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Q52KG5

- KI26A_MOUSE

UniProt

Q52KG5 - KI26A_MOUSE

Protein

Kinesin-like protein KIF26A

Gene

Kif26a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi462 – 4698ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. enteric nervous system development Source: UniProtKB
    2. negative regulation of signal transduction Source: UniProtKB
    3. regulation of cell growth by extracellular stimulus Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF26A
    Gene namesi
    Name:Kif26a
    Synonyms:Kiaa1236
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2447072. Kif26a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. kinesin complex Source: InterPro
    3. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Disruption phenotypei

    Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18811881Kinesin-like protein KIF26APRO_0000307300Add
    BLAST

    Proteomic databases

    PRIDEiQ52KG5.

    PTM databases

    PhosphoSiteiQ52KG5.

    Expressioni

    Tissue specificityi

    Expressed in several neuronal populations.1 Publication

    Developmental stagei

    Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at embryonic day 12.5 (E12.5), E14.5, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at E14.5.1 Publication

    Gene expression databases

    BgeeiQ52KG5.
    CleanExiMM_KIF26A.
    GenevestigatoriQ52KG5.

    Interactioni

    Subunit structurei

    Interacts with GRB2 (via SH2 domain).1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Grb2Q606312EBI-2480646,EBI-1688

    Protein-protein interaction databases

    IntActiQ52KG5. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ52KG5.
    SMRiQ52KG5. Positions 365-721.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini364 – 718355Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1780 – 181233Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00650000093360.
    HOGENOMiHOG000081802.
    HOVERGENiHBG108063.
    InParanoidiQ52KG5.
    KOiK10404.
    OMAiHMSLERC.
    OrthoDBiEOG7J445V.
    PhylomeDBiQ52KG5.
    TreeFamiTF105235.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q52KG5-1 [UniParc]FASTAAdd to Basket

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    MVGRGASLCA VQPAVAECGP ARETPPLEVS PRKRLPAGLD QDPCSSRPAP     50
    EGAGASAEQS HSAGGGGWCR HCHTKLVELK RQAWKLVSGP GTPLRDPCLS 100
    TLLLDKLPAS GVQPACRPDT ESRCDVCTTH LHQLTREALR LLQTPASHED 150
    PNASRGGLAA PSSRDPPGPV GLMGRQPPVG PDRRKATAWP PGPSVQVSVA 200
    PAGLGGALST VTIQAQQCLE GVWSLSRVNS FLPPTCLAEA AVAAVAVADT 250
    VRDCAPAAGP ERMSKAWGRG AACTTALVTP APGTSAGGST GPSAAASFFI 300
    RAAQKLSLAS KRKKHHPPPA PSTRGTSTYP TDFSGSLQLW PPPVPPCLLR 350
    AASKAKENPS SFGKVKVMLR IWPAQGVQRS AESTSFLKVD SRKKQVTLYD 400
    PAAGPPGCAG LRHAPTAPVP KMFAFDAIFP QDSEQAEVCS GTVADVLQSV 450
    VSGADGCIFS FGHMSLGKSY TMIGKDSSPQ SLGIVPCAIS WLFRLIDERK 500
    ERLGTRFSIR VSAVEVCGHD QSLRDLLAEV ASGSLQDTQS PGVYLREDPV 550
    CGTQLQNQNE LRAPTAEKAA FYLDAALAAR STSRAGCGEE ARRSSHMLFT 600
    LHVYQYRVEK CGQGGMSGGR SRLHLIDLGS CDAAVGRGGE ASGGPLCLSL 650
    SALGSVILAL VNGAKHVPYR DHRLTMLLRE SLATTNCRTT MIAHISDSPA 700
    HHAETLSTVQ LAARIHRLRR KKGKHASSSS GGESSCEEGR ARRPPHLRPF 750
    HPRAVVLDPD RSAPGLSGDP DYSSSSEQSC DTVIYVGPGG MALSDRELTD 800
    NEGPPDFVPI IPALSRRRPS EGPRDADHFR CSTFAELQER LECIDGSEAF 850
    PGPQGGSDGA QASPARGGRK PSLPEATPSR KAVAPTVVTS CPRGSPGHDT 900
    HRSASDPSKT GTQSEQRVDG SRPEPPASDK TSGGGGRRPL PSPAPPPPRQ 950
    PEAQGIPKEP GGEGTDSVLR TPPVGMSGQA ALPPLLSDSA YLSPSARGRH 1000
    LERGLLTTTV TLQQPVELNG EDELVFTVVE ELPLGGLAGA TRPSSLASMS 1050
    SDCSLQALAS GSRPVSIISS INDEFDAYTS QMSEGPGDPG EFPEGTAWAG 1100
    GSPASSIGSW LSDVGVCLSE SRGPTPQPPF SPNSAAGPGP PEFPTPGSSL 1150
    EESKVRSSEC GRPDNPGSAR SLHPGEAVAT TQTQPGREPW ARSPHEVASA 1200
    QTIHSSLPRK PRTTSTASRA RPSRGPYSPG GLFEDPWLLR AEDCDTRQIA 1250
    STGRAPSPTP GSPRLPETQM MLACAQRVVD GCEVASRMSR RPEAVARIPP 1300
    LRRGATTLGV TTPAASCGDA PAEAVVHSGS LKTTSGSKKS VSPKGAFFPR 1350
    PSGAGPPAPP VRKSSLEQST ALTPTQALGL TRAGAPSAFR GEEEARPSGR 1400
    SDSSVPKATS SLKARAGKMD VPYRPSGHMS LERCEGLAHG SSKVRDVVGR 1450
    PPRAVPRLGV PSASPPLGPA PACRNSPAKG VGATKPPAGG AKGRNLGPST 1500
    SRALGAPVKP LGPVAGKTAG GAVPGPRAAP RAVPGIGAKA GRGTIMGTKQ 1550
    AFRAAHSRVH ELAASGSPSR GGLSWGSTDS DSGNDSGVNL AEERQPSSPA 1600
    LPSPYSKVTA PRRPQRYSSG HGSDNSSVLS GELPPAMGRT ALFYHSGGSS 1650
    GYESMIRDSE ATGSASSAPD SMSESGTASL GARSRSLKSP KKRATGLQRR 1700
    RLIPAPLPDA AALGRKPSLP GQWVDLPPPL AGSLKEPFEI KVYEIDDVER 1750
    LQRHRLPLRE NEAKPSQDAE KGPVCISSKL RLAERRQQRL QEVQAKRDHL 1800
    CEELAETQGR LMVEPGRWLE QFEVDPELEP ESAEYLVALE QATAALEQCV 1850
    NLCKAHVMMV TCFDIGVAAT TAVPGPQEVD V 1881
    Length:1,881
    Mass (Da):196,313
    Last modified:October 23, 2007 - v2
    Checksum:i6A8B5235D7DB70D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201T → A in ACV92100. (PubMed:19914172)Curated
    Sequence conflicti152 – 1521N → D in ACV92100. (PubMed:19914172)Curated
    Sequence conflicti163 – 1631S → P in ACV92100. (PubMed:19914172)Curated
    Sequence conflicti635 – 6351V → I in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti690 – 6901T → I in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1101 – 11011G → S in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1118 – 11181L → F in AAH94358. (PubMed:15489334)Curated
    Sequence conflicti1200 – 12001A → V in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1312 – 13121T → S in ACV92100. (PubMed:19914172)Curated
    Sequence conflicti1333 – 13331T → N in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1421 – 14211V → A in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1437 – 14371L → P in ACV92100. (PubMed:19914172)Curated
    Sequence conflicti1518 – 15181T → TA in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1577 – 15771S → P in ACV92100. (PubMed:19914172)Curated
    Sequence conflicti1769 – 17691A → V in BAC98125. (PubMed:14621295)Curated
    Sequence conflicti1773 – 17731P → S in ACV92100. (PubMed:19914172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ489027 mRNA. Translation: ACV92100.1.
    AC112520 Genomic DNA. No translation available.
    AB054031 Genomic DNA. Translation: BAB32495.1.
    AK129315 mRNA. Translation: BAC98125.1.
    BC059062 mRNA. Translation: AAH59062.1.
    BC094358 mRNA. Translation: AAH94358.1.
    CCDSiCCDS49186.1.
    RefSeqiNP_001091090.1. NM_001097621.1.
    UniGeneiMm.313104.

    Genome annotation databases

    EnsembliENSMUST00000128402; ENSMUSP00000119482; ENSMUSG00000021294.
    GeneIDi668303.
    KEGGimmu:668303.
    UCSCiuc007pem.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ489027 mRNA. Translation: ACV92100.1 .
    AC112520 Genomic DNA. No translation available.
    AB054031 Genomic DNA. Translation: BAB32495.1 .
    AK129315 mRNA. Translation: BAC98125.1 .
    BC059062 mRNA. Translation: AAH59062.1 .
    BC094358 mRNA. Translation: AAH94358.1 .
    CCDSi CCDS49186.1.
    RefSeqi NP_001091090.1. NM_001097621.1.
    UniGenei Mm.313104.

    3D structure databases

    ProteinModelPortali Q52KG5.
    SMRi Q52KG5. Positions 365-721.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q52KG5. 2 interactions.

    PTM databases

    PhosphoSitei Q52KG5.

    Proteomic databases

    PRIDEi Q52KG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000128402 ; ENSMUSP00000119482 ; ENSMUSG00000021294 .
    GeneIDi 668303.
    KEGGi mmu:668303.
    UCSCi uc007pem.1. mouse.

    Organism-specific databases

    CTDi 26153.
    MGIi MGI:2447072. Kif26a.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00650000093360.
    HOGENOMi HOG000081802.
    HOVERGENi HBG108063.
    InParanoidi Q52KG5.
    KOi K10404.
    OMAi HMSLERC.
    OrthoDBi EOG7J445V.
    PhylomeDBi Q52KG5.
    TreeFami TF105235.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Miscellaneous databases

    ChiTaRSi KIF26A. mouse.
    NextBioi 434531.
    PROi Q52KG5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q52KG5.
    CleanExi MM_KIF26A.
    Genevestigatori Q52KG5.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development."
      Zhou R., Niwa S., Homma N., Takei Y., Hirokawa N.
      Cell 139:802-813(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MICROTUBULE-BINDING, LACK OF ATPASE ACTIVITY, INTERACTION WITH GRB2.
      Strain: A/J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "All kinesin superfamily protein, KIF, genes in mouse and human."
      Miki H., Setou M., Kaneshiro K.
      Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-613.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-1881.
      Tissue: Embryonic tail.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1881.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiKI26A_MOUSE
    AccessioniPrimary (citable) accession number: Q52KG5
    Secondary accession number(s): C9EF47
    , Q6PCY3, Q6ZPV4, Q99PT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3