Q52KG5 (KI26A_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 53.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Kinesin-like protein KIF26A | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 1881 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. Ref.1 |
| Subunit structure | Interacts with GRB2 (via SH2 domain). Ref.1 |
| Subcellular location | Cytoplasm › cytoskeleton Probable. |
| Tissue specificity | Expressed in several neuronal populations. Ref.1 |
| Developmental stage | Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at embryonic day 12.5 (E12.5), E14.5, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at E14.5. Ref.1 |
| Disruption phenotype | Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation. Ref.1 |
| Sequence similarities | Belongs to the kinesin-like protein family. KIF26 subfamily. Contains 1 kinesin-motor domain. |
| Caution | In contrast to other kinesin-like proteins, residues required for ATPase activity are missing. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton Microtubule |
| Domain | Coiled coil |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Motor protein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | enteric nervous system development Inferred from mutant phenotype Ref.1. Source: UniProtKB negative regulation of signal transductionInferred from mutant phenotype Ref.1. Source: UniProtKB regulation of cell growth by extracellular stimulusInferred from mutant phenotype Ref.1. Source: UniProtKB |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubuleInferred from electronic annotation. Source: UniProtKB-KW microtubule associated complexInferred from electronic annotation. Source: InterPro |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule bindingInferred from direct assay Ref.1. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Grb2 | Q60631 | 2 | EBI-2480646,EBI-1688 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1881 | 1881 | Kinesin-like protein KIF26A | PRO_0000307300 | |||||
Regions | |||||||||
| Domain | 361 – 654 | 294 | Kinesin-motor | ||||||
| Nucleotide binding | 462 – 469 | 8 | ATP Potential | ||||||
| Coiled coil | 1780 – 1812 | 33 | Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 120 | 1 | T → A in ACV92100. Ref.1 | ||||||
| Sequence conflict | 152 | 1 | N → D in ACV92100. Ref.1 | ||||||
| Sequence conflict | 163 | 1 | S → P in ACV92100. Ref.1 | ||||||
| Sequence conflict | 635 | 1 | V → I in BAC98125. Ref.4 | ||||||
| Sequence conflict | 690 | 1 | T → I in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1101 | 1 | G → S in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1118 | 1 | L → F in AAH94358. Ref.5 | ||||||
| Sequence conflict | 1200 | 1 | A → V in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1312 | 1 | T → S in ACV92100. Ref.1 | ||||||
| Sequence conflict | 1333 | 1 | T → N in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1421 | 1 | V → A in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1437 | 1 | L → P in ACV92100. Ref.1 | ||||||
| Sequence conflict | 1518 | 1 | T → TA in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1577 | 1 | S → P in ACV92100. Ref.1 | ||||||
| Sequence conflict | 1769 | 1 | A → V in BAC98125. Ref.4 | ||||||
| Sequence conflict | 1773 | 1 | P → S in ACV92100. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development." Zhou R., Niwa S., Homma N., Takei Y., Hirokawa N. Cell 139:802-813(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MICROTUBULE-BINDING, LACK OF ATPASE ACTIVITY, INTERACTION WITH GRB2. Strain: A/J. |
| [2] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.  Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [3] | "All kinesin superfamily protein, KIF, genes in mouse and human." Miki H., Setou M., Kaneshiro K. Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-613. |
| [4] | "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-1881. Tissue: Embryonic tail. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1881. Strain: C57BL/6. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | GQ489027 mRNA. Translation: ACV92100.1. AC112520 Genomic DNA. No translation available. AB054031 Genomic DNA. Translation: BAB32495.1. AK129315 mRNA. Translation: BAC98125.1. BC059062 mRNA. Translation: AAH59062.1. BC094358 mRNA. Translation: AAH94358.1. |
| IPI | IPI00420571. |
| RefSeq | NP_001091090.1. NM_001097621.1. |
| UniGene | Mm.313104. |
3D structure databases | |
| ProteinModelPortal | Q52KG5. |
| SMR | Q52KG5. Positions 365-721. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q52KG5. 2 interactions. |
PTM databases | |
| PhosphoSite | Q52KG5. |
Proteomic databases | |
| PRIDE | Q52KG5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000128402; ENSMUSP00000119482; ENSMUSG00000021294. |
| GeneID | 668303. |
| KEGG | mmu:668303. |
| UCSC | uc007pem.1. mouse. |
Organism-specific databases | |
| CTD | 26153. |
| MGI | MGI:2447072. Kif26a. |
| Rouge | Search... |
Phylogenomic databases | |
| eggNOG | COG5059. |
| GeneTree | ENSGT00650000093360. |
| HOGENOM | HOG000081802. |
| HOVERGEN | HBG108063. |
| InParanoid | Q52KG5. |
| KO | K10404. |
| OMA | HMSLERC. |
| OrthoDB | EOG4QVCB7. |
Gene expression databases | |
| Bgee | Q52KG5. |
| CleanEx | MM_KIF26A. |
| Genevestigator | Q52KG5. |
Family and domain databases | |
| Gene3D | 3.40.850.10. 1 hit. |
| InterPro | IPR001752. Kinesin_motor_dom. [Graphical view] |
| Pfam | PF00225. Kinesin. 1 hit. [Graphical view] |
| PRINTS | PR00380. KINESINHEAVY. |
| SMART | SM00129. KISc. 1 hit. [Graphical view] |
| PROSITE | PS00411. KINESIN_MOTOR_DOMAIN1. False negative. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | KIF26A. mouse. |
| NextBio | 434531. |
| SOURCE | Search... |
Entry information
| Entry name | KI26A_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q52KG5 Secondary accession number(s): C9EF47 Q99PT4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |