRNA. Translation: BAC98125.1 .
BC059062 mRNA. Translation: AAH59062.1 .
BC094358 mRNA. Translation: AAH94358.1 .
CCDSi CCDS49186.1.
RefSeqi NP_001091090.1. NM_001097621.1.
UniGenei Mm.313104.

3D structure databases

ProteinModelPortali Q52KG5.
SMRi Q52KG5. Positions 365-721.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q52KG5. 2 interactions.

PTM databases

PhosphoSitei Q52KG5.

Proteomic databases

PRIDEi Q52KG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000128402 ; ENSMUSP00000119482 ; ENSMUSG00000021294 .
GeneIDi 668303.
KEGGi mmu:668303.
UCSCi uc007pem.1. mouse.

Organism-specific databases

CTDi 26153.
MGIi MGI:2447072. Kif26a.
Rougei Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00650000093360.
HOGENOMi HOG000081802.
HOVERGENi HBG108063.
InParanoidi Q52KG5.
KOi K10404.
OMAi HMSLERC.
OrthoDBi EOG7J445V.
PhylomeDBi Q52KG5.
TreeFami TF105235.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

ChiTaRSi KIF26A. mouse.
NextBioi 434531.
PROi Q52KG5.
SOURCEi Search...

Gene expression databases

Bgeei Q52KG5.
CleanExi MM_KIF26A.
Genevestigatori Q52KG5.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development."
    Zhou R., Niwa S., Homma N., Takei Y., Hirokawa N.
    Cell 139:802-813(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MICROTUBULE-BINDING, LACK OF ATPASE ACTIVITY, INTERACTION WITH GRB2.
    Strain: A/J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "All kinesin superfamily protein, KIF, genes in mouse and human."
    Miki H., Setou M., Kaneshiro K.
    Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-613.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-1881.
    Tissue: Embryonic tail.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1881.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiKI26A_MOUSE
AccessioniPrimary (citable) accession number: Q52KG5
Secondary accession number(s): C9EF47
, Q6PCY3, Q6ZPV4, Q99PT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3