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Q52KG5 (KI26A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF26A
Gene names
Name:Kif26a
Synonyms:Kiaa1236
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1881 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. Ref.1

Subunit structure

Interacts with GRB2 (via SH2 domain). Ref.1

Subcellular location

Cytoplasmcytoskeleton Probable.

Tissue specificity

Expressed in several neuronal populations. Ref.1

Developmental stage

Strong expression is detected in substantia nigra in brain and enteric nervous system in colon at P12. In colon sections at embryonic day 12.5 (E12.5), E14.5, and P12, it is exclusively expressed in enteric nervous system (ENS). Also detected in dorsal root ganglion and spinal cord gray matter at E14.5. Ref.1

Disruption phenotype

Mice exhibit growth retardation, become emaciated, and die within 5 weeks of birth. The median and mean life span is 15 and 16 days. Macroscopic dissection reveal that mice suffered from megacolon, with dilation from the distal small intestine to the proximal colon and display enteric nerve hyperplasia. Severe occlusion are observed in the distal colon, because the colon motility is not coordinated. Defects are due to abnormal enteric nervous system (ENS) proliferation. Ref.1

Sequence similarities

Belongs to the kinesin-like protein family. KIF26 subfamily.

Contains 1 kinesin-motor domain.

Caution

In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Grb2Q606312EBI-2480646,EBI-1688

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18811881Kinesin-like protein KIF26A
PRO_0000307300

Regions

Domain361 – 654294Kinesin-motor
Nucleotide binding462 – 4698ATP Potential
Coiled coil1780 – 181233 Potential

Experimental info

Sequence conflict1201T → A in ACV92100. Ref.1
Sequence conflict1521N → D in ACV92100. Ref.1
Sequence conflict1631S → P in ACV92100. Ref.1
Sequence conflict6351V → I in BAC98125. Ref.4
Sequence conflict6901T → I in BAC98125. Ref.4
Sequence conflict11011G → S in BAC98125. Ref.4
Sequence conflict11181L → F in AAH94358. Ref.5
Sequence conflict12001A → V in BAC98125. Ref.4
Sequence conflict13121T → S in ACV92100. Ref.1
Sequence conflict13331T → N in BAC98125. Ref.4
Sequence conflict14211V → A in BAC98125. Ref.4
Sequence conflict14371L → P in ACV92100. Ref.1
Sequence conflict15181T → TA in BAC98125. Ref.4
Sequence conflict15771S → P in ACV92100. Ref.1
Sequence conflict17691A → V in BAC98125. Ref.4
Sequence conflict17731P → S in ACV92100. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q52KG5 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 6A8B5235D7DB70D2

FASTA1,881196,313
        10         20         30         40         50         60 
MVGRGASLCA VQPAVAECGP ARETPPLEVS PRKRLPAGLD QDPCSSRPAP EGAGASAEQS 

        70         80         90        100        110        120 
HSAGGGGWCR HCHTKLVELK RQAWKLVSGP GTPLRDPCLS TLLLDKLPAS GVQPACRPDT 

       130        140        150        160        170        180 
ESRCDVCTTH LHQLTREALR LLQTPASHED PNASRGGLAA PSSRDPPGPV GLMGRQPPVG 

       190        200        210        220        230        240 
PDRRKATAWP PGPSVQVSVA PAGLGGALST VTIQAQQCLE GVWSLSRVNS FLPPTCLAEA 

       250        260        270        280        290        300 
AVAAVAVADT VRDCAPAAGP ERMSKAWGRG AACTTALVTP APGTSAGGST GPSAAASFFI 

       310        320        330        340        350        360 
RAAQKLSLAS KRKKHHPPPA PSTRGTSTYP TDFSGSLQLW PPPVPPCLLR AASKAKENPS 

       370        380        390        400        410        420 
SFGKVKVMLR IWPAQGVQRS AESTSFLKVD SRKKQVTLYD PAAGPPGCAG LRHAPTAPVP 

       430        440        450        460        470        480 
KMFAFDAIFP QDSEQAEVCS GTVADVLQSV VSGADGCIFS FGHMSLGKSY TMIGKDSSPQ 

       490        500        510        520        530        540 
SLGIVPCAIS WLFRLIDERK ERLGTRFSIR VSAVEVCGHD QSLRDLLAEV ASGSLQDTQS 

       550        560        570        580        590        600 
PGVYLREDPV CGTQLQNQNE LRAPTAEKAA FYLDAALAAR STSRAGCGEE ARRSSHMLFT 

       610        620        630        640        650        660 
LHVYQYRVEK CGQGGMSGGR SRLHLIDLGS CDAAVGRGGE ASGGPLCLSL SALGSVILAL 

       670        680        690        700        710        720 
VNGAKHVPYR DHRLTMLLRE SLATTNCRTT MIAHISDSPA HHAETLSTVQ LAARIHRLRR 

       730        740        750        760        770        780 
KKGKHASSSS GGESSCEEGR ARRPPHLRPF HPRAVVLDPD RSAPGLSGDP DYSSSSEQSC 

       790        800        810        820        830        840 
DTVIYVGPGG MALSDRELTD NEGPPDFVPI IPALSRRRPS EGPRDADHFR CSTFAELQER 

       850        860        870        880        890        900 
LECIDGSEAF PGPQGGSDGA QASPARGGRK PSLPEATPSR KAVAPTVVTS CPRGSPGHDT 

       910        920        930        940        950        960 
HRSASDPSKT GTQSEQRVDG SRPEPPASDK TSGGGGRRPL PSPAPPPPRQ PEAQGIPKEP 

       970        980        990       1000       1010       1020 
GGEGTDSVLR TPPVGMSGQA ALPPLLSDSA YLSPSARGRH LERGLLTTTV TLQQPVELNG 

      1030       1040       1050       1060       1070       1080 
EDELVFTVVE ELPLGGLAGA TRPSSLASMS SDCSLQALAS GSRPVSIISS INDEFDAYTS 

      1090       1100       1110       1120       1130       1140 
QMSEGPGDPG EFPEGTAWAG GSPASSIGSW LSDVGVCLSE SRGPTPQPPF SPNSAAGPGP 

      1150       1160       1170       1180       1190       1200 
PEFPTPGSSL EESKVRSSEC GRPDNPGSAR SLHPGEAVAT TQTQPGREPW ARSPHEVASA 

      1210       1220       1230       1240       1250       1260 
QTIHSSLPRK PRTTSTASRA RPSRGPYSPG GLFEDPWLLR AEDCDTRQIA STGRAPSPTP 

      1270       1280       1290       1300       1310       1320 
GSPRLPETQM MLACAQRVVD GCEVASRMSR RPEAVARIPP LRRGATTLGV TTPAASCGDA 

      1330       1340       1350       1360       1370       1380 
PAEAVVHSGS LKTTSGSKKS VSPKGAFFPR PSGAGPPAPP VRKSSLEQST ALTPTQALGL 

      1390       1400       1410       1420       1430       1440 
TRAGAPSAFR GEEEARPSGR SDSSVPKATS SLKARAGKMD VPYRPSGHMS LERCEGLAHG 

      1450       1460       1470       1480       1490       1500 
SSKVRDVVGR PPRAVPRLGV PSASPPLGPA PACRNSPAKG VGATKPPAGG AKGRNLGPST 

      1510       1520       1530       1540       1550       1560 
SRALGAPVKP LGPVAGKTAG GAVPGPRAAP RAVPGIGAKA GRGTIMGTKQ AFRAAHSRVH 

      1570       1580       1590       1600       1610       1620 
ELAASGSPSR GGLSWGSTDS DSGNDSGVNL AEERQPSSPA LPSPYSKVTA PRRPQRYSSG 

      1630       1640       1650       1660       1670       1680 
HGSDNSSVLS GELPPAMGRT ALFYHSGGSS GYESMIRDSE ATGSASSAPD SMSESGTASL 

      1690       1700       1710       1720       1730       1740 
GARSRSLKSP KKRATGLQRR RLIPAPLPDA AALGRKPSLP GQWVDLPPPL AGSLKEPFEI 

      1750       1760       1770       1780       1790       1800 
KVYEIDDVER LQRHRLPLRE NEAKPSQDAE KGPVCISSKL RLAERRQQRL QEVQAKRDHL 

      1810       1820       1830       1840       1850       1860 
CEELAETQGR LMVEPGRWLE QFEVDPELEP ESAEYLVALE QATAALEQCV NLCKAHVMMV 

      1870       1880 
TCFDIGVAAT TAVPGPQEVD V 

« Hide

References

« Hide 'large scale' references
[1]"KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development."
Zhou R., Niwa S., Homma N., Takei Y., Hirokawa N.
Cell 139:802-813(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MICROTUBULE-BINDING, LACK OF ATPASE ACTIVITY, INTERACTION WITH GRB2.
Strain: A/J.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"All kinesin superfamily protein, KIF, genes in mouse and human."
Miki H., Setou M., Kaneshiro K.
Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-613.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-1881.
Tissue: Embryonic tail.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1881.
Strain: C57BL/6.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ489027 mRNA. Translation: ACV92100.1.
AC112520 Genomic DNA. No translation available.
AB054031 Genomic DNA. Translation: BAB32495.1.
AK129315 mRNA. Translation: BAC98125.1.
BC059062 mRNA. Translation: AAH59062.1.
BC094358 mRNA. Translation: AAH94358.1.
RefSeqNP_001091090.1. NM_001097621.1.
UniGeneMm.313104.

3D structure databases

ProteinModelPortalQ52KG5.
SMRQ52KG5. Positions 365-721.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ52KG5. 2 interactions.

PTM databases

PhosphoSiteQ52KG5.

Proteomic databases

PRIDEQ52KG5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000128402; ENSMUSP00000119482; ENSMUSG00000021294.
GeneID668303.
KEGGmmu:668303.
UCSCuc007pem.1. mouse.

Organism-specific databases

CTD26153.
MGIMGI:2447072. Kif26a.
RougeSearch...

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00650000093360.
HOGENOMHOG000081802.
HOVERGENHBG108063.
InParanoidQ52KG5.
KOK10404.
OMAHMSLERC.
OrthoDBEOG7J445V.
PhylomeDBQ52KG5.
TreeFamTF105235.

Gene expression databases

BgeeQ52KG5.
CleanExMM_KIF26A.
GenevestigatorQ52KG5.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIF26A. mouse.
NextBio434531.
PROQ52KG5.
SOURCESearch...

Entry information

Entry nameKI26A_MOUSE
AccessionPrimary (citable) accession number: Q52KG5
Secondary accession number(s): C9EF47 expand/collapse secondary AC list , Q6PCY3, Q6ZPV4, Q99PT4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot