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Q52KG5

- KI26A_MOUSE

UniProt

Q52KG5 - KI26A_MOUSE

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Protein
Kinesin-like protein KIF26A
Gene
Kif26a, Kiaa1236
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi462 – 4698ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule binding Source: UniProtKB
  3. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. enteric nervous system development Source: UniProtKB
  2. negative regulation of signal transduction Source: UniProtKB
  3. regulation of cell growth by extracellular stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF26A
Gene namesi
Name:Kif26a
Synonyms:Kiaa1236
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2447072. Kif26a.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18811881Kinesin-like protein KIF26A
PRO_0000307300Add
BLAST

Proteomic databases

PRIDEiQ52KG5.

PTM databases

PhosphoSiteiQ52KG5.

Expressioni

Tissue specificityi

Expressed in several neuronal populations.1 Publication

Developmental stagei

Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at embryonic day 12.5 (E12.5), E14.5, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at E14.5.1 Publication

Gene expression databases

BgeeiQ52KG5.
CleanExiMM_KIF26A.
GenevestigatoriQ52KG5.

Interactioni

Subunit structurei

Interacts with GRB2 (via SH2 domain).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606312EBI-2480646,EBI-1688

Protein-protein interaction databases

IntActiQ52KG5. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ52KG5.
SMRiQ52KG5. Positions 365-721.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini364 – 718355Kinesin motor
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1780 – 181233 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00650000093360.
HOGENOMiHOG000081802.
HOVERGENiHBG108063.
InParanoidiQ52KG5.
KOiK10404.
OMAiHMSLERC.
OrthoDBiEOG7J445V.
PhylomeDBiQ52KG5.
TreeFamiTF105235.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52KG5-1 [UniParc]FASTAAdd to Basket

« Hide

MVGRGASLCA VQPAVAECGP ARETPPLEVS PRKRLPAGLD QDPCSSRPAP     50
EGAGASAEQS HSAGGGGWCR HCHTKLVELK RQAWKLVSGP GTPLRDPCLS 100
TLLLDKLPAS GVQPACRPDT ESRCDVCTTH LHQLTREALR LLQTPASHED 150
PNASRGGLAA PSSRDPPGPV GLMGRQPPVG PDRRKATAWP PGPSVQVSVA 200
PAGLGGALST VTIQAQQCLE GVWSLSRVNS FLPPTCLAEA AVAAVAVADT 250
VRDCAPAAGP ERMSKAWGRG AACTTALVTP APGTSAGGST GPSAAASFFI 300
RAAQKLSLAS KRKKHHPPPA PSTRGTSTYP TDFSGSLQLW PPPVPPCLLR 350
AASKAKENPS SFGKVKVMLR IWPAQGVQRS AESTSFLKVD SRKKQVTLYD 400
PAAGPPGCAG LRHAPTAPVP KMFAFDAIFP QDSEQAEVCS GTVADVLQSV 450
VSGADGCIFS FGHMSLGKSY TMIGKDSSPQ SLGIVPCAIS WLFRLIDERK 500
ERLGTRFSIR VSAVEVCGHD QSLRDLLAEV ASGSLQDTQS PGVYLREDPV 550
CGTQLQNQNE LRAPTAEKAA FYLDAALAAR STSRAGCGEE ARRSSHMLFT 600
LHVYQYRVEK CGQGGMSGGR SRLHLIDLGS CDAAVGRGGE ASGGPLCLSL 650
SALGSVILAL VNGAKHVPYR DHRLTMLLRE SLATTNCRTT MIAHISDSPA 700
HHAETLSTVQ LAARIHRLRR KKGKHASSSS GGESSCEEGR ARRPPHLRPF 750
HPRAVVLDPD RSAPGLSGDP DYSSSSEQSC DTVIYVGPGG MALSDRELTD 800
NEGPPDFVPI IPALSRRRPS EGPRDADHFR CSTFAELQER LECIDGSEAF 850
PGPQGGSDGA QASPARGGRK PSLPEATPSR KAVAPTVVTS CPRGSPGHDT 900
HRSASDPSKT GTQSEQRVDG SRPEPPASDK TSGGGGRRPL PSPAPPPPRQ 950
PEAQGIPKEP GGEGTDSVLR TPPVGMSGQA ALPPLLSDSA YLSPSARGRH 1000
LERGLLTTTV TLQQPVELNG EDELVFTVVE ELPLGGLAGA TRPSSLASMS 1050
SDCSLQALAS GSRPVSIISS INDEFDAYTS QMSEGPGDPG EFPEGTAWAG 1100
GSPASSIGSW LSDVGVCLSE SRGPTPQPPF SPNSAAGPGP PEFPTPGSSL 1150
EESKVRSSEC GRPDNPGSAR SLHPGEAVAT TQTQPGREPW ARSPHEVASA 1200
QTIHSSLPRK PRTTSTASRA RPSRGPYSPG GLFEDPWLLR AEDCDTRQIA 1250
STGRAPSPTP GSPRLPETQM MLACAQRVVD GCEVASRMSR RPEAVARIPP 1300
LRRGATTLGV TTPAASCGDA PAEAVVHSGS LKTTSGSKKS VSPKGAFFPR 1350
PSGAGPPAPP VRKSSLEQST ALTPTQALGL TRAGAPSAFR GEEEARPSGR 1400
SDSSVPKATS SLKARAGKMD VPYRPSGHMS LERCEGLAHG SSKVRDVVGR 1450
PPRAVPRLGV PSASPPLGPA PACRNSPAKG VGATKPPAGG AKGRNLGPST 1500
SRALGAPVKP LGPVAGKTAG GAVPGPRAAP RAVPGIGAKA GRGTIMGTKQ 1550
AFRAAHSRVH ELAASGSPSR GGLSWGSTDS DSGNDSGVNL AEERQPSSPA 1600
LPSPYSKVTA PRRPQRYSSG HGSDNSSVLS GELPPAMGRT ALFYHSGGSS 1650
GYESMIRDSE ATGSASSAPD SMSESGTASL GARSRSLKSP KKRATGLQRR 1700
RLIPAPLPDA AALGRKPSLP GQWVDLPPPL AGSLKEPFEI KVYEIDDVER 1750
LQRHRLPLRE NEAKPSQDAE KGPVCISSKL RLAERRQQRL QEVQAKRDHL 1800
CEELAETQGR LMVEPGRWLE QFEVDPELEP ESAEYLVALE QATAALEQCV 1850
NLCKAHVMMV TCFDIGVAAT TAVPGPQEVD V 1881
Length:1,881
Mass (Da):196,313
Last modified:October 23, 2007 - v2
Checksum:i6A8B5235D7DB70D2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201T → A in ACV92100. 1 Publication
Sequence conflicti152 – 1521N → D in ACV92100. 1 Publication
Sequence conflicti163 – 1631S → P in ACV92100. 1 Publication
Sequence conflicti635 – 6351V → I in BAC98125. 1 Publication
Sequence conflicti690 – 6901T → I in BAC98125. 1 Publication
Sequence conflicti1101 – 11011G → S in BAC98125. 1 Publication
Sequence conflicti1118 – 11181L → F in AAH94358. 1 Publication
Sequence conflicti1200 – 12001A → V in BAC98125. 1 Publication
Sequence conflicti1312 – 13121T → S in ACV92100. 1 Publication
Sequence conflicti1333 – 13331T → N in BAC98125. 1 Publication
Sequence conflicti1421 – 14211V → A in BAC98125. 1 Publication
Sequence conflicti1437 – 14371L → P in ACV92100. 1 Publication
Sequence conflicti1518 – 15181T → TA in BAC98125. 1 Publication
Sequence conflicti1577 – 15771S → P in ACV92100. 1 Publication
Sequence conflicti1769 – 17691A → V in BAC98125. 1 Publication
Sequence conflicti1773 – 17731P → S in ACV92100. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ489027 mRNA. Translation: ACV92100.1.
AC112520 Genomic DNA. No translation available.
AB054031 Genomic DNA. Translation: BAB32495.1.
AK129315 mRNA. Translation: BAC98125.1.
BC059062 mRNA. Translation: AAH59062.1.
BC094358 mRNA. Translation: AAH94358.1.
CCDSiCCDS49186.1.
RefSeqiNP_001091090.1. NM_001097621.1.
UniGeneiMm.313104.

Genome annotation databases

EnsembliENSMUST00000128402; ENSMUSP00000119482; ENSMUSG00000021294.
GeneIDi668303.
KEGGimmu:668303.
UCSCiuc007pem.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ489027 mRNA. Translation: ACV92100.1 .
AC112520 Genomic DNA. No translation available.
AB054031 Genomic DNA. Translation: BAB32495.1 .
AK129315 mRNA. Translation: BAC98125.1 .
BC059062 mRNA. Translation: AAH59062.1 .
BC094358 mRNA. Translation: AAH94358.1 .
CCDSi CCDS49186.1.
RefSeqi NP_001091090.1. NM_001097621.1.
UniGenei Mm.313104.

3D structure databases

ProteinModelPortali Q52KG5.
SMRi Q52KG5. Positions 365-721.
ModBasei Search...

Protein-protein interaction databases

IntActi Q52KG5. 2 interactions.

PTM databases

PhosphoSitei Q52KG5.

Proteomic databases

PRIDEi Q52KG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000128402 ; ENSMUSP00000119482 ; ENSMUSG00000021294 .
GeneIDi 668303.
KEGGi mmu:668303.
UCSCi uc007pem.1. mouse.

Organism-specific databases

CTDi 26153.
MGIi MGI:2447072. Kif26a.
Rougei Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00650000093360.
HOGENOMi HOG000081802.
HOVERGENi HBG108063.
InParanoidi Q52KG5.
KOi K10404.
OMAi HMSLERC.
OrthoDBi EOG7J445V.
PhylomeDBi Q52KG5.
TreeFami TF105235.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

ChiTaRSi KIF26A. mouse.
NextBioi 434531.
PROi Q52KG5.
SOURCEi Search...

Gene expression databases

Bgeei Q52KG5.
CleanExi MM_KIF26A.
Genevestigatori Q52KG5.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development."
    Zhou R., Niwa S., Homma N., Takei Y., Hirokawa N.
    Cell 139:802-813(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MICROTUBULE-BINDING, LACK OF ATPASE ACTIVITY, INTERACTION WITH GRB2.
    Strain: A/J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "All kinesin superfamily protein, KIF, genes in mouse and human."
    Miki H., Setou M., Kaneshiro K.
    Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-613.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-1881.
    Tissue: Embryonic tail.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1881.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiKI26A_MOUSE
AccessioniPrimary (citable) accession number: Q52KG5
Secondary accession number(s): C9EF47
, Q6PCY3, Q6ZPV4, Q99PT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi