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Protein

Kinesin-like protein KIF26A

Gene

Kif26a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity.1 Publication

Caution

In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi462 – 469ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: UniProtKB

GO - Biological processi

  • enteric nervous system development Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB
  • regulation of cell growth by extracellular stimulus Source: UniProtKB

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF26A
Gene namesi
Name:Kif26a
Synonyms:Kiaa1236
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2447072 Kif26a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073001 – 1881Kinesin-like protein KIF26AAdd BLAST1881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineBy similarity1
Modified residuei1257PhosphoserineBy similarity1
Modified residuei1654PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ52KG5
PRIDEiQ52KG5

PTM databases

iPTMnetiQ52KG5
PhosphoSitePlusiQ52KG5

Expressioni

Tissue specificityi

Expressed in several neuronal populations.1 Publication

Developmental stagei

Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at embryonic day 12.5 (E12.5), E14.5, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at E14.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000021294
CleanExiMM_KIF26A
GenevisibleiQ52KG5 MM

Interactioni

Subunit structurei

Interacts with GRB2 (via SH2 domain).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606312EBI-2480646,EBI-1688

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ52KG5, 2 interactors
STRINGi10090.ENSMUSP00000119482

Structurei

3D structure databases

ProteinModelPortaliQ52KG5
SMRiQ52KG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini364 – 718Kinesin motorPROSITE-ProRule annotationAdd BLAST355

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1780 – 1812Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00650000093360
HOGENOMiHOG000081802
HOVERGENiHBG108063
InParanoidiQ52KG5
KOiK10404
OMAiSMSESGM
OrthoDBiEOG091G0097
PhylomeDBiQ52KG5
TreeFamiTF105235

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q52KG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRGASLCA VQPAVAECGP ARETPPLEVS PRKRLPAGLD QDPCSSRPAP
60 70 80 90 100
EGAGASAEQS HSAGGGGWCR HCHTKLVELK RQAWKLVSGP GTPLRDPCLS
110 120 130 140 150
TLLLDKLPAS GVQPACRPDT ESRCDVCTTH LHQLTREALR LLQTPASHED
160 170 180 190 200
PNASRGGLAA PSSRDPPGPV GLMGRQPPVG PDRRKATAWP PGPSVQVSVA
210 220 230 240 250
PAGLGGALST VTIQAQQCLE GVWSLSRVNS FLPPTCLAEA AVAAVAVADT
260 270 280 290 300
VRDCAPAAGP ERMSKAWGRG AACTTALVTP APGTSAGGST GPSAAASFFI
310 320 330 340 350
RAAQKLSLAS KRKKHHPPPA PSTRGTSTYP TDFSGSLQLW PPPVPPCLLR
360 370 380 390 400
AASKAKENPS SFGKVKVMLR IWPAQGVQRS AESTSFLKVD SRKKQVTLYD
410 420 430 440 450
PAAGPPGCAG LRHAPTAPVP KMFAFDAIFP QDSEQAEVCS GTVADVLQSV
460 470 480 490 500
VSGADGCIFS FGHMSLGKSY TMIGKDSSPQ SLGIVPCAIS WLFRLIDERK
510 520 530 540 550
ERLGTRFSIR VSAVEVCGHD QSLRDLLAEV ASGSLQDTQS PGVYLREDPV
560 570 580 590 600
CGTQLQNQNE LRAPTAEKAA FYLDAALAAR STSRAGCGEE ARRSSHMLFT
610 620 630 640 650
LHVYQYRVEK CGQGGMSGGR SRLHLIDLGS CDAAVGRGGE ASGGPLCLSL
660 670 680 690 700
SALGSVILAL VNGAKHVPYR DHRLTMLLRE SLATTNCRTT MIAHISDSPA
710 720 730 740 750
HHAETLSTVQ LAARIHRLRR KKGKHASSSS GGESSCEEGR ARRPPHLRPF
760 770 780 790 800
HPRAVVLDPD RSAPGLSGDP DYSSSSEQSC DTVIYVGPGG MALSDRELTD
810 820 830 840 850
NEGPPDFVPI IPALSRRRPS EGPRDADHFR CSTFAELQER LECIDGSEAF
860 870 880 890 900
PGPQGGSDGA QASPARGGRK PSLPEATPSR KAVAPTVVTS CPRGSPGHDT
910 920 930 940 950
HRSASDPSKT GTQSEQRVDG SRPEPPASDK TSGGGGRRPL PSPAPPPPRQ
960 970 980 990 1000
PEAQGIPKEP GGEGTDSVLR TPPVGMSGQA ALPPLLSDSA YLSPSARGRH
1010 1020 1030 1040 1050
LERGLLTTTV TLQQPVELNG EDELVFTVVE ELPLGGLAGA TRPSSLASMS
1060 1070 1080 1090 1100
SDCSLQALAS GSRPVSIISS INDEFDAYTS QMSEGPGDPG EFPEGTAWAG
1110 1120 1130 1140 1150
GSPASSIGSW LSDVGVCLSE SRGPTPQPPF SPNSAAGPGP PEFPTPGSSL
1160 1170 1180 1190 1200
EESKVRSSEC GRPDNPGSAR SLHPGEAVAT TQTQPGREPW ARSPHEVASA
1210 1220 1230 1240 1250
QTIHSSLPRK PRTTSTASRA RPSRGPYSPG GLFEDPWLLR AEDCDTRQIA
1260 1270 1280 1290 1300
STGRAPSPTP GSPRLPETQM MLACAQRVVD GCEVASRMSR RPEAVARIPP
1310 1320 1330 1340 1350
LRRGATTLGV TTPAASCGDA PAEAVVHSGS LKTTSGSKKS VSPKGAFFPR
1360 1370 1380 1390 1400
PSGAGPPAPP VRKSSLEQST ALTPTQALGL TRAGAPSAFR GEEEARPSGR
1410 1420 1430 1440 1450
SDSSVPKATS SLKARAGKMD VPYRPSGHMS LERCEGLAHG SSKVRDVVGR
1460 1470 1480 1490 1500
PPRAVPRLGV PSASPPLGPA PACRNSPAKG VGATKPPAGG AKGRNLGPST
1510 1520 1530 1540 1550
SRALGAPVKP LGPVAGKTAG GAVPGPRAAP RAVPGIGAKA GRGTIMGTKQ
1560 1570 1580 1590 1600
AFRAAHSRVH ELAASGSPSR GGLSWGSTDS DSGNDSGVNL AEERQPSSPA
1610 1620 1630 1640 1650
LPSPYSKVTA PRRPQRYSSG HGSDNSSVLS GELPPAMGRT ALFYHSGGSS
1660 1670 1680 1690 1700
GYESMIRDSE ATGSASSAPD SMSESGTASL GARSRSLKSP KKRATGLQRR
1710 1720 1730 1740 1750
RLIPAPLPDA AALGRKPSLP GQWVDLPPPL AGSLKEPFEI KVYEIDDVER
1760 1770 1780 1790 1800
LQRHRLPLRE NEAKPSQDAE KGPVCISSKL RLAERRQQRL QEVQAKRDHL
1810 1820 1830 1840 1850
CEELAETQGR LMVEPGRWLE QFEVDPELEP ESAEYLVALE QATAALEQCV
1860 1870 1880
NLCKAHVMMV TCFDIGVAAT TAVPGPQEVD V
Length:1,881
Mass (Da):196,313
Last modified:October 23, 2007 - v2
Checksum:i6A8B5235D7DB70D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120T → A in ACV92100 (PubMed:19914172).Curated1
Sequence conflicti152N → D in ACV92100 (PubMed:19914172).Curated1
Sequence conflicti163S → P in ACV92100 (PubMed:19914172).Curated1
Sequence conflicti635V → I in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti690T → I in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1101G → S in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1118L → F in AAH94358 (PubMed:15489334).Curated1
Sequence conflicti1200A → V in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1312T → S in ACV92100 (PubMed:19914172).Curated1
Sequence conflicti1333T → N in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1421V → A in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1437L → P in ACV92100 (PubMed:19914172).Curated1
Sequence conflicti1518T → TA in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1577S → P in ACV92100 (PubMed:19914172).Curated1
Sequence conflicti1769A → V in BAC98125 (PubMed:14621295).Curated1
Sequence conflicti1773P → S in ACV92100 (PubMed:19914172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ489027 mRNA Translation: ACV92100.1
AC112520 Genomic DNA No translation available.
AB054031 Genomic DNA Translation: BAB32495.1
AK129315 mRNA Translation: BAC98125.1
BC059062 mRNA Translation: AAH59062.1
BC094358 mRNA Translation: AAH94358.1
CCDSiCCDS49186.1
RefSeqiNP_001091090.1, NM_001097621.1
UniGeneiMm.313104

Genome annotation databases

EnsembliENSMUST00000128402; ENSMUSP00000119482; ENSMUSG00000021294
GeneIDi668303
KEGGimmu:668303
UCSCiuc007pem.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKI26A_MOUSE
AccessioniPrimary (citable) accession number: Q52KG5
Secondary accession number(s): C9EF47
, Q6PCY3, Q6ZPV4, Q99PT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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